Ewing's sarcoma epidemiology and demographics: Difference between revisions
No edit summary |
|||
Line 5: | Line 5: | ||
===Incidence=== | ===Incidence=== | ||
*The incidence of Ewing sarcoma has remained unchanged for 30 years. | *The incidence of Ewing sarcoma has remained unchanged for 30 years. | ||
*The incidence | *The overall incidence of Ewing sarcoma is 0.1 cases for 100,000 individuals. | ||
* | *The overall incidence of Ewing sarcoma in children aged 10 to 19 years is 1 case for 100,000 individuals. | ||
* | *The median age of patients with Ewing sarcoma is 15 years, and more than 50% of patients are adolescents. Well-characterized cases of Ewing sarcoma in neonates and infants have been described. | ||
===Race=== | |||
*Incidence of Ewing sarcoma in the United States is nine times greater in whites than in African Americans, with an intermediate incidence in Asians. | |||
*The relative paucity of Ewing sarcoma in people of African or Asian descent may be explained, in part, by a specific polymorphism. | *The relative paucity of Ewing sarcoma in people of African or Asian descent may be explained, in part, by a specific polymorphism. | ||
*The polymorphism associated with the increased risk is found at a much higher frequency in whites than in blacks or Asians, possibly explaining the epidemiology of the relative infrequency of Ewing sarcoma in the latter populations. | *The polymorphism associated with the increased risk is found at a much higher frequency in whites than in blacks or Asians, possibly explaining the epidemiology of the relative infrequency of Ewing sarcoma in the latter populations. | ||
===Prevalence=== | ===Prevalence=== | ||
The frequency in the United States depends on the patient's age, with a rate of 0.3 case per 1,000,000 children in those younger than 3 years of age to as high as 4.6 cases per 1,000,000 in adolescents aged 15-19 years. Internationally the annual incidence rate averages less than 2 cases per 1,000,000 children. In the United Kingdom an average of six children per year are diagnosed, mainly males in early stages of puberty. | The frequency in the United States depends on the patient's age, with a rate of 0.3 case per 1,000,000 children in those younger than 3 years of age to as high as 4.6 cases per 1,000,000 in adolescents aged 15-19 years. Internationally the annual incidence rate averages less than 2 cases per 1,000,000 children. In the United Kingdom an average of six children per year are diagnosed, mainly males in early stages of puberty. |
Revision as of 15:48, 5 October 2015
Ewing's sarcoma Microchapters |
Diagnosis |
---|
Treatment |
Case Studies |
Ewing's sarcoma epidemiology and demographics On the Web |
American Roentgen Ray Society Images of Ewing's sarcoma epidemiology and demographics |
Risk calculators and risk factors for Ewing's sarcoma epidemiology and demographics |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Assistant Editor(s)-In-Chief: Michael Maddaleni, B.S.
Epidemiology and Demographics
Incidence
- The incidence of Ewing sarcoma has remained unchanged for 30 years.
- The overall incidence of Ewing sarcoma is 0.1 cases for 100,000 individuals.
- The overall incidence of Ewing sarcoma in children aged 10 to 19 years is 1 case for 100,000 individuals.
- The median age of patients with Ewing sarcoma is 15 years, and more than 50% of patients are adolescents. Well-characterized cases of Ewing sarcoma in neonates and infants have been described.
Race
- Incidence of Ewing sarcoma in the United States is nine times greater in whites than in African Americans, with an intermediate incidence in Asians.
- The relative paucity of Ewing sarcoma in people of African or Asian descent may be explained, in part, by a specific polymorphism.
- The polymorphism associated with the increased risk is found at a much higher frequency in whites than in blacks or Asians, possibly explaining the epidemiology of the relative infrequency of Ewing sarcoma in the latter populations.
Prevalence
The frequency in the United States depends on the patient's age, with a rate of 0.3 case per 1,000,000 children in those younger than 3 years of age to as high as 4.6 cases per 1,000,000 in adolescents aged 15-19 years. Internationally the annual incidence rate averages less than 2 cases per 1,000,000 children. In the United Kingdom an average of six children per year are diagnosed, mainly males in early stages of puberty. Ewing's sarcoma is the second most frequent bone sarcoma in patients younger than 20. The most frequent is osteosarcoma.[1] There are approximately 225 new diagnoses of Ewing's sarcoma in North America/year. [1]
Age
Due to the prevalence of diagnosis during teenage years, there may possibly be a link between the onset of puberty and the early stages of this disease, although no research is currently being conducted to confirm this theory. Ewing's sarcoma occurs most frequently in male teenagers. Typically occurs in children and adolescents between 10 and 20 years of age (95% between 4 and 25 years of age), and has a slight male predilection (M:F 1.5:1) 1-2. It's rare in black people.
Gender
Ewing's sarcoma is more common in males and usually presents in childhood or early adulthood, with a peak between 10 and 20 years of age.
Race
Caucasians more frequently develop Ewing's sarcoma than Asians. Also, African Americans and Africans rarely suffer from this disease. There was a study done between 1973 and 1985, and out of 650 cases only three of them were from African descent.[1]
References
- ↑ 1.0 1.1 1.2 Iwamoto Y (2007). "Diagnosis and treatment of Ewing's sarcoma". Japanese Journal of Clinical Oncology. 37 (2): 79–89. doi:10.1093/jjco/hyl142. PMID 17272319. Retrieved 2011-12-21. Unknown parameter
|month=
ignored (help)