Gestational trophoblastic neoplasia laboratory findings: Difference between revisions
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* Human placental lactogen (hPL) is a tumour marker that may be used to follow women with placental site trophoblastic tumours. High hPL levels are found in women with some types of GTD. | * Human placental lactogen (hPL) is a tumour marker that may be used to follow women with placental site trophoblastic tumours. High hPL levels are found in women with some types of GTD. | ||
:* [[Complete blood count]]- A CBC can check for anemia from long-term (chronic) vaginal bleeding. | :* [[Complete blood count]]- A CBC can check for anemia from long-term (chronic) vaginal bleeding. | ||
Karyotyping | ===Karyotyping=== | ||
Hydatidiform moles (molar pregnancies) result from abnormal fertilization of an egg by 1 or more sperm, which may result in an abnormal number of chromosomes. | Hydatidiform moles (molar pregnancies) result from abnormal fertilization of an egg by 1 or more sperm, which may result in an abnormal number of chromosomes. | ||
===Flow cytometry=== | |||
Flow cytometry | |||
Flow cytometry helps determine the types of cells that are present. It also shows if there are an abnormal number of chromosomes, such as in hydatidiform moles. | Flow cytometry helps determine the types of cells that are present. It also shows if there are an abnormal number of chromosomes, such as in hydatidiform moles. | ||
===Immunohistochemistry=== | |||
Immunohistochemistry | Immunohistochemistry helps determine the types of cells that are present, which can be helpful in identifying hydatidiform moles. | ||
:* Kidney function tests | :* Kidney function tests | ||
:*[[Liver function tests]] | :*[[Liver function tests]] |
Revision as of 15:16, 13 October 2015
Overview
Increased quantitative beta HCG levels.
Laboratory Findings
Blood tests that may be done include:
Quantitative serum HCG
- Human chorionic gonadotropin (HCG or b-HCG) is the most common tumour marker test used to diagnose GTD.
- HCG is a hormone that the placenta normally produces during pregnancy.
- HCG is a very sensitive test for diagnosing most gestational trophoblastic tumours. HCG is usually measured in the blood, but it can also be measured in the urine.
- HCG levels are much higher in women with complete hydatidiform moles and gestational choriocarcinoma compared to HCG levels in women with a normal pregnancy.
- With partial moles, the HCG level is higher than normal, but it is not as high as with other types of GTD.
- With placental site tumours, the HCG level may be slightly higher than normal, but it is not considered a good marker for this type of tumour.
- An HCG test can help find GTD after pregnancy or miscarriage as this hormone should not be present in the blood or urine soon afterward.
Human placental lactogen (hPL)
- Human placental lactogen (hPL) is a tumour marker that may be used to follow women with placental site trophoblastic tumours. High hPL levels are found in women with some types of GTD.
- Complete blood count- A CBC can check for anemia from long-term (chronic) vaginal bleeding.
Karyotyping
Hydatidiform moles (molar pregnancies) result from abnormal fertilization of an egg by 1 or more sperm, which may result in an abnormal number of chromosomes.
Flow cytometry
Flow cytometry helps determine the types of cells that are present. It also shows if there are an abnormal number of chromosomes, such as in hydatidiform moles.
Immunohistochemistry
Immunohistochemistry helps determine the types of cells that are present, which can be helpful in identifying hydatidiform moles.
- Kidney function tests
- Liver function tests