DRESS syndrome laboratory findings: Difference between revisions
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==Overview== | ==Overview== | ||
Laboratory findings of patients with DRESS syndrome usually differ depending on the organ involvement. Common Lab findings include [[anemia]], [[eosinophilia]], [[atypical lymphocytosis]], [[monocytosis]], and [[thrombocytopenia]] | |||
==Laboratory Findings== | ==Laboratory Findings== | ||
The following laboratory tests are usually performed to identify DRESS syndrome and associated complications: | The following laboratory tests are usually performed to identify DRESS syndrome and associated complications: | ||
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! Abnormality!! Percent of patients with abnormality | ! Abnormality!! Percent of patients with abnormality | ||
|- | |- | ||
| Atypical lymphocytes || 60% - 70% | | [[Atypical lymphocytes]] || 60% - 70% | ||
|- | |- | ||
| Eosinophilia || 50% - 70% | | [[Eosinophilia]] || 50% - 70% | ||
|- | |- | ||
| | | [[Anemia]] || 50% - 60% | ||
|- | |- | ||
| | | [[Monocytosis]] ||40% - 50% | ||
|- | |- | ||
| Lymphocytosis || 25% - 50% | | [[Lymphocytopenia]] || 40% - 50% | ||
|- | |||
| [[Thrombocytopenia]] || 25% - 50% | |||
|- | |||
| [[Lymphocytosis]] || 25% - 50% | |||
|} | |} | ||
Revision as of 14:53, 21 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Laboratory findings of patients with DRESS syndrome usually differ depending on the organ involvement. Common Lab findings include anemia, eosinophilia, atypical lymphocytosis, monocytosis, and thrombocytopenia
Laboratory Findings
The following laboratory tests are usually performed to identify DRESS syndrome and associated complications:
- Complete blood count
- Liver function tests (ALT, AST, GGT, ALP, bilirubin)
- Serum creatinine
- TSH (may be considered at diagnosis and after 2-3 months due to high incidence of thyroiditis)
- Urinalysis
Laboratory findings of patients with DRESS syndrome usually differ depending on the organ involvement. The reported incidence of organ involvement has been highly variable in described cases. The following table illustrates the incidence of organ involvement in DRESS syndrome:[1][2][3]
| Incidence of organ involvement in DRESS syndrome | |
|---|---|
| Organ | Percent of patients with involvement |
| Liver | 60% - 90% |
| Kidney | 40% - 50% |
| Pulmonary | 30% - 40% |
| Cardiac/muscular | 15% -20% |
| Pancreas | 5% - 10% |
| Lung | 5% - 10% |
The following table illustrates the incidence of common lab abnormalities associated with DRESS syndrome:[1][2][3]
| Incidence of hematologic abnormalities in DRESS syndrome | |
|---|---|
| Abnormality | Percent of patients with abnormality |
| Atypical lymphocytes | 60% - 70% |
| Eosinophilia | 50% - 70% |
| Anemia | 50% - 60% |
| Monocytosis | 40% - 50% |
| Lymphocytopenia | 40% - 50% |
| Thrombocytopenia | 25% - 50% |
| Lymphocytosis | 25% - 50% |
References
- ↑ 1.0 1.1 Avancini J, Maragno L, Santi CG, Criado PR (2015). "Drug reaction with eosinophilia and systemic symptoms/drug-induced hypersensitivity syndrome: clinical features of 27 patients". Clin Exp Dermatol. doi:10.1111/ced.12682. PMID 26271788.
- ↑ 2.0 2.1 Chen YC, Chiu HC, Chu CY (2010). "Drug reaction with eosinophilia and systemic symptoms: a retrospective study of 60 cases". Arch Dermatol. 146 (12): 1373–9. doi:10.1001/archdermatol.2010.198. PMID 20713773.
- ↑ 3.0 3.1 Cacoub P, Musette P, Descamps V, Meyer O, Speirs C, Finzi L; et al. (2011). "The DRESS syndrome: a literature review". Am J Med. 124 (7): 588–97. doi:10.1016/j.amjmed.2011.01.017. PMID 21592453.