Sandbox: prognosis: Difference between revisions

Revision as of 23:50, 13 October 2015


Prognostic Factor	Description

Gender	Males are associated with a worse prognosis
Stage	Binet stages B and C or Rai stages II–IV are associated with a worse prognosis
Lymphocyte doubling time	Deletion of chromosome 17 short arm is associated with a worse prognosis
Genetic mutations	Deletion of chromosome 17 short arm is associated with a worse prognosis
Histological analysis	Diffuse histology on bone marrow aspiration is associated with a worse prognosis
Lactate dehydrogenase (LDH) level	Elevated levels of LDH is associated with a worse prognosis
Lymphocyte surface marker	Positive expression of CD38 is associated with a worse prognosis
Immunoglobulin (Ig)VH gene	The absence of VH gene mutation is associated with a worse prognosis
Membrane-bound proteins	The expression of Zeta-chain-associated protein kinase 70 (ZAP)is associated with a poor prognosis

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 * The table below lists prognostic factors for chronic lymphocytic leukemia:<ref>Hoffbrand V, Moss P. Essential Haematology. John Wiley & Sons; 2011</ref>
-Gender Males are associated with a worse prognosis
-Stage  Binet stages B and C or Rai stages II–IV are associated with a worse prognosis
-Lymphocyte doubling time Rapid lymphocyte doubling time is associated with a worse prognosis
-Genetic mutations Deletion of chromosome 17 short arm is associated with a worse prognosis
-Histological analysis Diffuse histology on bone marrow aspiration is associated with a worse prognosis
-Lactate dehydrogenase (LDH) level Elevated levels of LDH is associated with a worse prognosis
-Lymphocyte surface marker Positive expression of CD38 is associated with a worse prognosis
-Immunoglobulin (Ig)VH gene The absence of VH gene mutation is associated with a worse prognosis
-Membrane protein The expression of Zeta-chain-associated protein kinase 70 (ZAP)is associated with a poor prognosis
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