Glioma natural history, complications and prognosis: Difference between revisions
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*The prognosis for glioma varies with the grade of tumor: WHO grade 1 and WHO grade 4 have the most favorable and worst prognosis, respectively. | *The prognosis for glioma varies with the grade of tumor: WHO grade 1 and WHO grade 4 have the most favorable and worst prognosis, respectively. | ||
*The 1-year and 2-year survival rate of patients with [[malignant|malignant glioma]] is approximately 50% and 25%, respectively. | *The 1-year and 2-year survival rate of patients with [[malignant|malignant glioma]] is approximately 50% and 25%, respectively. | ||
*Post-operative [[radiation therapy]] is often used as an adjunct to [[surgery]] in the treatment of high-grade gliomas as it has shown to double the median survival for high-grade gliomas to 37 weeks | *Post-operative [[radiation therapy]] is often used as an adjunct to [[surgery]] in the treatment of high-grade gliomas as it has shown to double the median survival for high-grade gliomas to 37 weeks (versus 17 weeks with surgery alone). | ||
*The prognosis for glioma may depend on other factors which include:<ref name=eee>Prognostic factors of glioma. National Cancer Institute. http://www.cancer.gov/types/brain/patient/adult-brain-treatment-pdq</ref> | *The prognosis for glioma may depend on other factors which include:<ref name=eee>Prognostic factors of glioma. National Cancer Institute. http://www.cancer.gov/types/brain/patient/adult-brain-treatment-pdq</ref> | ||
:*Location of the tumor ([[brain]] or [[spinal cord]]) | :*Location of the tumor ([[brain]] or [[spinal cord]]) | ||
Revision as of 17:46, 28 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Common complications of glioma include brain herniation, hydrocephalus, coma, metastasis, and recurrence. The prognosis for glioma varies with the grade of tumor. The 1-year and 2-year survival rate of patients with malignant glioma is approximately 50% and 25%, respectively.[1]
Complications
Common complications of glioma include:
- Brain herniation
- Hydrocephalus
- Coma
- Metastasis
- Recurrence
- Side effects of chemotherapy
- Side effects of radiation therapy
Prognosis
- The prognosis for glioma varies with the grade of tumor: WHO grade 1 and WHO grade 4 have the most favorable and worst prognosis, respectively.
- The 1-year and 2-year survival rate of patients with malignant glioma is approximately 50% and 25%, respectively.
- Post-operative radiation therapy is often used as an adjunct to surgery in the treatment of high-grade gliomas as it has shown to double the median survival for high-grade gliomas to 37 weeks (versus 17 weeks with surgery alone).
- The prognosis for glioma may depend on other factors which include:[1]
- Location of the tumor (brain or spinal cord)
- Resectability
- Primary diagnosis vs. recurrence
- Specific mutations:
- DNA methylation of the O6-methylguanine-DNA methyltransferase (MGMT) gene promoter
- Mutation of isocitrate dehydrogenase: IDH1 or IDH2 genes
- Codeletion of chromosomes 1p and 19q
References
- ↑ 1.0 1.1 Prognostic factors of glioma. National Cancer Institute. http://www.cancer.gov/types/brain/patient/adult-brain-treatment-pdq