Glioma natural history, complications and prognosis: Difference between revisions
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==Prognosis== | ==Prognosis== | ||
The prognosis for glioma varies with the grade of tumor: WHO grade 1 and WHO grade 4 have the most favorable and worst prognosis, respectively. The 1-year and 2-year survival rate of patients with [[malignant|malignant glioma]] is approximately 50% and 25%, respectively. | *The prognosis for glioma varies with the grade of tumor: WHO grade 1 and WHO grade 4 have the most favorable and worst prognosis, respectively. | ||
*The 1-year and 2-year survival rate of patients with [[malignant|malignant glioma]] is approximately 50% and 25%, respectively. | |||
The prognosis for glioma may depend on other factors which include:<ref name=eee>Prognostic factors of glioma. National Cancer Institute. http://www.cancer.gov/types/brain/patient/adult-brain-treatment-pdq</ref> | *The prognosis for glioma may depend on other factors which include:<ref name=eee>Prognostic factors of glioma. National Cancer Institute. http://www.cancer.gov/types/brain/patient/adult-brain-treatment-pdq</ref> | ||
*Tumor is in the [[brain]] or [[spinal cord]] | :*Tumor is in the [[brain]] or [[spinal cord]] | ||
*Whether the tumor can be removed by [[surgery]] | :*Whether the tumor can be removed by [[surgery]] | ||
*Whether the cancer has just been diagnosed or has recurred | :*Whether the cancer has just been diagnosed or has recurred | ||
*DNA [[methylation]] of the O6-methylguanine-DNA methyltransferase (''MGMT'') gene promoter | :*DNA [[methylation]] of the O6-methylguanine-DNA methyltransferase (''MGMT'') gene promoter | ||
*Mutation of [[isocitrate dehydrogenase]]: IDH1 or [[IDH2]] genes | :*Mutation of [[isocitrate dehydrogenase]]: IDH1 or [[IDH2]] genes | ||
*Codeletion of [[chromosomes]] 1p and 19q | :*Codeletion of [[chromosomes]] 1p and 19q | ||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
Revision as of 18:59, 23 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Common complications of glioma include brain herniation, coma, metastasis, and recurrence. The prognosis for glioma varies with the grade of tumor. The 1-year and 2-year survival rate of patients with malignant glioma is approximately 50% and 25%, respectively.
Complications
Common complications of glioma include:
- Brain herniation
- Coma
- Metastasis
- Recurrence
- Side effects of chemotherapy
- Side effects of radiation therapy
Prognosis
- The prognosis for glioma varies with the grade of tumor: WHO grade 1 and WHO grade 4 have the most favorable and worst prognosis, respectively.
- The 1-year and 2-year survival rate of patients with malignant glioma is approximately 50% and 25%, respectively.
- The prognosis for glioma may depend on other factors which include:[1]
- Tumor is in the brain or spinal cord
- Whether the tumor can be removed by surgery
- Whether the cancer has just been diagnosed or has recurred
- DNA methylation of the O6-methylguanine-DNA methyltransferase (MGMT) gene promoter
- Mutation of isocitrate dehydrogenase: IDH1 or IDH2 genes
- Codeletion of chromosomes 1p and 19q
References
- ↑ Prognostic factors of glioma. National Cancer Institute. http://www.cancer.gov/types/brain/patient/adult-brain-treatment-pdq