DRESS syndrome laboratory findings: Difference between revisions
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==Overview== | ==Overview== | ||
==Laboratory Findings== | ==Laboratory Findings== | ||
*Laboratory findings of patients with DRESS syndrome usually differ depending on the organ involvement. | |||
*The reported incidence of organ involvement has been highly variable in described cases. | |||
The following table illustrates the incidence of organ involvement in DRESS syndrome:<ref name="pmid26271788">{{cite journal| author=Avancini J, Maragno L, Santi CG, Criado PR| title=Drug reaction with eosinophilia and systemic symptoms/drug-induced hypersensitivity syndrome: clinical features of 27 patients. | journal=Clin Exp Dermatol | year= 2015 | volume= | issue= | pages= | pmid=26271788 | doi=10.1111/ced.12682 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26271788 }} </ref><ref name="pmid20713773">{{cite journal| author=Chen YC, Chiu HC, Chu CY| title=Drug reaction with eosinophilia and systemic symptoms: a retrospective study of 60 cases. | journal=Arch Dermatol | year= 2010 | volume= 146 | issue= 12 | pages= 1373-9 | pmid=20713773 | doi=10.1001/archdermatol.2010.198 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20713773 }} </ref><ref name="pmid21592453">{{cite journal| author=Cacoub P, Musette P, Descamps V, Meyer O, Speirs C, Finzi L et al.| title=The DRESS syndrome: a literature review. | journal=Am J Med | year= 2011 | volume= 124 | issue= 7 | pages= 588-97 | pmid=21592453 | doi=10.1016/j.amjmed.2011.01.017 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21592453 }} </ref> | |||
{| class="wikitable" | {| class="wikitable" | ||
!colspan=2|Incidence of organ involvement in DRESS syndrome | !colspan=2|Incidence of organ involvement in DRESS syndrome | ||
|- | |- | ||
! Organ !! Percent of patients with involvement | ! Organ !! Percent of patients with involvement | ||
|- | |- | ||
| Liver || | | Liver || 60% - 90% | ||
|- | |- | ||
| Kidney || 40% | | Kidney || 40% - 50% | ||
|- | |- | ||
| Pulmonary || | | Pulmonary || 30% - 40% | ||
|- | |- | ||
| Cardiac/muscular || 15% | | Cardiac/muscular || 15% -20% | ||
|- | |- | ||
| Pancreas || 5% | | Pancreas || 5% - 10% | ||
|- | |||
Lung || 5% - 10% | |||
|} | |} | ||
The following table illustrates the incidence of common lab abnormalities associated with DRESS syndrome:<ref name="pmid26271788">{{cite journal| author=Avancini J, Maragno L, Santi CG, Criado PR| title=Drug reaction with eosinophilia and systemic symptoms/drug-induced hypersensitivity syndrome: clinical features of 27 patients. | journal=Clin Exp Dermatol | year= 2015 | volume= | issue= | pages= | pmid=26271788 | doi=10.1111/ced.12682 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26271788 }} </ref><ref name="pmid20713773">{{cite journal| author=Chen YC, Chiu HC, Chu CY| title=Drug reaction with eosinophilia and systemic symptoms: a retrospective study of 60 cases. | journal=Arch Dermatol | year= 2010 | volume= 146 | issue= 12 | pages= 1373-9 | pmid=20713773 | doi=10.1001/archdermatol.2010.198 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20713773 }} </ref><ref name="pmid21592453">{{cite journal| author=Cacoub P, Musette P, Descamps V, Meyer O, Speirs C, Finzi L et al.| title=The DRESS syndrome: a literature review. | journal=Am J Med | year= 2011 | volume= 124 | issue= 7 | pages= 588-97 | pmid=21592453 | doi=10.1016/j.amjmed.2011.01.017 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21592453 }} </ref> | |||
{| class="wikitable" | {| class="wikitable" | ||
!colspan=2|Incidence of hematologic abnormalities in DRESS syndrome | !colspan=2|Incidence of hematologic abnormalities in DRESS syndrome | ||
|- | |- | ||
! Abnormality!! Percent of patients with abnormality | ! Abnormality!! Percent of patients with abnormality | ||
|- | |- | ||
| Atypical | | Atypical lymphocytes || 60% - 70% | ||
|- | |- | ||
| Eosinophilia || | | Eosinophilia || 50% - 70% | ||
|- | |- | ||
| Lymphocytopenia || | | Lymphocytopenia || 40% - 50% | ||
|- | |- | ||
| Thrombocytopenia || 25% | | Thrombocytopenia || 25% - 50% | ||
|- | |- | ||
| Lymphocytosis || 25% | | Lymphocytosis || 25% - 50% | ||
|} | |} | ||
==References== | ==References== | ||
Revision as of 14:32, 21 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Laboratory Findings
- Laboratory findings of patients with DRESS syndrome usually differ depending on the organ involvement.
- The reported incidence of organ involvement has been highly variable in described cases.
The following table illustrates the incidence of organ involvement in DRESS syndrome:[1][2][3]
Lung || 5% - 10%| Incidence of organ involvement in DRESS syndrome | |
|---|---|
| Organ | Percent of patients with involvement |
| Liver | 60% - 90% |
| Kidney | 40% - 50% |
| Pulmonary | 30% - 40% |
| Cardiac/muscular | 15% -20% |
| Pancreas | 5% - 10% |
The following table illustrates the incidence of common lab abnormalities associated with DRESS syndrome:[1][2][3]
| Incidence of hematologic abnormalities in DRESS syndrome | |
|---|---|
| Abnormality | Percent of patients with abnormality |
| Atypical lymphocytes | 60% - 70% |
| Eosinophilia | 50% - 70% |
| Lymphocytopenia | 40% - 50% |
| Thrombocytopenia | 25% - 50% |
| Lymphocytosis | 25% - 50% |
References
- ↑ 1.0 1.1 Avancini J, Maragno L, Santi CG, Criado PR (2015). "Drug reaction with eosinophilia and systemic symptoms/drug-induced hypersensitivity syndrome: clinical features of 27 patients". Clin Exp Dermatol. doi:10.1111/ced.12682. PMID 26271788.
- ↑ 2.0 2.1 Chen YC, Chiu HC, Chu CY (2010). "Drug reaction with eosinophilia and systemic symptoms: a retrospective study of 60 cases". Arch Dermatol. 146 (12): 1373–9. doi:10.1001/archdermatol.2010.198. PMID 20713773.
- ↑ 3.0 3.1 Cacoub P, Musette P, Descamps V, Meyer O, Speirs C, Finzi L; et al. (2011). "The DRESS syndrome: a literature review". Am J Med. 124 (7): 588–97. doi:10.1016/j.amjmed.2011.01.017. PMID 21592453.