Glucagonoma surgery: Difference between revisions
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==Surgery== | ==Surgery== | ||
Surgery is the mainstay of treatment for glucagonoma. The feasibility of surgery depends on the stage of glucagonoma at diagnosis.<ref name="pmid15313692">{{cite journal| author=Zhang M, Xu X, Shen Y, Hu ZH, Wu LM, Zheng SS| title=Clinical experience in diagnosis and treatment of glucagonoma syndrome. | journal=Hepatobiliary Pancreat Dis Int | year= 2004 | volume= 3 | issue= 3 | pages= 473-5 | pmid=15313692 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15313692 }} </ref><ref>Pancreatic Neuroendocrine Tumors (Islet Cell Tumors). National Cancer Institute. http://www.cancer.gov/types/pancreatic/hp/pnet-treatment-pdq#section/_88</ref> | Surgery is the mainstay of treatment for glucagonoma. The feasibility of surgery depends on the stage of glucagonoma at diagnosis.<ref name="pmid15313692">{{cite journal| author=Zhang M, Xu X, Shen Y, Hu ZH, Wu LM, Zheng SS| title=Clinical experience in diagnosis and treatment of glucagonoma syndrome. | journal=Hepatobiliary Pancreat Dis Int | year= 2004 | volume= 3 | issue= 3 | pages= 473-5 | pmid=15313692 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15313692 }} </ref><ref>Pancreatic Neuroendocrine Tumors (Islet Cell Tumors). National Cancer Institute. http://www.cancer.gov/types/pancreatic/hp/pnet-treatment-pdq#section/_88</ref> | ||
*Single, small lesion in head or tail of pancreas: | *Single, small lesion in head or tail of [[pancreas]]: | ||
:*Enucleation, if feasible | :*Enucleation, if feasible | ||
*Large lesion in the head of the pancreas that is not amenable to enucleation: | *Large lesion in the head of the pancreas that is not amenable to enucleation: | ||
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*Metastatic disease: [[lymph nodes]] or distant sites: | *Metastatic disease: [[lymph nodes]] or distant sites: | ||
:*Resect when possible | :*Resect when possible | ||
:*Consider radiofrequency or cryosurgical ablation, if not resectable | :*Consider [[radiofrequency]] or cryosurgical ablation, if not resectable | ||
*Unresectable disease: | *Unresectable disease: | ||
:*Combination chemotherapy | :*Combination [[chemotherapy]] | ||
:*[[Somatostatin]] analogue therapy. Necrotizing erythema of glucagonoma may be relieved in 24 hours with somatostatin analogue, with nearly complete disappearance within 1 week | :*[[Somatostatin]] analogue therapy. Necrotizing erythema of glucagonoma may be relieved in 24 hours with somatostatin analogue, with nearly complete disappearance within 1 week | ||
Revision as of 14:40, 16 October 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2]
Overview
Surgery is the mainstay of treatment for glucagonoma. The feasibility of surgery depends on the stage of glucagonoma at diagnosis.[1]
Surgery
Surgery is the mainstay of treatment for glucagonoma. The feasibility of surgery depends on the stage of glucagonoma at diagnosis.[1][2]
- Single, small lesion in head or tail of pancreas:
- Enucleation, if feasible
- Large lesion in the head of the pancreas that is not amenable to enucleation:
- Pancreaticoduodenectomy
- Single, large lesion in body/tail:
- Distal pancreatectomy
- Multiple lesions:
- Enucleation, if feasible
- Resect body and tail otherwise
- Metastatic disease: lymph nodes or distant sites:
- Resect when possible
- Consider radiofrequency or cryosurgical ablation, if not resectable
- Unresectable disease:
- Combination chemotherapy
- Somatostatin analogue therapy. Necrotizing erythema of glucagonoma may be relieved in 24 hours with somatostatin analogue, with nearly complete disappearance within 1 week
References
- ↑ 1.0 1.1 Zhang M, Xu X, Shen Y, Hu ZH, Wu LM, Zheng SS (2004). "Clinical experience in diagnosis and treatment of glucagonoma syndrome". Hepatobiliary Pancreat Dis Int. 3 (3): 473–5. PMID 15313692.
- ↑ Pancreatic Neuroendocrine Tumors (Islet Cell Tumors). National Cancer Institute. http://www.cancer.gov/types/pancreatic/hp/pnet-treatment-pdq#section/_88