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| style="padding: 5px 5px; background: #DCDCDC; text-align: center;" | '''Precursor T-cell neoplasm'''  
| style="padding: 5px 5px; background: #DCDCDC; text-align: center;" | '''Precursor T-cell neoplasm'''  
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|-
| style="padding: 5px 5px; background: #F5F5F5;" | Precursor B-acute lymphoblastic leukemia / [[lymphoblastic lymphoma]] (LBL)
| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | Precursor B-acute lymphoblastic leukemia / [[lymphoblastic lymphoma]] (LBL)
| style="padding: 5px 5px; background: #F5F5F5;" | Precursor T-acute lymphoblastic leukemia / [[lymphoblastic lymphoma]] (LBL)
| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | Precursor T-acute lymphoblastic leukemia / [[lymphoblastic lymphoma]] (LBL)
|-
|-
| style="padding: 5px 5px; background: #DCDCDC; text-align: center; font-weight: bold;" | Peripheral B-cell neoplasms
| style="padding: 5px 5px; background: #DCDCDC; text-align: center; font-weight: bold;" | Peripheral B-cell neoplasms
| style="padding: 5px 5px; background: #DCDCDC; text-align: center; font-weight: bold;" | Peripheral T-cell and NK-cell neoplasms
| style="padding: 5px 5px; background: #DCDCDC; text-align: center; font-weight: bold;" | Peripheral T-cell and NK-cell neoplasms
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|-
| style="padding: 5px 5px; background: #F5F5F5;" | B-cell CLL / [[small lymphocytic lymphoma]]
| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | B-cell CLL / [[small lymphocytic lymphoma]]
| style="padding: 5px 5px; background: #F5F5F5;" | T-cell CLL / prolymphocytic leukemia
| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | T-cell CLL / prolymphocytic leukemia
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|-
| style="padding: 5px 5px; background: #F5F5F5;" | B-cell pro lymphocytic leukemia
| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | B-cell pro lymphocytic leukemia
| style="padding: 5px 5px; background: #F5F5F5;" |[[T-cell granular lymphocytic leukemia]]
| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | [[T-cell granular lymphocytic leukemia]]
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|-
| style="padding: 5px 5px; background: #F5F5F5;" | [[Lymphoplasmacytic lymphoma]] / immunocytoma
| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | [[Lymphoplasmacytic lymphoma]] / immunocytoma
| style="padding: 5px 5px; background: #F5F5F5;" | [[Mycosis fungoides]] / [[Sézary syndrome]]
| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | [[Mycosis fungoides]] / [[Sézary syndrome]]
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|-
| style="padding: 5px 5px; background: #F5F5F5;" | [[Mantle cell lymphoma]]
| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | [[Mantle cell lymphoma]]
| style="padding: 5px 5px; background: #F5F5F5;" | [[Peripheral T-cell lymphoma]], not otherwise characterized
| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | [[Peripheral T-cell lymphoma]], not otherwise characterized
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|-
| style="padding: 5px 5px; background: #F5F5F5;" | [[Follicular lymphoma]]
| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | [[Follicular lymphoma]]
| style="padding: 5px 5px; background: #F5F5F5;" | Hepatosplenic gamma / delta T-cell lymphoma
| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | Hepatosplenic gamma / delta T-cell lymphoma
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|-
| style="padding: 5px 5px; background: #F5F5F5;" | Extra nodal marginal zone B-cell lymphoma of mucosa-associated lymphatic tissue (MALT) type
| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | Extra nodal marginal zone B-cell lymphoma of mucosa-associated lymphatic tissue (MALT) type
| style="padding: 5px 5px; background: #F5F5F5;" | [[Subcutaneous panniculitis-like T-cell lymphoma]]
| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | [[Subcutaneous panniculitis-like T-cell lymphoma]]
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|-
| style="padding: 5px 5px; background: #F5F5F5;" | [[Nodal marginal zone B-cell lymphoma]] (± mono cytoid B-cells)
| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | [[Nodal marginal zone B-cell lymphoma]] (± mono cytoid B-cells)
| style="padding: 5px 5px; background: #F5F5F5;" | Angio immunoblastic T-cell lymphoma
| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | Angio immunoblastic T-cell lymphoma
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| style="padding: 5px 5px; background: #F5F5F5;" | [[Splenic marginal zone lymphoma]] (± villous lymphocytes)
| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | [[Splenic marginal zone lymphoma]] (± villous lymphocytes)
| style="padding: 5px 5px; background: #F5F5F5;" | Extranodal T-/NK-cell lymphoma, nasal type
| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | Extranodal T-/NK-cell lymphoma, nasal type
|-
|-
| style="padding: 5px 5px; background: #F5F5F5;" | [[Hairy cell leukemia]]
| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | [[Hairy cell leukemia]]
| style="padding: 5px 5px; background: #F5F5F5;" | [[Enteropathy-type intestinal T-cell lymphoma]]
| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | [[Enteropathy-type intestinal T-cell lymphoma]]
|-
|-
| style="padding: 5px 5px; background: #F5F5F5;" | Plasmacytoma / [[plasma cell myeloma]]
| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | Plasmacytoma / [[plasma cell myeloma]]
| style="padding: 5px 5px; background: #F5F5F5;" | Adult T-cell lymphoma / leukemia (human T-lymphotrophic virus [HTLV] 1+)
| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | Adult T-cell lymphoma / leukemia (human T-lymphotrophic virus [HTLV] 1+)
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| style="padding: 5px 5px; background: #F5F5F5;" | [[Diffuse large B-cell lymphoma]]
| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | [[Diffuse large B-cell lymphoma]]
| style="padding: 5px 5px; background: #F5F5F5;" | [[Anaplastic large cell lymphoma]], primary systemic type
| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | [[Anaplastic large cell lymphoma]], primary systemic type
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| style="padding: 5px 5px; background: #F5F5F5;" | [[Burkitt lymphoma]]
| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | [[Burkitt lymphoma]]
| style="padding: 5px 5px; background: #F5F5F5;" | Anaplastic large cell lymphoma, primary cutaneous type
| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | Anaplastic large cell lymphoma, primary cutaneous type
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| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" |
| style="padding: 5px 5px; background: #F5F5F5;" | [[Aggressive NK-cell leukemia]]
| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | [[Aggressive NK-cell leukemia]]
|}
|}


Revision as of 15:52, 22 September 2015

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]

Overview

Non-Hodgkin lymphoma may be classified according to updated REAL/WHO classification into 2 groups: B-cell neoplasms and T-cell and putative NK-cell neoplasms. Non-Hodgkin lymphoma may be classified based on rate of growth into 2 Groups:low-grade or indolent lymphoma and high-grade or aggressive lymphoma.

Classification of Non-Hodgkin lymphoma

A. Updated REAL/WHO classification

  • Non-Hodgkin lymphoma may be classified according to updated REAL/WHO classification into 2 groups:[1]
  • B-cell neoplasms
  • T-cell and putative NK-cell neoplasms
Updated REAL/WHO classification of Non-Hodgkin lymphoma
B-cell neoplasms T-cell and putative NK-cell neoplasms
Precursor B-cell neoplasm Precursor T-cell neoplasm
Precursor B-acute lymphoblastic leukemia / lymphoblastic lymphoma (LBL) Precursor T-acute lymphoblastic leukemia / lymphoblastic lymphoma (LBL)
Peripheral B-cell neoplasms Peripheral T-cell and NK-cell neoplasms
B-cell CLL / small lymphocytic lymphoma T-cell CLL / prolymphocytic leukemia
B-cell pro lymphocytic leukemia T-cell granular lymphocytic leukemia
Lymphoplasmacytic lymphoma / immunocytoma Mycosis fungoides / Sézary syndrome
Mantle cell lymphoma Peripheral T-cell lymphoma, not otherwise characterized
Follicular lymphoma Hepatosplenic gamma / delta T-cell lymphoma
Extra nodal marginal zone B-cell lymphoma of mucosa-associated lymphatic tissue (MALT) type Subcutaneous panniculitis-like T-cell lymphoma
Nodal marginal zone B-cell lymphoma (± mono cytoid B-cells) Angio immunoblastic T-cell lymphoma
Splenic marginal zone lymphoma (± villous lymphocytes) Extranodal T-/NK-cell lymphoma, nasal type
Hairy cell leukemia Enteropathy-type intestinal T-cell lymphoma
Plasmacytoma / plasma cell myeloma Adult T-cell lymphoma / leukemia (human T-lymphotrophic virus [HTLV] 1+)
Diffuse large B-cell lymphoma Anaplastic large cell lymphoma, primary systemic type
Burkitt lymphoma Anaplastic large cell lymphoma, primary cutaneous type
Aggressive NK-cell leukemia

B. Classification based on rate of growth

  • Non-Hodgkin lymphoma may be classified based on rate of growth into 2 Groups:[2]
  • Low-grade or Indolent lymphoma
  • High-grade or Aggressive lymphoma
Non-Hodgkin lymphoma classification
Grade Description
Low-grade or Indolent lymphoma Tend to grow very slowly, tend to widespread by the time they are diagnosed, often involving the bone marrow and spleen.
Often treated only when symptoms appear.
Can shrink or seem to disappear with treatment, but they tend to come back.
Can change into more aggressive lymphomas.
Have a fairly good prognosis.
High-grade or Aggressive lymphoma Grow quickly and tend to spread to lymph nodes or other organs throughout the body.
Cause symptoms and need treatment right away.
Can frequently be successfully treated with intensive chemotherapy treatment.

References

  1. ↑ National Cancer Institute. Physician Data Query Database 2015.http://www.cancer.gov/publications/pdq
  2. ↑ "Canadian Cancer Society Grades of non-Hodgkin lymphoma".

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