Ewing's sarcoma overview: Difference between revisions
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==Epidemiology and Demographics== | ==Epidemiology and Demographics== | ||
Ewing sarcoma is the second most common malignant bone tumor in patients younger than 20 years. Ewing sarcoma typically occurs in children and adolescents between 10 and 20 years of age. The overall incidence of Ewing sarcoma is 0.1 cases for 100,000 individuals. The incidence of Ewing sarcoma in children aged 10 to 19 years is 1 case for 100,000 individuals. Males are more commonly affected with Ewing sarcoma than females. | Ewing sarcoma is the second most common malignant bone tumor in patients younger than 20 years. Ewing sarcoma typically occurs in children and adolescents between 10 and 20 years of age. The overall incidence of Ewing sarcoma is 0.1 cases for 100,000 individuals. The incidence of Ewing sarcoma in children aged 10 to 19 years is 1 case for 100,000 individuals. Males are more commonly affected with Ewing sarcoma than females. | ||
==Risk Factors== | |||
Common risk factors in the development of Ewing sarcoma are age, gender, and race. | |||
==Screening== | |||
According to the the U.S. Preventive Service Task Force (USPSTF), there is insufficient evidence to recommend routine screening for Ewing sarcoma.<ref name=USPSTF>Ewing sarcoma. U.S. Preventive Services Task Force.http://www.uspreventiveservicestaskforce.org/BrowseRec/Search?s=ewing+sarcoma</ref> | |||
Revision as of 20:52, 13 October 2015
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Ewing's sarcoma Microchapters |
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Ewing's sarcoma overview On the Web |
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American Roentgen Ray Society Images of Ewing's sarcoma overview |
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Risk calculators and risk factors for Ewing's sarcoma overview |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Assistant Editor(s)-In-Chief: Michael Maddaleni, B.S.
Overview
Ewing's sarcoma is the common name for primitive neuroectodermal tumor. It is a rare disease, and until recently, it had a very low long term survival rate. It is a small round-cell tumor in which cancer cells are found in the bone or in soft tissue (rarer). The most common areas in which it occurs are the pelvis, the femur, the humerus, and the ribs.
Classification
There is no classification system established for Ewing sarcoma.
Pathophysiology
Ewing sarcoma may occur anywhere in the body, but most commonly in the pelvis and proximal long tubular bones. The pathogenesis of Ewing sarcoma include t(11;22) chromosomal translocation. On microscopic histopathological analysis, presence of small round cells that have a high nuclear to cytoplasmic ratio, vacuolated cytoplasm, and faded boundaries are characteristic findings of Ewing sarcoma.
Causes
There are no established causes for Ewing sarcoma.
Differential Diagnosis
Ewing sarcoma must be differentiated from osteosarcoma, hematological malignancy, eosinophilic granuloma, and malignant fibrous histiocytoma.
Epidemiology and Demographics
Ewing sarcoma is the second most common malignant bone tumor in patients younger than 20 years. Ewing sarcoma typically occurs in children and adolescents between 10 and 20 years of age. The overall incidence of Ewing sarcoma is 0.1 cases for 100,000 individuals. The incidence of Ewing sarcoma in children aged 10 to 19 years is 1 case for 100,000 individuals. Males are more commonly affected with Ewing sarcoma than females.
Risk Factors
Common risk factors in the development of Ewing sarcoma are age, gender, and race.
Screening
According to the the U.S. Preventive Service Task Force (USPSTF), there is insufficient evidence to recommend routine screening for Ewing sarcoma.[1]
References
- ↑ Ewing sarcoma. U.S. Preventive Services Task Force.http://www.uspreventiveservicestaskforce.org/BrowseRec/Search?s=ewing+sarcoma