Burkitt's lymphoma medical therapy: Difference between revisions
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The predominant therapy for Burkitt's lymphoma is chemotherapy. Adjunctive [[immunotherapy]] and [[stem cell transplantation]] may be required. | The predominant therapy for Burkitt's lymphoma is chemotherapy. Adjunctive [[immunotherapy]] and [[stem cell transplantation]] may be required. | ||
==Medical Therapy== | ==Medical Therapy== | ||
The predominant therapy for Burkitt's lymphoma is chemotherapy. Adjunctive [[immunotherapy]] and [[stem cell transplantation]] may be required.<ref Name= Cancer.ca>Burkitt lymphoma | The predominant therapy for Burkitt's lymphoma is chemotherapy. Adjunctive [[immunotherapy]] and [[stem cell transplantation]] may be required.<ref Name= Cancer.ca>Burkitt lymphoma. Canadian Cancer Society. http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/burkitt-lymphoma/?region=on Accessed on September 28, 2015</ref> | ||
. Canadian Cancer Society. http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/burkitt-lymphoma/?region=on Accessed on September 28, 2015</ref> | |||
===Chemotherapy=== | ===Chemotherapy=== | ||
* Drug Regimen: (CODOX-M) [[Cyclophosphamide]], {{and}} [[Vincristine]], {{and}} [[Doxorubicin]], {{and}} [[Methotrexate]] | * Drug Regimen: (CODOX-M) [[Cyclophosphamide]], {{and}} [[Vincristine]], {{and}} [[Doxorubicin]], {{and}} [[Methotrexate]] | ||
* Drug Regimen: (IVAC) [[Ifosfamide]] {{plus}} [[Mesna]], {{and}} [[Etoposide]], {{and}} [[Cytarabine]] | * Drug Regimen: (IVAC) [[Ifosfamide]] {{plus}} [[Mesna]], {{and}} [[Etoposide]], {{and}} [[Cytarabine]] | ||
* Drug Regimen: (Hyper-CVAD) [[Cyclophosphamide]], {{and}} [[Vincristine]], {{and}} [[Doxorubicin]], {{and}} [[Dexamethasone]], {{and}} [[Methotrexate]], {{and}} [[Cytarabine]] | * Drug Regimen: (Hyper-CVAD) [[Cyclophosphamide]], {{and}} [[Vincristine]], {{and}} [[Doxorubicin]], {{and}} [[Dexamethasone]], {{and}} [[Methotrexate]], {{and}} [[Cytarabine]] | ||
'''CNS prophylaxis''' | |||
* There is a high risk that Burkitt's lymphoma will spread to the central nervous system (CNS) | |||
* CNS prophylaxis may involve giving [[intrathecal]] chemotherapy high doses of systemic therapy, or both methods may be used | |||
* [[Methotrexate]] and [[Cytarabine]] are the drugs used most often for CNS prophylaxis | |||
===Biological therapy=== | ===Biological therapy=== | ||
* [[Monoclonal antibodies]] are a type of biological therapy that is effective in treating Burkitt's lymphoma | * [[Monoclonal antibodies]] are a type of biological therapy that is effective in treating Burkitt's lymphoma | ||
* [[Rituximab]] may be added to each of the above chemotherapy regimens | * [[Rituximab]] may be added to each of the above chemotherapy regimens | ||
===Stem cell transplant=== | ===Stem cell transplant=== | ||
* A stem cell transplant may be offered to some people with Burkitt's lymphoma if their lymphoma returns or relapses after treatment | * A stem cell transplant may be offered to some people with Burkitt's lymphoma if their lymphoma returns or relapses after treatment | ||
Revision as of 20:42, 28 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]
Overview
The predominant therapy for Burkitt's lymphoma is chemotherapy. Adjunctive immunotherapy and stem cell transplantation may be required.
Medical Therapy
The predominant therapy for Burkitt's lymphoma is chemotherapy. Adjunctive immunotherapy and stem cell transplantation may be required.[1]
Chemotherapy
- Drug Regimen: (CODOX-M) Cyclophosphamide, AND Vincristine, AND Doxorubicin, AND Methotrexate
- Drug Regimen: (IVAC) Ifosfamide PLUS Mesna, AND Etoposide, AND Cytarabine
- Drug Regimen: (Hyper-CVAD) Cyclophosphamide, AND Vincristine, AND Doxorubicin, AND Dexamethasone, AND Methotrexate, AND Cytarabine
CNS prophylaxis
- There is a high risk that Burkitt's lymphoma will spread to the central nervous system (CNS)
- CNS prophylaxis may involve giving intrathecal chemotherapy high doses of systemic therapy, or both methods may be used
- Methotrexate and Cytarabine are the drugs used most often for CNS prophylaxis
Biological therapy
- Monoclonal antibodies are a type of biological therapy that is effective in treating Burkitt's lymphoma
- Rituximab may be added to each of the above chemotherapy regimens
Stem cell transplant
- A stem cell transplant may be offered to some people with Burkitt's lymphoma if their lymphoma returns or relapses after treatment
References
- ↑ Burkitt lymphoma. Canadian Cancer Society. http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/burkitt-lymphoma/?region=on Accessed on September 28, 2015