Burkitt's lymphoma medical therapy: Difference between revisions
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The predominant therapy for Burkitt's lymphoma is chemotherapy. Adjunctive [[immunotherapy]] and [[stem cell transplantation]] may be required.<ref Name= Cancer.ca>Burkitt lymphoma. Canadian Cancer Society. http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/burkitt-lymphoma/?region=on Accessed on September 28, 2015</ref> | The predominant therapy for Burkitt's lymphoma is chemotherapy. Adjunctive [[immunotherapy]] and [[stem cell transplantation]] may be required.<ref Name= Cancer.ca>Burkitt lymphoma. Canadian Cancer Society. http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/burkitt-lymphoma/?region=on Accessed on September 28, 2015</ref> | ||
===Chemotherapy=== | ===Chemotherapy=== | ||
* | * Chemotherapeutic regimens for Burkitt's lymphoma include: | ||
* | * [[Cyclophosphamide]] {{and}} [[Vincristine]] {{and}} [[Doxorubicin]] {{and}} [[Methotrexate]] (CODOX-M) | ||
* | * [[Ifosfamide]] {{plus}} [[Mesna]] {{and}} [[Etoposide]] {{and}} [[Cytarabine]] (IVAC) | ||
* [[Cyclophosphamide]] {{and}} [[Vincristine]] {{and}} [[Doxorubicin]] {{and}} [[Dexamethasone]] {{and}} [[Methotrexate]] {{and}} [[Cytarabine]] (Hyper-CVAD) | |||
'''CNS prophylaxis''' | '''CNS prophylaxis''' | ||
* There is a high risk that Burkitt's lymphoma will spread to the central nervous system ([[CNS]]) | * There is a high risk that Burkitt's lymphoma will spread to the central nervous system ([[CNS]]) | ||
* CNS prophylaxis may involve giving [[intrathecal]] chemotherapy high doses of systemic therapy, or both methods may be used | * CNS prophylaxis may involve giving [[intrathecal]] chemotherapy, high doses of systemic therapy, or both methods may be used | ||
* [[Methotrexate]] and [[Cytarabine]] are the drugs used most often for CNS prophylaxis | * [[Methotrexate]] and [[Cytarabine]] are the drugs used most often for CNS prophylaxis | ||
===Biological therapy=== | ===Biological therapy=== | ||
* [[Monoclonal antibodies]] are a type of biological therapy that is effective in treating Burkitt's lymphoma | * [[Monoclonal antibodies]] are a type of biological therapy that is effective in treating Burkitt's lymphoma | ||
Revision as of 17:07, 8 October 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]
Overview
The predominant therapy for Burkitt's lymphoma is chemotherapy. Adjunctive immunotherapy and stem cell transplantation may be required.
Medical Therapy
The predominant therapy for Burkitt's lymphoma is chemotherapy. Adjunctive immunotherapy and stem cell transplantation may be required.[1]
Chemotherapy
- Chemotherapeutic regimens for Burkitt's lymphoma include:
- Cyclophosphamide AND Vincristine AND Doxorubicin AND Methotrexate (CODOX-M)
- Ifosfamide PLUS Mesna AND Etoposide AND Cytarabine (IVAC)
- Cyclophosphamide AND Vincristine AND Doxorubicin AND Dexamethasone AND Methotrexate AND Cytarabine (Hyper-CVAD)
CNS prophylaxis
- There is a high risk that Burkitt's lymphoma will spread to the central nervous system (CNS)
- CNS prophylaxis may involve giving intrathecal chemotherapy, high doses of systemic therapy, or both methods may be used
- Methotrexate and Cytarabine are the drugs used most often for CNS prophylaxis
Biological therapy
- Monoclonal antibodies are a type of biological therapy that is effective in treating Burkitt's lymphoma
- Rituximab may be added to each of the above chemotherapy regimens
Stem cell transplant
- A stem cell transplant may be offered to some people with Burkitt's lymphoma if their lymphoma returns or relapses after treatment
References
- ↑ Burkitt lymphoma. Canadian Cancer Society. http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/burkitt-lymphoma/?region=on Accessed on September 28, 2015