Multiple myeloma history and symptoms: Difference between revisions
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==Overview== | ==Overview== | ||
The most common symptoms of multiple myeloma include fatigue, pallor, and bone pain. However, the presenting symptoms of multiple myeloma may vary greatly due to involvement of many organ systems. The common symptoms of multiple myeloma can be remembered by the [[mnemonic]] ''CRAB'' - C = Calcium (elevated), R =Renal failure, A = Anemia, B = Bone lesions.<ref name="IMWG">International Myeloma Working Group. ''Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group.'' Br J Haematol 2003;121:749-57. PMID 12780789.</ref> | The most common symptoms of multiple myeloma include fatigue, pallor, and bone pain.<ref>Multiple myeloma. Wikipedia (2015) https://en.wikipedia.org/wiki/Multiple_myeloma#Signs_and_symptoms Accessed on September, 20th 2015</ref> However, the presenting symptoms of multiple myeloma may vary greatly due to involvement of many organ systems. The common symptoms of multiple myeloma can be remembered by the [[mnemonic]] ''CRAB'' - C = Calcium (elevated), R =Renal failure, A = Anemia, B = Bone lesions.<ref name="IMWG">International Myeloma Working Group. ''Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group.'' Br J Haematol 2003;121:749-57. PMID 12780789.</ref> | ||
==History== | ==History== | ||
Revision as of 15:32, 20 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
The most common symptoms of multiple myeloma include fatigue, pallor, and bone pain.[1] However, the presenting symptoms of multiple myeloma may vary greatly due to involvement of many organ systems. The common symptoms of multiple myeloma can be remembered by the mnemonic CRAB - C = Calcium (elevated), R =Renal failure, A = Anemia, B = Bone lesions.[2]
History
- Early multiple myeloma does not have any symptoms.
- In as many as 30-40% cases the diagnosis may be incidental and is often diagnosed on routine blood screening.
- A rise in total protein levels without a concomitant rise in albumin levels must make the physician suspicious for a possibility of multiple myeloma.
- As the tumor grows larger people may notice one or more of the symptoms.
Common Symptoms
Symptoms of multiple myeloma include:[3]
-
- Usually involves the spine and ribs, and worsens with activity.
- Persistent localized pain may indicate a pathological bone fracture
- Neurological symptoms
- Numbness
- muscle weakness
- Confusion
- Dizziness
- Headache
- visual changes
- Hypercalcemia
- Polyurea
- Polydypsia
- Constipation
- Bleeding
- Recurrent infections
References
- ↑ Multiple myeloma. Wikipedia (2015) https://en.wikipedia.org/wiki/Multiple_myeloma#Signs_and_symptoms Accessed on September, 20th 2015
- ↑ International Myeloma Working Group. Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group. Br J Haematol 2003;121:749-57. PMID 12780789.
- ↑ Multiple myeloma. Wikipedia (2015) https://en.wikipedia.org/wiki/Multiple_myeloma#Signs_and_symptoms Accessed on September, 20th 2015