Pituitary adenoma pathophysiology: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
No edit summary |
||
| Line 6: | Line 6: | ||
*Over half of all adenomas are secretory | *Over half of all adenomas are secretory | ||
*Although even when this is the case this may not be the cause of presentation. | *Although even when this is the case this may not be the cause of presentation. | ||
*Most of the cases presenting due to mass effect are due to non-secreting macroadenomas and the most common structure to be compressed by a macroadenoma is the [[optic chiasm]]. | *Most of the cases presenting due to mass effect are due to non-secreting macroadenomas and the most common structure to be compressed by a macroadenoma is the [[optic chiasm]]. | ||
* | *Larger adenoma can lead to hormonal imbalance due to mass effect rather than secretion. | ||
*Hypopituitarism or moderately elevated prolactin are both seen, the later due to stalk effect; prolactin release (unlike other pituitary hormones) is tonically inhibited by prolactin inhibitory hormone (a.k.a. dopamine) and as such compression of the pituitary infundibulum can result in elevation of systemic prolactin levels due to interruption of normal inhibition.<ref name=radio>Pituitary adenoma. Dr Amir Rezaee and Dr Yuranga Weerakkody. Radiopaedia.org 2015.http://radiopaedia.org/articles/pituitary-adenoma</ref> | |||
Revision as of 14:22, 29 September 2015
|
Pituitary adenoma Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Pituitary adenoma pathophysiology On the Web |
|
American Roentgen Ray Society Images of Pituitary adenoma pathophysiology |
|
Risk calculators and risk factors for Pituitary adenoma pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ahmad Al Maradni, M.D. [2]
Overview
Pathophysiology
- Over half of all adenomas are secretory
- Although even when this is the case this may not be the cause of presentation.
- Most of the cases presenting due to mass effect are due to non-secreting macroadenomas and the most common structure to be compressed by a macroadenoma is the optic chiasm.
- Larger adenoma can lead to hormonal imbalance due to mass effect rather than secretion.
- Hypopituitarism or moderately elevated prolactin are both seen, the later due to stalk effect; prolactin release (unlike other pituitary hormones) is tonically inhibited by prolactin inhibitory hormone (a.k.a. dopamine) and as such compression of the pituitary infundibulum can result in elevation of systemic prolactin levels due to interruption of normal inhibition.[1]
References
- ↑ Pituitary adenoma. Dr Amir Rezaee and Dr Yuranga Weerakkody. Radiopaedia.org 2015.http://radiopaedia.org/articles/pituitary-adenoma