Tumor lysis syndrome laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2]

Overview

Laboratory findings consistent with the diagnosis of tumor lysis syndrome include high serum uric acid, potassium, phosphorus, and low calcium.

Laboratory Findings

Laboratory findings consistent with the diagnosis of tumor lysis syndrome include:

• Blood:

• Hyperuricemia ≥ 476 μmol/l
• Hyperphosphatemia ≥ 2·1 mmol/l (children), x ≥1·45 mmol/l (adults)
• Hyperkalemia ≥ 6·0 mmol/l
• Hypocalcemia ≤ 1·75 mmol/l
• Creatinine ≥1.5 x ULN

• Urinalysis:

• Low urine output
• Uric acid crystals or amorphous urates
• High uric acid-creatinine ratio > 1.0