Oligodendroglioma other diagnostic studies

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Overview

Other diagnostic studies for oligodendroglioma include biopsy (homogeneous, compact, rounded cells with distinct borders and clear cytoplasm surrounding a dense central nucleus and perinuclear halo) and fluorescent in-situ hybridization (FISH) technique (deletions of chromosome 1p and 19q).

Other Diagnostic Studies

Biopsy

• Biopsy may be performed to help confirm the diagnosis of oligodendroglioma.
• On biopsy, oligodendroglioma is characterized by homogeneous, compact, rounded cells with distinct borders and clear cytoplasm surrounding a dense central nucleus and perinuclear halo, giving it the characteristic “fried egg” appearance.
• Biopsy may be done at the time of surgical resection of oligodendroglioma.
• Biopsy may be of two types: open and stereotactic.
• Indications for open biopsy and stereotactic biopsy are described below:

Type of biopsy	Indications
Open biopsy	Surgically resectable masses Lesions in accessible and relatively “silent” areas of the brain or in areas of the brain with a mild postoperative neurologic deficit Appearance consistent with tumor on the MRI Large tumors exerting mass effect
Stereotactic biopsy	Deep-seated tumor that is not amenable to resection Lesions in which the radiological and clinical findings are ambiguous Diffuse or multiple lesions Appearance that suggests a lymphoma, which would not require resection Change in the appearance of a previously diagnosed or treated tumor Assessment of tumor after treatment (to distinguish between radiation necrosis and tumor recurrence)

Fluorescent in-situ hybridization (FISH) technique

• FISH demonstrates deletions of chromosome 1p and 19q.

References

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