Vulvar cancer pathophysiology: Difference between revisions
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| Squamous cell carcinoma of vulva|| | | Squamous cell carcinoma of vulva|| | ||
*Most lesions originate in the labia, primarily the [[labia majora]]. Other areas affected are the [[clitoris]], and [[fourchette]], and the local glands | *Most lesions originate in the labia, primarily the [[labia majora]]. Other areas affected are the [[clitoris]], and [[fourchette]], and the local glands | ||
* unifocal | * unifocal | ||
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* Eosinophilia | * Eosinophilia | ||
* Extra large nuclei/bizarre nuclei | * Extra large nuclei/bizarre nuclei | ||
* Inflammation (lymphocytes, plasma cells) | * Inflammation (lymphocytes, plasma cells) | ||
* Long rete ridges | * Long rete ridges | ||
* Numerous beeds/blobs of epithelial cells that seem unlikely to be rete ridges | * Numerous beeds/blobs of epithelial cells that seem unlikely to be rete ridges | ||
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|Basal cell carcinoma || | |Basal cell carcinoma of vulva|| | ||
*pearly nodule with telangiectasias | *pearly nodule with telangiectasias | ||
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* Basaloid cells - similar in appearance to basal cells: | * Basaloid cells - similar in appearance to basal cells: | ||
* Moderate blue/grey cytoplasm. | * Moderate blue/grey cytoplasm. | ||
* Dark ovoid/ellipsoid nucleus with uniform chromatin | * Dark ovoid/ellipsoid nucleus with uniform chromatin | ||
* Palisading of cells at the edge of the cell nests | * Palisading of cells at the edge of the cell nests | ||
* Artefactual separation of cells (forming the nests) from the underlying stroma - key feature | * Artefactual separation of cells (forming the nests) from the underlying stroma - key feature | ||
* Surrounded by blue (myxoid) stroma - key feature | * Surrounded by blue (myxoid) stroma - key feature | ||
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| Vulvar melanoma|| | | Vulvar melanoma|| | ||
Revision as of 14:46, 30 September 2015
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Vulvar cancer Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Vulvar cancer pathophysiology On the Web |
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American Roentgen Ray Society Images of Vulvar cancer pathophysiology |
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Risk calculators and risk factors for Vulvar cancer pathophysiology |
Overview
Vulvar cancer, a malignant invasive growth in the vulva, accounts for about 4 % of all gynecological cancers and typically affects women in later life. It is estimated that in the United States in 2006 about 3,740 new cases will be diagnosed and about 880 women will die as a result of vulvar cancer.[1] Vulvar carcinoma is separated from vulvar intraepithelial neoplasia (VIN), a non-invasive lesion of the epithelium that can progress via carcinoma-in-situ to squamous cell cancer, and from Paget disease of the vulva.
Types
Table 31-1. Histologic Subtypes of Vulvar Cancer[2][3][4][5]
1. Vulvar carcinomas
- Squamous cell carcinoma
- Basal cell carcinoma
- Vulvar Paget disease
- Adenocarcinoma
- Transitional cell carcinoma
- Verrucous carcinoma
- Merkel cell tumors
- Verrucous carcinoma
2. Vulvar malignant melanoma
3. Vulvar sarcoma
- Leiomyosarcoma
- Malignant fibrous histiocytoma
- Epithelial sarcoma
| Vulvar carcinomas Subtype | Features on Gross Pathology | Features on Histopathological Microscopic Analysis |
| Squamous cell carcinoma of vulva |
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| Basal cell carcinoma of vulva |
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| Vulvar melanoma |
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References
- ↑ American Cancer Society (2006). "Cancer facts and Figures 2006" (PDF). Retrieved 2006-10-13.
- ↑ Hoffman, Barbara (2012). Williams gynecology. New York: McGraw-Hill Medical. ISBN 9780071716727.
- ↑ Malignant melanoma. Libre pathology. http://librepathology.org/wiki/index.php/Malignant_melanoma. URL Accessed on September 30, 2015
- ↑ Basal cell carcinoma . Libre pathology. http://librepathology.org/wiki/index.php/Basal_cell_carcinoma. URL Accessed on September 30, 2015
- ↑ Squamous cell carcinoma. Libre pathology. http://librepathology.org/wiki/index.php/Squamous_cell_carcinoma. URL Accessed on September 30, 2015