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* The most common gene involved in the pathogenesis of hairy cell leukemia is BRAF V600E mutations. | * The most common gene involved in the pathogenesis of hairy cell leukemia is BRAF V600E mutations. | ||
* The BRAF V600E mutations is '''present''' in all patients with hairy cell leukemia '''classic'''. | * The BRAF V600E mutations is '''present''' in all patients with hairy cell leukemia '''classic'''. | ||
* The BRAF V600E mutations is '''not present''' in patients with hairy cell leukemia '''variant'''. | * The BRAF V600E mutations is '''not present''' in patients with hairy cell leukemia '''variant'''.<ref name="wiki"> Hairy cell leukemia. Wikipedia (2015) https://en.wikipedia.org/wiki/Hairy_cell_leukemia#Pathophysiology Accessed on Ocotber, 19 2015</ref> | ||
==Associated Conditions== | * Other genes involved in the pathogenesis of hairy cell leukemia include: | ||
:* Under expression of c | |||
The cells underexpress 3p24, 3p21, 3q13.3-q22, 4p16, 11q23, 14q22-q24, 15q21-q22, 15q24-q25, and 17q22-q24 and overexpress 13q31 and Xq13.3-q21==Associated Conditions== | |||
==Gross Pathology== | ==Gross Pathology== | ||
==Microscopic Pathology== | ==Microscopic Pathology== | ||
Revision as of 11:50, 20 October 2015
Overview
Pathogenesis
Genetics
- The most common gene involved in the pathogenesis of hairy cell leukemia is BRAF V600E mutations.
- The BRAF V600E mutations is present in all patients with hairy cell leukemia classic.
- The BRAF V600E mutations is not present in patients with hairy cell leukemia variant.[1]
- Other genes involved in the pathogenesis of hairy cell leukemia include:
- Under expression of c
The cells underexpress 3p24, 3p21, 3q13.3-q22, 4p16, 11q23, 14q22-q24, 15q21-q22, 15q24-q25, and 17q22-q24 and overexpress 13q31 and Xq13.3-q21==Associated Conditions==
Gross Pathology
Microscopic Pathology
- ↑ Hairy cell leukemia. Wikipedia (2015) https://en.wikipedia.org/wiki/Hairy_cell_leukemia#Pathophysiology Accessed on Ocotber, 19 2015