Medulloblastoma pathophysiology: Difference between revisions
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==Overview== | ==Overview== | ||
== | ==Pathogenesis== | ||
Medulloblastomas usually form in the fourth ventricle, between the brainstem and the cerebellum. Tumors with similar appearance and characteristics originate in other parts of the brain, but they are not identical to medulloblastoma. <ref>Roger Packer M.D, [http://virtualtrials.com/medullo.cfm Medulloblastoma] Clinical Trials and Noteworthy Treatments for Brain Tumors 2002.</ref> | Medulloblastomas usually form in the fourth ventricle, between the brainstem and the cerebellum. Tumors with similar appearance and characteristics originate in other parts of the brain, but they are not identical to medulloblastoma. <ref>Roger Packer M.D, [http://virtualtrials.com/medullo.cfm Medulloblastoma] Clinical Trials and Noteworthy Treatments for Brain Tumors 2002.</ref> | ||
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It is currently thought that medulloblastoma arises from cerebellar "stem cells" that have been prevented from dividing and differentiating into their normal cell types. This accounts from the varying histologic variants seen on biopsy. '''Rosette''' formation is highly characteristic of medulloblastoma and is seen in up to half of the cases. | It is currently thought that medulloblastoma arises from cerebellar "stem cells" that have been prevented from dividing and differentiating into their normal cell types. This accounts from the varying histologic variants seen on biopsy. '''Rosette''' formation is highly characteristic of medulloblastoma and is seen in up to half of the cases. | ||
==Genetics== | |||
Molecular genetics reveal a loss of genetic information on the distal part of chromosome 17, distal to the ''[[p53]]'' gene, possibly accounting for the neoplastic transformation of the undifferentiated cerebellar cells. Medulloblastomas are also seen in [[Gorlin syndrome]] as well as [[Turcot syndrome]]. Another research has strongly implicated the [[JC virus]], the virus that causes [[progressive multifocal leukoencephalopathy|multifocal leukoencephalopathy]]. | Molecular genetics reveal a loss of genetic information on the distal part of chromosome 17, distal to the ''[[p53]]'' gene, possibly accounting for the neoplastic transformation of the undifferentiated cerebellar cells. Medulloblastomas are also seen in [[Gorlin syndrome]] as well as [[Turcot syndrome]]. Another research has strongly implicated the [[JC virus]], the virus that causes [[progressive multifocal leukoencephalopathy|multifocal leukoencephalopathy]]. | ||
==Gross Pathology== | |||
Histologically, the tumor is solid, pink-gray in color, and is well circumscribed. | Histologically, the tumor is solid, pink-gray in color, and is well circumscribed. | ||
==Mircoscopic Pathology== | |||
The tumor is very cellular, many mitoses, little cytoplasm, and has the tendency to form clusters and rosettes. | The tumor is very cellular, many mitoses, little cytoplasm, and has the tendency to form clusters and rosettes. | ||
==References== | ==References== | ||
Revision as of 23:10, 28 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]
Overview
Pathogenesis
Medulloblastomas usually form in the fourth ventricle, between the brainstem and the cerebellum. Tumors with similar appearance and characteristics originate in other parts of the brain, but they are not identical to medulloblastoma. [1]
Although it is thought that medulloblastomas originate from immature or embryonal cells at their earliest stage of development, the exact cell of origin, or "medulloblast" has yet to be identified.
It is currently thought that medulloblastoma arises from cerebellar "stem cells" that have been prevented from dividing and differentiating into their normal cell types. This accounts from the varying histologic variants seen on biopsy. Rosette formation is highly characteristic of medulloblastoma and is seen in up to half of the cases.
Genetics
Molecular genetics reveal a loss of genetic information on the distal part of chromosome 17, distal to the p53 gene, possibly accounting for the neoplastic transformation of the undifferentiated cerebellar cells. Medulloblastomas are also seen in Gorlin syndrome as well as Turcot syndrome. Another research has strongly implicated the JC virus, the virus that causes multifocal leukoencephalopathy.
Gross Pathology
Histologically, the tumor is solid, pink-gray in color, and is well circumscribed.
Mircoscopic Pathology
The tumor is very cellular, many mitoses, little cytoplasm, and has the tendency to form clusters and rosettes.
References
- ↑ Roger Packer M.D, Medulloblastoma Clinical Trials and Noteworthy Treatments for Brain Tumors 2002.