Osteosarcoma risk factors

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Risk Factors

• Age and height: Data suggest that the risk of osteosarcoma is highest during the teenage "growth spurt." Children with osteosarcoma are usually tall for their age.
• Radiation to bones: People who were treated with radiation for another cancer have a higher risk of later developing post-radiation (after radiation) osteosarcoma.
• Drugs: Past treatment with anticancer drugs called alkylating antineoplastic agents.
• Certain bone diseases: Some bone diseases such as Paget disease of bone and multiple hereditary osteochondromas may be risk factors of osteosarcoma.
• Inherited cancer syndromes: Genetic diseases that Predispose to osteosarcoma are:

• Bloom syndrome
• Diamond-Blackfan anemia
• Familial adenomatous polyposis
• Li-Fraumeni syndrome
• Paget disease
• Hereditary retinoblastoma
• Rothmund-Thomson syndrome
• Werner syndrome
• RAPADILINO syndrome