Ewing's sarcoma epidemiology and demographics: Difference between revisions
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{{CMG}}; '''Assistant Editor(s)-In-Chief:''' [[User:Michael Maddaleni|Michael Maddaleni, B.S.]] | {{CMG}}; '''Assistant Editor(s)-In-Chief:''' [[User:Michael Maddaleni|Michael Maddaleni, B.S.]] | ||
==Epidemiology and Demographics== | ==Epidemiology and Demographics== | ||
Ewing sarcoma is the second most common malignant bone tumor in patients younger than 20. The most frequent is [[osteosarcoma]].<ref name="pmid17272319">{{cite journal |author=Iwamoto Y |title=Diagnosis and treatment of Ewing's sarcoma |journal=[[Japanese Journal of Clinical Oncology]] |volume=37 |issue=2 |pages=79–89 |year=2007 |month=February |pmid=17272319 |doi=10.1093/jjco/hyl142 |url=http://jjco.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=17272319 |accessdate=2011-12-21}}</ref> | |||
===Incidence=== | ===Incidence=== | ||
*The incidence of Ewing sarcoma has remained unchanged for 30 years. | *The incidence of Ewing sarcoma has remained unchanged for 30 years. | ||
*The overall incidence of Ewing sarcoma is 0.1 cases for 100,000 individuals. | *The overall incidence of Ewing sarcoma is 0.1 cases for 100,000 individuals. | ||
*The | *The incidence of Ewing sarcoma in children aged 10 to 19 years is 1 case for 100,000 individuals. | ||
===Race=== | ===Race=== | ||
*Incidence of Ewing sarcoma in the United States is nine times greater in whites than in African Americans, with an intermediate incidence in Asians. | *Incidence of Ewing sarcoma in the United States is nine times greater in whites than in African Americans, with an intermediate incidence in Asians. | ||
*The relative paucity of Ewing sarcoma in people of African or Asian descent may be explained, in part, by a specific polymorphism. | *The relative paucity of Ewing sarcoma in people of African or Asian descent may be explained, in part, by a specific polymorphism. | ||
*The polymorphism associated with the increased risk is found at a much higher frequency in whites than in blacks or Asians, possibly explaining the epidemiology of the relative infrequency of Ewing sarcoma in the latter populations. | *The polymorphism associated with the increased risk is found at a much higher frequency in whites than in blacks or Asians, possibly explaining the epidemiology of the relative infrequency of Ewing sarcoma in the latter populations. | ||
*Caucasians more frequently develop Ewing's sarcoma than Asians. Also, African Americans and Africans rarely suffer from this disease. There was a study done between 1973 and 1985, and out of 650 cases only three of them were from African descent.<ref name="pmid17272319">{{cite journal |author=Iwamoto Y |title=Diagnosis and treatment of Ewing's sarcoma |journal=[[Japanese Journal of Clinical Oncology]] |volume=37 |issue=2 |pages=79–89 |year=2007 |month=February |pmid=17272319 |doi=10.1093/jjco/hyl142 |url=http://jjco.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=17272319 |accessdate=2011-12-21}}</ref> | |||
===Age=== | ===Age=== | ||
* | *Ewing sarcoma typically occurs in children and adolescents between 10 and 20 years of age (95% between 4 and 25 years of age). | ||
*The median age of patients with Ewing sarcoma is 15 years. | |||
*Well-characterized cases of Ewing sarcoma in neonates and infants have been described. | |||
===Gender=== | ===Gender=== | ||
Ewing's sarcoma is more common in males and usually presents in childhood or early adulthood, with a peak between 10 and 20 years of age. | Ewing's sarcoma is more common in males and usually presents in childhood or early adulthood, with a peak between 10 and 20 years of age. | ||
==References== | ==References== |
Revision as of 17:18, 5 October 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Assistant Editor(s)-In-Chief: Michael Maddaleni, B.S.
Epidemiology and Demographics
Ewing sarcoma is the second most common malignant bone tumor in patients younger than 20. The most frequent is osteosarcoma.[1]
Incidence
- The incidence of Ewing sarcoma has remained unchanged for 30 years.
- The overall incidence of Ewing sarcoma is 0.1 cases for 100,000 individuals.
- The incidence of Ewing sarcoma in children aged 10 to 19 years is 1 case for 100,000 individuals.
Race
- Incidence of Ewing sarcoma in the United States is nine times greater in whites than in African Americans, with an intermediate incidence in Asians.
- The relative paucity of Ewing sarcoma in people of African or Asian descent may be explained, in part, by a specific polymorphism.
- The polymorphism associated with the increased risk is found at a much higher frequency in whites than in blacks or Asians, possibly explaining the epidemiology of the relative infrequency of Ewing sarcoma in the latter populations.
- Caucasians more frequently develop Ewing's sarcoma than Asians. Also, African Americans and Africans rarely suffer from this disease. There was a study done between 1973 and 1985, and out of 650 cases only three of them were from African descent.[1]
Age
- Ewing sarcoma typically occurs in children and adolescents between 10 and 20 years of age (95% between 4 and 25 years of age).
- The median age of patients with Ewing sarcoma is 15 years.
- Well-characterized cases of Ewing sarcoma in neonates and infants have been described.
Gender
Ewing's sarcoma is more common in males and usually presents in childhood or early adulthood, with a peak between 10 and 20 years of age.
References
- ↑ 1.0 1.1 Iwamoto Y (2007). "Diagnosis and treatment of Ewing's sarcoma". Japanese Journal of Clinical Oncology. 37 (2): 79–89. doi:10.1093/jjco/hyl142. PMID 17272319. Retrieved 2011-12-21. Unknown parameter
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