Ependymoma risk factors: Difference between revisions
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{{CMG}} {{AE}} {{AAM}} | {{CMG}} {{AE}} {{AAM}} | ||
==Overview== | ==Overview== | ||
Common risk factors in the development of ependymoma are | Common risk factors in the development of ependymoma are certain hereditary diseases ([[neurofibromatosis]] type II and Turcot syndrome), ''ERBB2'', ''ERBB4'', and human telomerase reverse transcriptase ''TERT'' gene expression, over-expression of [[kinetochore]] proteins, and down-regulation of [[metallothionein|metallothioneins]]. | ||
==Risk Factors== | ==Risk Factors== | ||
* Children with certain hereditary diseases, such as [[neurofibromatosis type II]] (NF2), [[Turcot syndrome]] B, and [[MEN1 syndrome]], have been found to be more frequently afflicted with ependymal tumors | * Children with certain hereditary diseases, such as [[neurofibromatosis type II]] (NF2), [[Turcot syndrome]] B, and [[MEN1 syndrome]], have been found to be more frequently afflicted with ependymal tumors | ||
Revision as of 18:47, 15 October 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ahmad Al Maradni, M.D. [2]
Overview
Common risk factors in the development of ependymoma are certain hereditary diseases (neurofibromatosis type II and Turcot syndrome), ERBB2, ERBB4, and human telomerase reverse transcriptase TERT gene expression, over-expression of kinetochore proteins, and down-regulation of metallothioneins.
Risk Factors
- Children with certain hereditary diseases, such as neurofibromatosis type II (NF2), Turcot syndrome B, and MEN1 syndrome, have been found to be more frequently afflicted with ependymal tumors
- increased occurrence of chromosome 1q and proteins such as tenascin C and epidermal growth factor is associated with increased risk for developing ependymal tumors.
- ERBB2, ERBB4, and human telomerase reverse transcriptase TERT gene expression promote tumor cell proliferation, contributing to aggressive tumor behavior.[1]
- High expression of epidermal growth factor receptor EGFR correlates with unfavorable outcome.[2]
- Over-expression of kinetochore proteins and down-regulation of metallothioneins are associated with recurrence in ependymomas.[3]
References
- ↑ Ependymoma https://en.wikipedia.org/wiki/Pediatric_ependymoma#Cell_of_origin. URL Accessed on 10 08 2015
- ↑ Mendrzyk F, Korshunov A, Benner A, Toedt G, Pfister S, Radlwimmer B; et al. (2006). "Identification of gains on 1q and epidermal growth factor receptor overexpression as independent prognostic markers in intracranial ependymoma". Clin Cancer Res. 12 (7 Pt 1): 2070–9. doi:10.1158/1078-0432.CCR-05-2363. PMID 16609018.
- ↑ Peyre M, Commo F, Dantas-Barbosa C, Andreiuolo F, Puget S, Lacroix L; et al. (2010). "Portrait of ependymoma recurrence in children: biomarkers of tumor progression identified by dual-color microarray-based gene expression analysis". PLoS One. 5 (9): e12932. doi:10.1371/journal.pone.0012932. PMC 2945762. PMID 20885975.