Angiomyolipoma other diagnostic studies: Difference between revisions
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*Adipose tissue - not always present<ref name=pmid15584043>{{Cite journal | last1 = Crapanzano | first1 = JP. | title = Fine-needle aspiration of renal angiomyolipoma: cytological findings and diagnostic pitfalls in a series of five cases. | journal = Diagn Cytopathol | volume = 32 | issue = 1 | pages = 53-7 | month = Jan | year = 2005 | doi = 10.1002/dc.20179 | PMID = 15584043 }}</ref> - '''key feature''' | *Adipose tissue - not always present<ref name=pmid15584043>{{Cite journal | last1 = Crapanzano | first1 = JP. | title = Fine-needle aspiration of renal angiomyolipoma: cytological findings and diagnostic pitfalls in a series of five cases. | journal = Diagn Cytopathol | volume = 32 | issue = 1 | pages = 53-7 | month = Jan | year = 2005 | doi = 10.1002/dc.20179 | PMID = 15584043 }}</ref> - '''key feature''' | ||
*Abundant [[blood vessel]]s | *Abundant [[blood vessel]]s | ||
<gallery> | |||
Image: | |||
Renal angiomyolipoma (1).jpg|Histopathologic image of renal angiomyolipoma. Nephrectomy specimen. H & E stain. | |||
Image:Renal angiomyolipoma (2).jpg|Histopathologic image of renal angiomyolipoma. Nephrectomy specimen. H & E stain. | |||
Image:Renal angiomyolipoma (3).jpg|Histopathologic image of renal angiomyolipoma. Nephrectomy specimen. H & E stain. | |||
Image:Renal angiomyolipoma (4) HMB-45 immunostain.JPG|Histopathologic image of renal angiomyolipoma. Nephrectomy specimen. HMB-45 immunostain. | |||
</gallery> | |||
===Cytologic=== | ===Cytologic=== | ||
Revision as of 13:11, 1 October 2015
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Angiomyolipoma Microchapters |
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Diagnosis |
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Angiomyolipoma other diagnostic studies On the Web |
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Risk calculators and risk factors for Angiomyolipoma other diagnostic studies |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Faizan Sheraz, M.D. [2]
Overview
CT guided biopsy is diagnostic of angiomyolipoma.
Biopsy Findings
Biopsy findings of angiomyolipoma include:
Microscopic Features
Microscopic features of angiomyolipoma are:
- Smooth muscle
- Adipose tissue - not always present[1] - key feature
- Abundant blood vessels
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Histopathologic image of renal angiomyolipoma. Nephrectomy specimen. H & E stain.
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Histopathologic image of renal angiomyolipoma. Nephrectomy specimen. H & E stain.
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Histopathologic image of renal angiomyolipoma. Nephrectomy specimen. H & E stain.
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Histopathologic image of renal angiomyolipoma. Nephrectomy specimen. HMB-45 immunostain.
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_HMB-45_immunostain.JPG)
Cytologic
Cytologic features of angiomyolipoma include:[1]
Immunohistochemistry
Immunohistochemistry markers of angiomyolipoma include:
- Melanocytic markers positive[2]
- HMB-45 positive in all cases (15/15)[3]
- Melan A positive in ~87% of cases (13/15)
- Epithelial markers negative[2]
- EMA
- AE1/AE3
- SMA positive
- CD117 positive/negative
- Ki-67:[4]
- Epithelioid variant of angiomyolipoma positive
- Conventional angiomyolipoma negative
References
- ↑ 1.0 1.1 Crapanzano, JP. (2005). "Fine-needle aspiration of renal angiomyolipoma: cytological findings and diagnostic pitfalls in a series of five cases". Diagn Cytopathol. 32 (1): 53–7. doi:10.1002/dc.20179. PMID 15584043. Unknown parameter
|month=ignored (help) - ↑ 2.0 2.1 Template:Ref GUP
- ↑ Esheba, Gel S.; Esheba, Nel S. (2013). "Angiomyolipoma of the kidney: clinicopathological and immunohistochemical study". J Egypt Natl Canc Inst. 25 (3): 125–34. doi:10.1016/j.jnci.2013.05.002. PMID 23932749. Unknown parameter
|month=ignored (help) - ↑ Ooi, SM.; Vivian, JB.; Cohen, RJ. (2009). "The use of the Ki-67 marker in the pathological diagnosis of the epithelioid variant of renal angiomyolipoma". Int Urol Nephrol. 41 (3): 559–65. doi:10.1007/s11255-008-9473-1. PMID 18839327.