Thymoma staging: Difference between revisions
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|style="background: #F0F0F0;"| Macroscopically completely encapsulated and microscopically no capsular invasion | |style="background: #F0F0F0;"| Macroscopically completely encapsulated and microscopically no capsular invasion | ||
|- | |- | ||
| style="background: #F0F0F0;" align=center | '''T2''' || Macroscopically adhesion or invasion into surrounding fatty tissue or mediastinal pleura, <BR> or microscopic invasion into capsule | | style="background: #F0F0F0;" align=center | '''T2''' | ||
|style="background: #F0F0F0;"| Macroscopically adhesion or invasion into surrounding fatty tissue or mediastinal pleura, <BR> or microscopic invasion into capsule | |||
|- | |- | ||
| style="background: #F0F0F0;" align=center | '''T3''' || Invasion into neighboring organs, such as pericardium, great vessels, and lung | | style="background: #F0F0F0;" align=center | '''T3''' | ||
|style="background: #F0F0F0;"| Invasion into neighboring organs, such as pericardium, great vessels, and lung | |||
|- | |- | ||
| style="background: #F0F0F0;" align=center | '''T4''' || Pleural or pericardial dissemination | | style="background: #F0F0F0;" align=center | '''T4''' | ||
|style="background: #F0F0F0;"| Pleural or pericardial dissemination | |||
|- | |- | ||
| style="background: #F0F0F0;" rowspan=4 align=center | '''N factor''' || style="background: #F0F0F0;" align=center | '''N0''' || No lymph node metastasis | | style="background: #F0F0F0;" rowspan=4 align=center | '''N factor''' || style="background: #F0F0F0;" align=center | '''N0''' | ||
|style="background: #F0F0F0;"| No lymph node metastasis | |||
|- | |- | ||
| style="background: #F0F0F0;" align=center | '''N1''' || Metastasis to anterior mediastinal lymph nodes | | style="background: #F0F0F0;" align=center | '''N1''' | ||
|style="background: #F0F0F0;"| Metastasis to anterior mediastinal lymph nodes | |||
|- | |- | ||
| style="background: #F0F0F0;" align=center | '''N2''' || Metastasis to intrathoracic lymphnodes except anterior mediastinal lymph nodes | | style="background: #F0F0F0;" align=center | '''N2''' | ||
|style="background: #F0F0F0;"| Metastasis to intrathoracic lymphnodes except anterior mediastinal lymph nodes | |||
|- | |- | ||
| style="background: #F0F0F0;" align=center | '''N3''' || Metastasis to extrathoracic lymphnodes | | style="background: #F0F0F0;" align=center | '''N3''' | ||
|style="background: #F0F0F0;"| Metastasis to extrathoracic lymphnodes | |||
|- | |- | ||
| style="background: #F0F0F0;" style="background: #F0F0F0;" rowspan=4 align=center | '''M factor''' || style="background: #F0F0F0;" align=center | '''M0''' || No hematogenous metastasis | | style="background: #F0F0F0;" style="background: #F0F0F0;" rowspan=4 align=center | '''M factor''' || style="background: #F0F0F0;" align=center | '''M0''' | ||
|style="background: #F0F0F0;"| No hematogenous metastasis | |||
|- | |- | ||
| style="background: #F0F0F0;" align=center | '''M1''' || Hematogenous metastasis | | style="background: #F0F0F0;" align=center | '''M1''' | ||
|style="background: #F0F0F0;"| Hematogenous metastasis | |||
|- | |- | ||
|} | |} | ||
Revision as of 21:10, 28 September 2015
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Thymoma Microchapters |
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Diagnosis |
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Case Studies |
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Thymoma staging On the Web |
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American Roentgen Ray Society Images of Thymoma staging |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Amr Marawan, M.D. [2]
Overview
The thymic epithelial tumor staging system was initially proposed by Bergh and his colleagues in 1978,[1] modified by Wilkins and Castleman in 1979,[2] and further developed by Masaoka et al. in 1981.[3][4] Modified Masaoka staging grouped with TNM classification is the most widely adopted system for thymic epithelial tumors currently in use.
Modified Masaoka Clinical Staging of Thymoma
| Stage | Description |
|---|---|
| I | Macroscopically and microscopically completely encapsulated |
| II | A. Microscopic transcapsular invasion B. Macroscopic invasion into surrounding fatty tissue or grossly adherent to but not through mediastinal pleura or pericardium |
| III | Macroscopic invasion into neighboring organs (ie, pericardium, great vessels, lung) A. Without invasion of great vessels B. With invasion of great vessels |
| IV | A. Pleural or pericardial dissemination B. Lymphogenous or hematogenous metastasis |
TNM Classification of Thymic Epithelial Tumors
| T/N/M Stage | Description | |
|---|---|---|
| T factor | T1 | Macroscopically completely encapsulated and microscopically no capsular invasion |
| T2 | Macroscopically adhesion or invasion into surrounding fatty tissue or mediastinal pleura, or microscopic invasion into capsule | |
| T3 | Invasion into neighboring organs, such as pericardium, great vessels, and lung | |
| T4 | Pleural or pericardial dissemination | |
| N factor | N0 | No lymph node metastasis |
| N1 | Metastasis to anterior mediastinal lymph nodes | |
| N2 | Metastasis to intrathoracic lymphnodes except anterior mediastinal lymph nodes | |
| N3 | Metastasis to extrathoracic lymphnodes | |
| M factor | M0 | No hematogenous metastasis |
| M1 | Hematogenous metastasis | |
| Masaoka Stage | T factor | N factor | M factor |
|---|---|---|---|
| Stage I | T1 | N0 | M0 |
| Stage II | T2 | N0 | M0 |
| Stage III | T3 | N0 | M0 |
| Stage IVa | T4 | N0 | M0 |
| Stage IVb | Any T | N1, N2, or N3 | M0 |
| Any T | Any N | M1 |
Previously Reported Staging System
| Stage | Description |
|---|---|
| I | Macroscopically completely encapsulated and microscopically no capsular invasion |
| II | 1. Macroscopic invasion into surrounding fatty tissue or mediastinal pleura 2. Microscopic invasion into capsule |
| III | Macroscopic invasion into neighboring organ (ie, pericardium, great vessels, or lung) |
| IVa | Pleural or pericardial dissemination |
| IVb | Lymphogenous or hematogenous metastasis |
| Author | Stage | Description |
|---|---|---|
| Bergh et al. | I | Intact capsule or growth within the capsule |
| II | Pericapsular growth into the mediastinal fat tissue | |
| III | Invasive growth into the surrounding organs and/or intrathoracic metastases | |
| Wilkins et al. | I | Intact capsule or growth within the capsule |
| II | Pericapsular growth into the mediastinal fat tissue or adjacent pleura or pericardium | |
| III | Invasive growth into the surrounding organs and/or intrathoracic metastases |
References
- ↑ 1.0 1.1 Bergh, NP.; Gatzinsky, P.; Larsson, S.; Lundin, P.; Ridell, B. (1978). "Tumors of the thymus and thymic region: I. Clinicopathological studies on thymomas". Ann Thorac Surg. 25 (2): 91–8. PMID 626543. Unknown parameter
|month=ignored (help) - ↑ 2.0 2.1 Wilkins, EW.; Castleman, B. (1979). "Thymoma: a continuing survey at the Massachusetts General Hospital". Ann Thorac Surg. 28 (3): 252–6. PMID 485626. Unknown parameter
|month=ignored (help) - ↑ 3.0 3.1 Masaoka, A.; Monden, Y.; Nakahara, K.; Tanioka, T. (1981). "Follow-up study of thymomas with special reference to their clinical stages". Cancer. 48 (11): 2485–92. PMID 7296496. Unknown parameter
|month=ignored (help) - ↑ Kondo, K. (2005). "Invited commentary". Ann Thorac Surg. 80 (6): 2000–1. doi:10.1016/j.athoracsur.2005.08.053. PMID 16305832. Unknown parameter
|month=ignored (help) - ↑ Masaoka, A.; Yamakawa, Y.; Niwa, H.; Fukai, I.; Saito, Y.; Tokudome, S.; Nakahara, K.; Fujii, Y. (1994). "Thymectomy and malignancy". Eur J Cardiothorac Surg. 8 (5): 251–3. PMID 8043287.
- ↑ Sinha Hikim AP, Hoffer AP (1987). "Quantitative analysis of germ cells and Leydig cells in rat made infertile with gossypol". Contraception. 35 (4): 395–408. PMID 3621939.
- ↑ Tsuchiya R, Koga K, Matsuno Y, Mukai K, Shimosato Y (1994). "Thymic carcinoma: proposal for pathological TNM and staging". Pathol Int. 44 (7): 505–12. PMID 7921194.