Oligoastrocytoma other diagnostic studies: Difference between revisions
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==Other Diagnostic Studies== | ==Other Diagnostic Studies== | ||
===Biopsy=== | ===Biopsy=== | ||
*Biopsy may be performed to help confirm the diagnosis of oligoastrocytoma. | *Biopsy may be performed to help confirm the diagnosis of oligoastrocytoma.<ref name=diagOAwiki>Diagnosis of oligoastrocytoma. Wikipedia 2015. https://en.wikipedia.org/wiki/Oligoastrocytoma. Accessed on October 20, 2015</ref> | ||
*On [[biopsy]], oligoastrocytoma is characterized by homogeneous, compact, rounded cells with distinct borders and clear cytoplasm surrounding a dense central nucleus and perinuclear halo, giving it the characteristic “''fried egg''” appearance. | *On [[biopsy]], oligoastrocytoma is characterized by homogeneous, compact, rounded cells with distinct borders and clear cytoplasm surrounding a dense central nucleus and perinuclear halo, giving it the characteristic “''fried egg''” appearance. | ||
*Biopsy may be done at the time of [[surgical resection]] of oligoastrocytoma. | *Biopsy may be done at the time of [[surgical resection]] of oligoastrocytoma. | ||
Revision as of 20:22, 20 October 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Other diagnostic studies for oligoastrocytoma include biopsy (homogeneous, compact, rounded cells with distinct borders and clear cytoplasm surrounding a dense central nucleus and perinuclear halo) and fluorescent in-situ hybridization (FISH) technique (deletions of chromosome 1p and 19q).[1][2]
Other Diagnostic Studies
Biopsy
- Biopsy may be performed to help confirm the diagnosis of oligoastrocytoma.[1]
- On biopsy, oligoastrocytoma is characterized by homogeneous, compact, rounded cells with distinct borders and clear cytoplasm surrounding a dense central nucleus and perinuclear halo, giving it the characteristic “fried egg” appearance.
- Biopsy may be done at the time of surgical resection of oligoastrocytoma.
- Biopsy may be of two types: open and stereotactic.
- Indications for open biopsy and stereotactic biopsy are described below:[3]
| Type of biopsy | Indications |
|---|---|
|
Fluorescent in-situ hybridization (FISH) technique
- 30-70% of oligoastrocytomas show loss of heterozygosity (LOH) of 1p and 19q.[4]
- FISH demonstrates deletions of chromosome 1p and 19q.[2]
References
- ↑ 1.0 1.1 Diagnosis of oligoastrocytoma. Wikipedia 2015. https://en.wikipedia.org/wiki/Oligoastrocytoma. Accessed on October 20, 2015
- ↑ 2.0 2.1 Ersen, Ayca (2008), Pathology of malignant gliomas: Challenges of everyday practice and the WHO 2007, Turkish Journal of Pathology, retrieved 20 October, 2015 Check date values in:
|accessdate=(help) - ↑ Eskandar EN, Loeffler JS, O'Neill AM, Hunter GJ, Louis DN (2004). "Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 33-2004. A 34-year-old man with a seizure and a frontal-lobe brain lesion". N Engl J Med. 351 (18): 1875–82. doi:10.1056/NEJMcpc049025. PMID 15509821.
- ↑ Mueller W, Hartmann C, Hoffmann A, Lanksch W, Kiwit J, Tonn J; et al. (2002). "Genetic signature of oligoastrocytomas correlates with tumor location and denotes distinct molecular subsets". Am J Pathol. 161 (1): 313–9. doi:10.1016/S0002-9440(10)64183-1. PMC 1850690. PMID 12107116.