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{{CMG}}; {{AE}} {{AS}}
{{CMG}}; {{AE}} {{AS}}
==Overview==
==Overview==
Non-Hodgkin lymphoma may be classified into subtypes according to updated [[WHO]] classification and based on rate of growth.
Non-Hodgkin lymphoma may be classified into subtypes according to updated [[WHO]] classification and rate of growth.
==Classification of Non-Hodgkin lymphoma==
==Classification==
===A. Updated WHO classification===
===A. Updated WHO classification===
* Non-Hodgkin lymphoma may be classified according to updated [[WHO]] classification into 2 groups:<ref name=”cancer gov”>National Cancer Institute. Physician Data Query Database 2015.http://www.cancer.gov/publications/pdq</ref>
* Non-Hodgkin lymphoma may be classified according to updated [[WHO]] classification into 2 groups:<ref name=”cancer gov”>National Cancer Institute. Physician Data Query Database 2015.http://www.cancer.gov/publications/pdq</ref>
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| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | [[T-cell granular lymphocytic leukemia]]
| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | [[T-cell granular lymphocytic leukemia]]
|-
|-
| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | [[Lympho plasmacytic lymphoma]] / immunocytoma
| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | Lymphoplasmacytic lymphoma / immunocytoma
| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | [[Mycosis fungoides]] / [[Sézary syndrome]]
| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | [[Mycosis fungoides]] / [[Sézary syndrome]]
|-
|-
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| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | Hepatosplenic gamma / delta T-cell lymphoma
| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | Hepatosplenic gamma / delta T-cell lymphoma
|-
|-
| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | Extra nodal marginal zone B-cell lymphoma of mucosa-associated lymphatic tissue (MALT) type
| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphatic tissue (MALT) type
| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | [[Subcutaneous panniculitis-like T-cell lymphoma]]
| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | [[Subcutaneous panniculitis-like T-cell lymphoma]]
|-
|-
| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | [[Nodal marginal zone B-cell lymphoma]] (± mono cytoid B-cells)
| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | [[Nodal marginal zone B-cell lymphoma]] (± monocytoid B-cells)
| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | Angio immunoblastic T-cell lymphoma
| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | Angioimmunoblastic T-cell lymphoma
|-
|-
| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | [[Splenic marginal zone lymphoma]] (± villous lymphocytes)
| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | [[Splenic marginal zone lymphoma]] (± villous lymphocytes)

Revision as of 17:57, 2 October 2015

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]

Overview

Non-Hodgkin lymphoma may be classified into subtypes according to updated WHO classification and rate of growth.

Classification

A. Updated WHO classification

  • Non-Hodgkin lymphoma may be classified according to updated WHO classification into 2 groups:[1]
  • B-cell neoplasms
  • T-cell and putative NK-cell neoplasms
Updated WHO classification of Non-Hodgkin lymphoma
B-cell neoplasms T-cell and putative NK-cell neoplasms
Precursor B-cell neoplasm Precursor T-cell neoplasm
Precursor B-acute lymphoblastic leukemia / lymphoblastic lymphoma (LBL) Precursor T-acute lymphoblastic leukemia / lymphoblastic lymphoma (LBL)
Peripheral B-cell neoplasms Peripheral T-cell and NK-cell neoplasms
B-cell CLL / small lymphocytic lymphoma T-cell CLL / prolymphocytic leukemia
B-cell prolymphocytic leukemia T-cell granular lymphocytic leukemia
Lymphoplasmacytic lymphoma / immunocytoma Mycosis fungoides / Sézary syndrome
Mantle cell lymphoma Peripheral T-cell lymphoma, not otherwise characterized
Follicular lymphoma Hepatosplenic gamma / delta T-cell lymphoma
Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphatic tissue (MALT) type Subcutaneous panniculitis-like T-cell lymphoma
Nodal marginal zone B-cell lymphoma (± monocytoid B-cells) Angioimmunoblastic T-cell lymphoma
Splenic marginal zone lymphoma (± villous lymphocytes) Extranodal T-/NK-cell lymphoma, nasal type
Hairy cell leukemia Enteropathy-type intestinal T-cell lymphoma
Plasmacytoma / plasma cell myeloma Adult T-cell lymphoma / leukemia (human T-lymphotrophic virus [HTLV] 1+)
Diffuse large B-cell lymphoma Anaplastic large cell lymphoma, primary systemic type
Burkitt lymphoma Anaplastic large cell lymphoma, primary cutaneous type
Aggressive NK-cell leukemia

B. Classification based on rate of growth

  • Non-Hodgkin lymphoma may be classified based on rate of growth into 2 Groups:[2]
  • Low-grade or Indolent lymphoma
  • High-grade or Aggressive lymphoma
Non-Hodgkin lymphoma classification
Grade Description
Low-grade or Indolent lymphoma
  • Tend to grow very slowly, tend to widespread by the time they are diagnosed, often involving the bone marrow and spleen
  • Often treated only when symptoms appear
  • Can shrink or seem to disappear with treatment, but they tend to come back
  • Can change into more aggressive lymphomas
  • Have a fairly good prognosis
High-grade or Aggressive lymphoma
  • Grow quickly and tend to spread to lymph nodes or other organs throughout the body
  • Cause symptoms and need treatment right away
  • Can frequently be successfully treated with intensive chemotherapy treatment

References

  1. ↑ National Cancer Institute. Physician Data Query Database 2015.http://www.cancer.gov/publications/pdq
  2. ↑ "Canadian Cancer Society Grades of non-Hodgkin lymphoma".

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