Anaplastic large cell lymphoma classification: Difference between revisions

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Revision as of 17:42, 8 October 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]

Overview

Anaplastic large cell lymphoma may be classified into 2 subtypes: anaplastic large cell lymphoma, ALK positive and anaplastic large cell lymphoma, ALK negative. Based on clinical presentations, anaplastic large cell lymphoma may be classified into either primary cutaneous anaplastic large cell lymphoma and primary systemic anaplastic large cell lymphoma.

Classification

Anaplastic large cell lymphoma (peripheral T-cell lymphoma Non-Hodgkin Lymphoma) may be classified into 2 subtypes:

Based on clinical presentations, anaplastic large cell lymphoma may be classified into either^[1]

Primary cutaneous anaplastic large cell lymphoma
Primary systemic anaplastic large cell lymphoma

Based on morphology,anaplastic large cell lymphoma may be classified into 3 subtypes:

Classical Variants

Atypical Variants

Rare Variants

**Classification based on the clinical presentation**^[1]
Name	Description
Primary cutaneous anaplastic large cell lymphoma	Confined to the skin Usually have a single lump or tumor in the skin May also spread to lymph nodes in the area Associated with a rare skin condition called lymphomatoid papulosis Less aggressive than primary systemic anaplastic large cell lymphoma Occasionally individuals have a spontaneous remission Have a fairly good prognosis
Primary systemic anaplastic large cell lymphoma	Usually involves the lymph nodes Can also occur in organs or tissues other than the lymph nodes (extranodal sites), including: lungs, liver, bone marrow, bone, gastrointestinal tract, skin and soft tissue Most individuals have advanced stage (stage III or IV) disease when they are diagnosed Usually a fast-growing (aggressive) lymphoma

**Morphologic Classification** ^[2]
Name	Description
Classical Variants
Common pattern	ALK positive anaplastic large cell lymphoma
Atypical Variants
Small cell	ALK positive anaplastic large cell lymphoma
Lymphohistiocytic	ALK positive anaplastic large cell lymphoma
Giant cell	ALK positive anaplastic large cell lymphoma
Hodgkin's like	ALK positive anaplastic large cell lymphoma
Rare Variants
Sarcomatoid	ALK positive anaplastic large cell lymphoma

References

↑ ^1.0 ^1.1 Anaplastic large cell lymphoma. Canadian Cancer Society. http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/anaplastic-large-cell-lymphoma/?region=on Accessed on October 7, 2015
↑ The anaplastic lymphoma kinase in the pathogenesis of cancer. http://go.galegroup.com/ps/retrieve.dosgHitCountType=None&sort=RELEVANCE&inPS=true&prodId=HRCA&userGroupName=mlin_b_bethidmc&tabID=T002&searchId=R1&resultListType=RESULT_LIST&contentSegment=&searchType=AdvancedSearchForm&currentPosition=1&contentSet=GALE%7CA188154738&&docId=GALE Accessed on October 8, 2015

Template:WH Template:WS

[canadian.cancer-1] 1.0 ^1.1 Anaplastic large cell lymphoma. Canadian Cancer Society. http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/anaplastic-large-cell-lymphoma/?region=on Accessed on October 7, 2015

[2] The anaplastic lymphoma kinase in the pathogenesis of cancer. http://go.galegroup.com/ps/retrieve.dosgHitCountType=None&sort=RELEVANCE&inPS=true&prodId=HRCA&userGroupName=mlin_b_bethidmc&tabID=T002&searchId=R1&resultListType=RESULT_LIST&contentSegment=&searchType=AdvancedSearchForm&currentPosition=1&contentSet=GALE%7CA188154738&&docId=GALE Accessed on October 8, 2015

[1]

[2]

@@ Line 11: / Line 11: @@
 :* Primary cutaneous anaplastic large cell lymphoma
 :* Primary systemic anaplastic large cell lymphoma
+* Based on morphology,anaplastic large cell lymphoma may be classified into 3 subtypes:
+:* Classical Variants
+:* Atypical Variants
+:* Rare Variants
+{| style="border: 0px; font-size: 90%; margin: 3px;" align=center
+|+ '''Classification based on the clinical presentation'''<ref name= canadian.cancer>Anaplastic large cell lymphoma. Canadian Cancer Society. http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/anaplastic-large-cell-lymphoma/?region=on Accessed on October 7, 2015</ref>
+! style="background: #4479BA;; color:#FFF;" | Name
+! style="background: #4479BA;; color:#FFF;" | Description
+|-
+| style="text-align: center; padding: 5px 5px; background: #F5F5F5;" |  Primary cutaneous anaplastic large cell lymphoma
+| style="padding: 5px 5px; background: #F5F5F5;" |
+* Confined to the skin
+* Usually have a single lump or tumor in the skin
+* May also spread to lymph nodes in the area
+* Associated with a rare skin condition called [[lymphomatoid papulosis]]
+* Less aggressive than primary systemic anaplastic large cell lymphoma
+* Occasionally individuals have a spontaneous remission
+* Have a fairly good prognosis
+|-
+| style="text-align: center; padding: 5px 5px; background: #F5F5F5;" |  Primary systemic anaplastic large cell lymphoma
+| style="padding: 5px 5px; background: #F5F5F5;" |
+* Usually involves the lymph nodes
+* Can also occur in organs or tissues other than the lymph nodes (extranodal sites), including:
+:* lungs, liver, bone marrow, bone, gastrointestinal tract, skin and soft tissue
+* Most individuals have advanced stage (stage III or IV) disease when they are diagnosed
+* Usually a fast-growing (aggressive) lymphoma
+|}
 {| style="border: 0px; font-size: 90%; margin: 3px;" align=center
@@ Line 19: / Line 49: @@
 | style="padding: 5px 5px; background: #DCDCDC;" colspan=2 | '''Classical Variants'''
 |-
-| style="text-align: center; padding: 5px 5px; background: #F5F5F5;" |  '''Common pattern'''
+| style="text-align: center; padding: 5px 5px; background: #F5F5F5;" |  Common pattern
 | style="padding: 5px 5px; background: #F5F5F5;" |
 * ALK positive anaplastic large cell lymphoma
@@ Line 25: / Line 55: @@
 | style="padding: 5px 5px; background: #DCDCDC;" colspan=6 | '''Atypical Variants'''
 |-
-| style="text-align: center; padding: 5px 5px; background: #F5F5F5;" |  '''Small cell'''
+| style="text-align: center; padding: 5px 5px; background: #F5F5F5;" |  Small cell
 | style="padding: 5px 5px; background: #F5F5F5;" |
 * ALK positive anaplastic large cell lymphoma
 |-
-| style="text-align: center; padding: 5px 5px; background: #F5F5F5;" |  '''Lymphohistiocytic'''
+| style="text-align: center; padding: 5px 5px; background: #F5F5F5;" |  Lymphohistiocytic
 | style="padding: 5px 5px; background: #F5F5F5;" |
 * ALK positive anaplastic large cell lymphoma
 |-
+| style="text-align: center; padding: 5px 5px; background: #F5F5F5;" |  Giant cell
-| style="text-align: center; padding: 5px 5px; background: #F5F5F5;" |  '''Giant cell'''
 | style="padding: 5px 5px; background: #F5F5F5;" |
 * ALK positive anaplastic large cell lymphoma
 |-
-| style="text-align: center; padding: 5px 5px; background: #F5F5F5;" |  '''Hodgkin's like'''
+| style="text-align: center; padding: 5px 5px; background: #F5F5F5;" |  Hodgkin's like
 | style="padding: 5px 5px; background: #F5F5F5;" |
 * ALK positive anaplastic large cell lymphoma
@@ Line 44: / Line 73: @@
 | style="padding: 5px 5px; background: #DCDCDC;" colspan=6 | '''Rare Variants'''
 |-
-| style="text-align: center; padding: 5px 5px; background: #F5F5F5;" |  '''Sarcomatoid'''
+| style="text-align: center; padding: 5px 5px; background: #F5F5F5;" |  Sarcomatoid
 | style="padding: 5px 5px; background: #F5F5F5;" |
 * ALK positive anaplastic large cell lymphoma
 |}
-{| style="border: 0px; font-size: 90%; margin: 3px;" align=center
-|+ '''Classification based on the clinical presentation'''<ref name= canadian.cancer>Anaplastic large cell lymphoma. Canadian Cancer Society. http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/anaplastic-large-cell-lymphoma/?region=on Accessed on October 7, 2015</ref>
-! style="background: #4479BA;; color:#FFF;" | Name
-! style="background: #4479BA;; color:#FFF;" | Description
-|-
-| style="text-align: center; padding: 5px 5px; background: #F5F5F5;" |  Primary cutaneous anaplastic large cell lymphoma
-| style="padding: 5px 5px; background: #F5F5F5;" |
-* Confined to the skin
-* Usually have a single lump or tumor in the skin
-* May also spread to lymph nodes in the area
-* Associated with a rare skin condition called [[lymphomatoid papulosis]]
-* Less aggressive than primary systemic anaplastic large cell lymphoma
-* Occasionally individuals have a spontaneous remission
-* Have a fairly good prognosis
-|-
-| style="text-align: center; padding: 5px 5px; background: #F5F5F5;" |  Primary systemic anaplastic large cell lymphoma
-| style="padding: 5px 5px; background: #F5F5F5;" |
-* Usually involves the lymph nodes
-* Can also occur in organs or tissues other than the lymph nodes (extranodal sites), including:
-:* lungs, liver, bone marrow, bone, gastrointestinal tract, skin and soft tissue
-* Most individuals have advanced stage (stage III or IV) disease when they are diagnosed
-* Usually a fast-growing (aggressive) lymphoma
-|}
 ==References==
 {{Reflist|2}}

Anaplastic large cell lymphoma classification: Difference between revisions

Revision as of 17:42, 8 October 2015

Overview

Classification

References

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