Carcinoid syndrome causes: Difference between revisions

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Revision as of 19:03, 23 September 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2]

Occasionally, gastrointestinal carcinoids occur in association with inherited syndromes, such as MEN1 and NF1.

Most carcinoids associated with MEN1 appear to be of foregut origin.
NF1 is an autosomal dominant genetic disorder caused by alteration of the NF1 gene at chromosome 17q11.

In sporadic gastrointestinal carcinoids, numerous chromosomal imbalances have been found by comparative genome hybridization analysis. Gains involving chromosomes 5, 14, 17 (especially 17q), and 19 and losses involving chromosomes 11 (especially 11q) and 18 appear to be the most common.

@@ Line 5: / Line 5: @@
 ==Causes==
-*Occasionally, gastro intestinal carcinoids occur in association with inherited syndromes, such as MEN1 and NF1.<ref>{{Cite web | title =Molecular genetics
+*Occasionally, gastrointestinal carcinoids occur in association with inherited syndromes, such as MEN1 and NF1.
- | url =http://www.cancer.gov/types/gastro intestinal-carcinoid-tumors/hp/gastro intestinal-carcinoid-treatment-pdq#section/_21 }}</ref>
+:*Most carcinoids associated with MEN1 appear to be of foregut origin.
-*In sporadic gastro intestinal carcinoids, numerous chromosomal imbalances have been found by comparative genome hybridization analysis. Gains involving chromosomes 5, 14, 17 (especially 17q), and 19 and losses involving chromosomes 11 (especially 11q) and 18 appear to be the most common.
+:*NF1 is an autosomal dominant genetic disorder caused by alteration of the NF1 gene at chromosome 17q11.
+*In sporadic gastrointestinal carcinoids, numerous chromosomal imbalances have been found by comparative genome hybridization analysis. Gains involving chromosomes 5, 14, 17 (especially 17q), and 19 and losses involving chromosomes 11 (especially 11q) and 18 appear to be the most common.
 ==References==