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* Chronic lymphocytic leukemia must be differentiated from other diseases that cause weight loss,  night sweats, hepatosplenomegaly, and palpable lymph nodes, such as hairy cell leukaemia, prolymphocytic leukaemia, follicular lymphoma, and mantle cell lymphoma.
*The table below lists the risk factors for chronic lymphocytic leukmeia development:
* The table below summarizes how to differentiate chronic lymphocytic leukemia from other conditions that cause similar presentation:<ref>Hoffbrand V, Moss P. Essential Haematology. John Wiley & Sons; 2011</ref>
{|  
<br>
! style="background: #4479BA; width: 200px; color: #FFFFFF;"|'''Risk Factor'''
{| style="cellpadding=0; cellspacing= 0; width: 1100px;"
 
|-
! style="background: #4479BA; width: 600px; color: #FFFFFF;"|'''Description'''
|+
! style="background: #4479BA; width: 600px;" | {{fontcolor|#FFF|'''Differential Diagnosis'''}}
! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|'''Surface Immunoglobulin'''}}
! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|'''CD5'''}}
! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|'''CD22/FMC7'''}}
! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|'''CD23'''}}
! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|'''CD79b'''}}
! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|'''CD103'''}}


|-
|-


| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | '''Chemical exposure'''|| style="padding: 5px 5px; background: #F5F5F5;" |Exposure to [[herbicide]]s and [[insecticide]]s (used in farming) are correlated with an increased risk of chronic lymphocytic leukemia.
'''Chronic lymphocytic leukaemia'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center |
'''Weakly positive'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center |
'''Positive'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center |
'''Negative'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Positive'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Negative'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Positive/Negative'''
 
|-
|-


| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | '''Family history'''|| style="padding: 5px 5px; background: #F5F5F5;" |First-degree relatives of chronic lymphocytic leukemia patients have an increased risk to develop to the disease.
'''Prolymphocytic leukaemia'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Strongly positive'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Negative'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Positive'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Negative'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Positive'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Negative'''
 
|-
|-


| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | '''Gender'''|| style="padding: 5px 5px; background: #F5F5F5;" |Males are more commonly affected with chronic lymphocytic leukemia than females]
'''Hairy cell leukaemia'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Strongly positive'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Negative'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Positive'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Negative'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Positive/Negative'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Positive'''


|-
|-


| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | '''Age'''|| style="padding: 5px 5px; background: #F5F5F5;" |The chance to develop chronic lymphocytic leukemia increases as patients advance in age.
'''Mantle cell lymphoma'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Positive'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Positive'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Strongly positive'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
Negative
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Strongly positive'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Negative'''
 
|-
|-


| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | '''Trauma'''|| style="padding: 5px 5px; background: #F5F5F5;" | A positive history of head [[trauma]] increases the risk of meningioma
'''Follicular lymphoma'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Strongly positive'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Negative'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Positive'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Negative'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Strongly positive'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Negative'''
|}
|}
<br>
* Chronic lymphocytic leukemia must also be differentiated from other causes of fever, hepatosplenomegaly, and lymph node swelling such as:
:* Splenic marginal zone lymphoma
:* Nodal marginal zone lymphoma
:* Lymphoplasmacytic lymphoma
:* Sézary syndrome
:* Smoldering adult T cell leukemia<ref name="wiki>Chronic Lymphocytic Leukimea. Wikipedia (2015) https://en.wikipedia.org/wiki/B-cell_chronic_lymphocytic_leukemia Accessed on October ,12 2015</ref>

Revision as of 22:25, 13 October 2015

  • The table below lists the risk factors for chronic lymphocytic leukmeia development:
Risk Factor Description
Chemical exposure Exposure to herbicides and insecticides (used in farming) are correlated with an increased risk of chronic lymphocytic leukemia.
Family history First-degree relatives of chronic lymphocytic leukemia patients have an increased risk to develop to the disease.
Gender Males are more commonly affected with chronic lymphocytic leukemia than females]
Age The chance to develop chronic lymphocytic leukemia increases as patients advance in age.
Trauma A positive history of head trauma increases the risk of meningioma
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