Multiple myeloma differential diagnosis: Difference between revisions
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==Multiple Myeloma Differential Diagnosis== | ==Multiple Myeloma Differential Diagnosis== | ||
; Diseases with similar symptoms | *The table below summarizes how to differentiate multiple myeloma from other conditions that cause similar presentation:<ref>{{Cite web | last = | first = | title = Myeloma - SEER Stat Fact Sheets | url = http://seer.cancer.gov/statfacts/html/mulmy.html | publisher = | date = | accessdate = 17 February 2014 }}</ref> | ||
*[[Bone fracture]] - this includes lytic bone tumors such as: | |||
{| {{table}} | |||
| align="center" style="background:#f0f0f0;"|'''Plasma Cell Neoplasm''' | |||
| align="center" style="background:#f0f0f0;"|'''M Protein Type''' | |||
| align="center" style="background:#f0f0f0;"|'''Pathology''' | |||
| align="center" style="background:#f0f0f0;"|'''Clinical Presentation''' | |||
|- | |||
| MGUS||IgG kappa or lambda; or IgA kappa or lambda||<10% plasma cells in bone marrow||Asymptomatic, with minimal evidence of disease (aside from the presence of an M protein) [2] | |||
|- | |||
| Isolated plasmacytoma of bone||IgG kappa or lambda; or IgA kappa or gamma||Solitary lesion of bone; <10% plasma cells in marrow of uninvolved site||Asymptomatic or symptomatic | |||
|- | |||
| Extramedullary plasmacytoma||IgG kappa or lambda; or IgA kappa or gamma||Solitary lesion of soft tissue; most commonly occurs in the nasopharynx, tonsils, or paranasal sinuses [3]||Asymptomatic or symptomatic | |||
|- | |||
| Multiple myeloma||IgG kappa or lambda; or IgA kappa or gamma||Often multiple lesions of bone||Symptomatic | |||
|- | |||
|} | |||
*Diseases with similar symptoms | |||
:*[[Bone fracture]] - this includes lytic bone tumors such as: | |||
:* [[Fibrous dysplasia]] | :* [[Fibrous dysplasia]] | ||
:* [[Enchondroma]] | :* [[Enchondroma]] | ||
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:* [[Chondroblastoma]] | :* [[Chondroblastoma]] | ||
:* [[Fibroma|Chondromyxoid Fibroma]] | :* [[Fibroma|Chondromyxoid Fibroma]] | ||
* Reactive plasmacytosis | :* Reactive plasmacytosis | ||
*[[Macroglobulinemia]] | :*[[Macroglobulinemia]] | ||
*Bone metastatic tumor | :*Bone metastatic tumor | ||
* Other plasma cell disorders such as: | :* Other plasma cell disorders such as: | ||
:* [[MGUS|Monoclonal Gammopathies of Uncertain Origin]] | :* [[MGUS|Monoclonal Gammopathies of Uncertain Origin]] | ||
:* [[Waldenström's macroglobulinemia|Waldenstrom Hypergammaglobulinemia]] | :* [[Waldenström's macroglobulinemia|Waldenstrom Hypergammaglobulinemia]] | ||
Revision as of 13:14, 18 September 2015
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Multiple myeloma Microchapters |
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Multiple myeloma differential diagnosis On the Web |
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American Roentgen Ray Society Images of Multiple myeloma differential diagnosis |
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Risk calculators and risk factors for Multiple myeloma differential diagnosis |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Multiple myeloma must be differentiated from monoclonal gammopathy of undetermined significance(MGUS), isolated plasmacytoma of the bone, and extramedullary plasmacytoma.
Multiple Myeloma Differential Diagnosis
- The table below summarizes how to differentiate multiple myeloma from other conditions that cause similar presentation:[1]
| Plasma Cell Neoplasm | M Protein Type | Pathology | Clinical Presentation |
| MGUS | IgG kappa or lambda; or IgA kappa or lambda | <10% plasma cells in bone marrow | Asymptomatic, with minimal evidence of disease (aside from the presence of an M protein) [2] |
| Isolated plasmacytoma of bone | IgG kappa or lambda; or IgA kappa or gamma | Solitary lesion of bone; <10% plasma cells in marrow of uninvolved site | Asymptomatic or symptomatic |
| Extramedullary plasmacytoma | IgG kappa or lambda; or IgA kappa or gamma | Solitary lesion of soft tissue; most commonly occurs in the nasopharynx, tonsils, or paranasal sinuses [3] | Asymptomatic or symptomatic |
| Multiple myeloma | IgG kappa or lambda; or IgA kappa or gamma | Often multiple lesions of bone | Symptomatic |
- Diseases with similar symptoms
- Bone fracture - this includes lytic bone tumors such as:
- Fibrous dysplasia
- Enchondroma
- Eosinophilic granuloma
- Giant cell tumor
- Osteoblastoma
- Aneurysmal bone cyst
- Solitary bone cyst
- Hyperparathyroidism
- Infection
- Chondroblastoma
- Chondromyxoid Fibroma
- Reactive plasmacytosis
- Macroglobulinemia
- Bone metastatic tumor
- Other plasma cell disorders such as:
- Monoclonal Gammopathies of Uncertain Origin
- Waldenstrom Hypergammaglobulinemia
References
- ↑ "Myeloma - SEER Stat Fact Sheets". Retrieved 17 February 2014.