Zollinger-Ellison syndrome natural history, complications and prognosis: Difference between revisions
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==Prognosis== | ==Prognosis== | ||
The prognosis of Zollinger-Ellison syndrome is good with treatment. Without treatment, Zollinger-Ellison syndrome may result in [[weight loss]], [[anemia]], and death.<ref name="pmid7903006">{{cite journal| author=Melvin WS, Johnson JA, Sparks J, Innes JT, Ellison EC| title=Long-term prognosis of Zollinger-Ellison syndrome in multiple endocrine neoplasia. | journal=Surgery | year= 1993 | volume= 114 | issue= 6 | pages= 1183-8 | pmid=7903006 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7903006 }} </ref> | The prognosis of Zollinger-Ellison syndrome is good with treatment and the 5 and 10-year survival rate of patients with Zollinger-Ellison syndrome is approximately 94% and 75%, respectively. Without treatment, Zollinger-Ellison syndrome may result in [[weight loss]], [[anemia]], and death.<ref name="pmid7903006">{{cite journal| author=Melvin WS, Johnson JA, Sparks J, Innes JT, Ellison EC| title=Long-term prognosis of Zollinger-Ellison syndrome in multiple endocrine neoplasia. | journal=Surgery | year= 1993 | volume= 114 | issue= 6 | pages= 1183-8 | pmid=7903006 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7903006 }} </ref> | ||
==References== | ==References== |
Revision as of 15:38, 13 October 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2]
Overview
If left untreated, patients with Zollinger-Ellison syndrome may progress to develop abdominal pain, diarrhea, and heartburn.[1] Common complications of Zollinger-Ellison syndrome include upper gastrointestinal bleeding, anemia, and duodenal ulcer perforation. Prognosis is generally good, and the 5 and 10-year survival rate of patients with Zollinger-Ellison syndrome is approximately 94% and 75%, respectively.[2]
Natural History
- If left untreated, patients with Zollinger-Ellison syndrome may progress to develop abdominal pain, diarrhea, and heartburn.[1]
- The symptoms of Zollinger-Ellison syndrome usually develop in the third decade of life. Without treatment, the patient will develop symptoms of gastrinoma, which may eventually lead to anemia and death.[3]
Complications
Common complications associated with Zollinger-Ellison syndrome include:
Prognosis
The prognosis of Zollinger-Ellison syndrome is good with treatment and the 5 and 10-year survival rate of patients with Zollinger-Ellison syndrome is approximately 94% and 75%, respectively. Without treatment, Zollinger-Ellison syndrome may result in weight loss, anemia, and death.[2]
References
- ↑ 1.0 1.1 Roy PK, Venzon DJ, Shojamanesh H, Abou-Saif A, Peghini P, Doppman JL; et al. (2000). "Zollinger-Ellison syndrome. Clinical presentation in 261 patients". Medicine (Baltimore). 79 (6): 379–411. PMID 11144036.
- ↑ 2.0 2.1 Melvin WS, Johnson JA, Sparks J, Innes JT, Ellison EC (1993). "Long-term prognosis of Zollinger-Ellison syndrome in multiple endocrine neoplasia". Surgery. 114 (6): 1183–8. PMID 7903006.
- ↑ Riegert-Johnson D, Gleeson FC, Westra W, et al. Peutz-Jeghers Syndrome. 2008 Jul 18 [Updated 2008 Aug 9]. In: Riegert-Johnson DL, Boardman LA, Hefferon T, et al., editors. Cancer Syndromes [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2009-. Available from: http://www.ncbi.nlm.nih.gov/books/NBK1826/