Carcinoma of the penis pathophysiology: Difference between revisions
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'''Editor(s)-in-Chief:''' [[C. Michael Gibson, M.S., M.D.]] [mailto:charlesmichaelgibson@gmail.com] Phone:617-632-7753; Joel Gelman, M.D. [mailto:jgelman@uci.edu], ''Director of the Center for Reconstructive Urology and Associate Clinical Professor in the Department of Urology at the University of California,Irvine'' | '''Editor(s)-in-Chief:''' [[C. Michael Gibson, M.S., M.D.]] [mailto:charlesmichaelgibson@gmail.com] Phone:617-632-7753; Joel Gelman, M.D. [mailto:jgelman@uci.edu], ''Director of the Center for Reconstructive Urology and Associate Clinical Professor in the Department of Urology at the University of California,Irvine'' | ||
==Overview== | ==Overview== | ||
==Pathogenesis== | |||
* Penile cancer arises from precursor lesions, which generally progress from low-grade to high-grade lesions. | |||
* For HPV related penile cancers this sequence is as follows:<ref name="pmid18607597">{{cite journal| author=Bleeker MC, Heideman DA, Snijders PJ, Horenblas S, Dillner J, Meijer CJ| title=Penile cancer: epidemiology, pathogenesis and prevention. | journal=World J Urol | year= 2009 | volume= 27 | issue= 2 | pages= 141-50 | pmid=18607597 | doi=10.1007/s00345-008-0302-z | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18607597 }} </ref> | |||
:* A. [[Squamous]] [[hyperplasia]] | |||
:* B. Low-grade penile intraepithelial neoplasia (PIN) | |||
:* C. High-grade PIN (carcinoma [[in situ]]—[[Bowen's disease]], [[Erythroplasia of Queyrat]] and [[bowenoid papulosis]] (BP)) | |||
:* D. Invasive carcinoma of the penis | |||
==Gross Pathology== | ==Gross Pathology== | ||
==Microscopic Pathology == | |||
==References== | ==References== |
Revision as of 18:34, 22 September 2015
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Editor(s)-in-Chief: C. Michael Gibson, M.S., M.D. [1] Phone:617-632-7753; Joel Gelman, M.D. [2], Director of the Center for Reconstructive Urology and Associate Clinical Professor in the Department of Urology at the University of California,Irvine
Overview
Pathogenesis
- Penile cancer arises from precursor lesions, which generally progress from low-grade to high-grade lesions.
- For HPV related penile cancers this sequence is as follows:[1]
- A. Squamous hyperplasia
- B. Low-grade penile intraepithelial neoplasia (PIN)
- C. High-grade PIN (carcinoma in situ—Bowen's disease, Erythroplasia of Queyrat and bowenoid papulosis (BP))
- D. Invasive carcinoma of the penis
Gross Pathology
Microscopic Pathology
References
- ↑ Bleeker MC, Heideman DA, Snijders PJ, Horenblas S, Dillner J, Meijer CJ (2009). "Penile cancer: epidemiology, pathogenesis and prevention". World J Urol. 27 (2): 141–50. doi:10.1007/s00345-008-0302-z. PMID 18607597.