Angiomyolipoma other diagnostic studies: Difference between revisions
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*SMA positive | *SMA positive | ||
*CD117 positive/negative | *CD117 positive/negative | ||
* | *Ki-67:<ref name=pmid18839327>{{Cite journal | last1 = Ooi | first1 = SM. | last2 = Vivian | first2 = JB. | last3 = Cohen | first3 = RJ. | title = The use of the Ki-67 marker in the pathological diagnosis of the epithelioid variant of renal angiomyolipoma. | journal = Int Urol Nephrol | volume = 41 | issue = 3 | pages = 559-65 | month = | year = 2009 | doi = 10.1007/s11255-008-9473-1 | PMID = 18839327 }}</ref> | ||
**Epithelioid variant of [[angiomyolipoma]] positive | **Epithelioid variant of [[angiomyolipoma]] positive | ||
**Conventional angiomyolipoma negative | **Conventional angiomyolipoma negative | ||
Revision as of 19:01, 29 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Faizan Sheraz, M.D. [2]
Overview
CT guided biopsy is diagnostic of angiomyolipoma.
Biopsy Findings
Biopsy findings of angiomyolipoma include:
Microscopic Features
Microscopic features of angiomyolipoma are:
- Smooth muscle
- Adipose tissue - not always present[1] - key feature
- Abundant blood vessels
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Cytologic
Cytologic features of angiomyolipoma include:[1]
Immunohistochemistry
Immunohistochemistry markers of angiomyolipoma include:
- Melanocytic markers positive[2]
- HMB-45 positive in all cases (15/15)[3]
- Melan A positive in ~87% of cases (13/15)
- Epithelial markers negative[2]
- EMA
- AE1/AE3
- SMA positive
- CD117 positive/negative
- Ki-67:[4]
- Epithelioid variant of angiomyolipoma positive
- Conventional angiomyolipoma negative
References
- ↑ 1.0 1.1 Crapanzano, JP. (2005). "Fine-needle aspiration of renal angiomyolipoma: cytological findings and diagnostic pitfalls in a series of five cases". Diagn Cytopathol. 32 (1): 53–7. doi:10.1002/dc.20179. PMID 15584043. Unknown parameter
|month=ignored (help) - ↑ 2.0 2.1 Template:Ref GUP
- ↑ Esheba, Gel S.; Esheba, Nel S. (2013). "Angiomyolipoma of the kidney: clinicopathological and immunohistochemical study". J Egypt Natl Canc Inst. 25 (3): 125–34. doi:10.1016/j.jnci.2013.05.002. PMID 23932749. Unknown parameter
|month=ignored (help) - ↑ Ooi, SM.; Vivian, JB.; Cohen, RJ. (2009). "The use of the Ki-67 marker in the pathological diagnosis of the epithelioid variant of renal angiomyolipoma". Int Urol Nephrol. 41 (3): 559–65. doi:10.1007/s11255-008-9473-1. PMID 18839327.