Medulloblastoma medical therapy: Difference between revisions
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===Risk Stratification Criteria=== | ===Risk Stratification Criteria=== | ||
* The risk stratification criteria may help predict the protocol that should be used for the treatment of medulloblastoma patients. | |||
* The table below demonstrates the risk stratification criteria for medulloblastoma patients:<ref name="pmid23245832">{{cite journal| author=Bartlett F, Kortmann R, Saran F| title=Medulloblastoma. | journal=Clin Oncol (R Coll Radiol) | year= 2013 | volume= 25 | issue= 1 | pages= 36-45 | pmid=23245832 | doi=10.1016/j.clon.2012.09.008 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23245832 }} </ref><ref name="b">Medulloblastoma staging. Wikibooks(2015) https://en.wikibooks.org/wiki/Radiation_Oncology/Medulloblastoma/Staging Accessed on September, 28th 2015)</ref> | |||
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! style="background: #4479BA; width: 150px;" | {{fontcolor|#FFF|Parameters}} | |||
! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|'''Standard Risk Group'''}} | |||
! style="background: #4479BA; width: 450px;" | {{fontcolor|#FFF|'''High Risk Group'''}} | |||
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'''Age''' | |||
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:::::Patients older than 3 years of age | |||
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:::::Patients younger than 3 years of age | |||
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'''Extent of previous surgical resection''' | |||
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::::<1.5 cm² residual tumor after resection | |||
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::Subtotal resection '''or''' >1.5 cm² residual tumor after resection | |||
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'''Tumor stage''' | |||
| style="padding: 5px 5px; background: #F5F5F5;" | | |||
:::M0 stage confirmed by [[MRI]] and [[CSF]] sampling | |||
| style="padding: 5px 5px; background: #F5F5F5;" | | |||
:::M1-M3 stage '''or''' presence of [[leptomeningeal]] seeding | |||
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===Radiation Therapy=== | ===Radiation Therapy=== | ||
Revision as of 03:37, 2 October 2015
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Medulloblastoma Microchapters |
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Diagnosis |
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Treatment |
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Case studies |
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Medulloblastoma medical therapy On the Web |
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American Roentgen Ray Society Images of Medulloblastoma medical therapy |
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Risk calculators and risk factors for Medulloblastoma medical therapy |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]
Overview
Medical Therapy
- The algorithm below summarize the management approach for medulloblastoma patients:[1]
Optimal surgical excision | |||||||||||||||||||
Histopathological analysis | |||||||||||||||||||
Detailed staging | |||||||||||||||||||
Risk stratification | |||||||||||||||||||
Radiotherapy and chemotherapy according to the risk stratification criteria | |||||||||||||||||||
Risk Stratification Criteria
- The risk stratification criteria may help predict the protocol that should be used for the treatment of medulloblastoma patients.
- The table below demonstrates the risk stratification criteria for medulloblastoma patients:[2][3]
| Parameters | Standard Risk Group | High Risk Group |
|---|---|---|
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Age |
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Extent of previous surgical resection |
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|
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Tumor stage |
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Radiation Therapy
- Radiotherapy is the mainstay of treatment for medulloblastoma.[2]
- Radiotherapy for medulloblastoma must be started within 6 weeks following surgery.
- The main radiotherapy techniques used in the management of medulloblastoma patients include:
- Conventional radiotherapy technique
- Intensity modulated radiotherapy technique
- Three dimensional radiotherapy technique
- Three dimensional radiotherapy technique demonstrated better outcomes when compared to conventional and intensity modulated radiotherapy techniques.
- As medulloblastoma tends to spread along the cerebrospinal fluid, it is recommended to deliver a craniospinal irradiation with a boost to the posterior fossa.
Chemotherapy
References
- ↑ von Hoff K, Rutkowski S (2012). "Medulloblastoma". Curr Treat Options Neurol. 14 (4): 416–26. doi:10.1007/s11940-012-0183-8. PMID 22622599.
- ↑ 2.0 2.1 Bartlett F, Kortmann R, Saran F (2013). "Medulloblastoma". Clin Oncol (R Coll Radiol). 25 (1): 36–45. doi:10.1016/j.clon.2012.09.008. PMID 23245832.
- ↑ Medulloblastoma staging. Wikibooks(2015) https://en.wikibooks.org/wiki/Radiation_Oncology/Medulloblastoma/Staging Accessed on September, 28th 2015)