Burkitt's lymphoma classification

Burkitt's lymphoma Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Burkitt's lymphoma from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Diagnostic Study Of Choice
Staging
History and Symptoms
Physical Examination
Laboratory Findings
X Ray Findings
CT
MRI
Biopsy
Other Imaging Studies
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Burkitt's lymphoma classification On the Web
Most recent articles
cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Burkitt's lymphoma classification All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Burkitt's lymphoma classification
CDC on Burkitt's lymphoma classification
Burkitt's lymphoma classification in the news
Blogs on Burkitt's lymphoma classification
Directions to Hospitals Treating Burkitt's lymphoma
Risk calculators and risk factors for Burkitt's lymphoma classification

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]

Overview

Burkitt's lymphoma may be classified according to WHO classification into 3 clinical variants: endemic Burkitt's lymphoma, sporadic Burkitt's lymphoma, and immunodeficiency-associated Burkitt's lymphoma.

WHO Classification based on the geographic distribution and clinical presentation

Burkitt's lymphoma may be classified according to WHO classification into 3 clinical variants :

• Endemic Burkitt's lymphoma
• Sporadic Burkitt's lymphoma
• Immunodeficiency-associated Burkitt's lymphoma

By morphology (i.e. microscopic appearance) or immunophenotype, it is almost impossible to differentiate these three clinical variants. Immunodeficiency-associated Burkitt's lymphoma may demonstrate more plasmacytic appearance or more pleomorphism, but these features are not specific.

WHO classification based on the geographic distribution and clinical presentation

Name	Description
Endemic Burkitt's lymphoma (African Burkitt's lymphoma)	The most common childhood cancer in Africa Almost always associated with Epstein-Barr virus infection Characteristically involves the jaw or other facial bone, distal ileum, cecum, ovaries, kidney, or the breast
Sporadic Burkitt's lymphoma (Non-African or Non-endemic Burkitt's lymphoma)	The most common type of Burkitt's lymphoma in North America and European countries Sometimes associated with the Epstein-Barr virus, but in many cases this virus is not present Non-Hodgkin's lymphoma, which includes Burkitt's, accounts for 30-50% of childhood lymphoma Ileo-cecal region is the common site of involvement Most often starts in the abdomen, but can also start in the ovaries, testicles, kidneys or other organs Jaw is less commonly involved, comparing with the endemic variant Can also involve the pleura lining the lung, central nervous system (CNS) and, uncommonly, the breast
Immunodeficiency-associated Burkitt's lymphoma	Tends to occur in people with weakened immune systems, typically those with HIV infection Incidence appears to be dropping because of antiretroviral therapy About 30–40% of cases are associated with the Epstein-Barr virus

References

Template:WikiDoc Sources