Carcinoid syndrome laboratory tests: Difference between revisions

Jump to navigation Jump to search
No edit summary
Line 4: Line 4:


==Overview==
==Overview==
Laboratory findings consistent with the diagnosis of carcinoid tumor include urinary 5-hydroxyindoleacetic acid (5-HIAA) and plasma levels of CgA levels.
Laboratory findings consistent with the diagnosis of carcinoid syndrome include an elevated urinary 5-hydroxyindoleacetic acid (5-HIAA) and plasma levels of CgA levels.<ref name=diagnostics>Diagnostics: Biochemical Markers, Imaging, and Approach. National cancer institute. http://www.cancer.gov/types/gi-carcinoid-tumors/hp/gi-carcinoid-treatment-pdq</ref>


==Laboratory Findings==
==Laboratory Findings==
*Biochemical investigations in the diagnosis of gastrointestinal carcinoids include the use of 24-hour urinary [[5-hydroxyindoleacetic acid]] (5-HIAA) collection, which has a specificity of approximately 88%, although the sensitivity is reported to be as low as 35%.<ref> Diagnostics: Biochemical Markers, Imaging, and Approach
Laboratory findings consistent with the diagnosis of carcinoid syndrome include an elevated urinary 5-hydroxyindoleacetic acid (5-HIAA) and plasma levels of CgA levels.
*Testing for elevated urinary 5-hydroxyindoleacetic acid (5-HIAA) has a specificity of approximately 88%, although the sensitivity is reported to be as low as 35%.<ref name=diagnostics>Diagnostics: Biochemical Markers, Imaging, and Approach. National cancer institute. http://www.cancer.gov/types/gi-carcinoid-tumors/hp/gi-carcinoid-treatment-pdq</ref>
. General Information About Gastrointestinal (GI) Carcinoid Tumors
. General Information About Gastrointestinal (GI) Carcinoid Tumors
. http://www.cancer.gov/types/gi-carcinoid-tumors/hp/gi-carcinoid-treatment-pdq#link/_47_toc Accessed on September 21, 2015</ref>
. http://www.cancer.gov/types/gi-carcinoid-tumors/hp/gi-carcinoid-treatment-pdq#link/_47_toc Accessed on September 21, 2015</ref>
*Plasma levels of CgA are very sensitive markers of carcinoids, they are nonspecific because they are also elevated in other types of [[neuroendocrinal tumors]], such as [[pancreatic]] and small cell lung carcinomas.
*Plasma levels of CgA are very sensitive markers of carcinoids, they are nonspecific because they are also elevated in other types of neuroendocrinal tumors, such as [[pancreatic]] and small cell lung carcinomas.


*Many other biochemical markers are associated with neuroendocrinal tumors— including substance P, neurotensin, [[bradykinin]], [[human chorionic gonadotropin]], neuropeptide L, and [[pancreatic polypeptide]]— but none match the specificity or predictive value of 5-HIAA or CgA.
*Many other biochemical markers are associated with neuroendocrinal tumors— including substance P, neurotensin, [[bradykinin]], [[human chorionic gonadotropin]], neuropeptide L, and [[pancreatic polypeptide]]— but none match the specificity or predictive value of 5-HIAA or CgA.

Revision as of 19:34, 29 September 2015

Carcinoid syndrome Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Carcinoid Syndrome from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Staging

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

Chest X Ray

CT

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Carcinoid syndrome laboratory tests On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Carcinoid syndrome laboratory tests

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Carcinoid syndrome laboratory tests

CDC on Carcinoid syndrome laboratory tests

Carcinoid syndrome laboratory tests in the news

Blogs on Carcinoid syndrome laboratory tests

Directions to Hospitals Treating Carcinoid syndrome

Risk calculators and risk factors for Carcinoid syndrome laboratory tests

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2]

Overview

Laboratory findings consistent with the diagnosis of carcinoid syndrome include an elevated urinary 5-hydroxyindoleacetic acid (5-HIAA) and plasma levels of CgA levels.[1]

Laboratory Findings

Laboratory findings consistent with the diagnosis of carcinoid syndrome include an elevated urinary 5-hydroxyindoleacetic acid (5-HIAA) and plasma levels of CgA levels.

  • Testing for elevated urinary 5-hydroxyindoleacetic acid (5-HIAA) has a specificity of approximately 88%, although the sensitivity is reported to be as low as 35%.[1]

. General Information About Gastrointestinal (GI) Carcinoid Tumors . http://www.cancer.gov/types/gi-carcinoid-tumors/hp/gi-carcinoid-treatment-pdq#link/_47_toc Accessed on September 21, 2015</ref>

  • Plasma levels of CgA are very sensitive markers of carcinoids, they are nonspecific because they are also elevated in other types of neuroendocrinal tumors, such as pancreatic and small cell lung carcinomas.

References

  1. 1.0 1.1 Diagnostics: Biochemical Markers, Imaging, and Approach. National cancer institute. http://www.cancer.gov/types/gi-carcinoid-tumors/hp/gi-carcinoid-treatment-pdq


Template:WikiDoc Sources