Oligoastrocytoma natural history, complications and prognosis: Difference between revisions

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{{Oligodendroglioma}}
{{Oligoastrocytoma}}
{{CMG}}{{AE}}{{SR}}
{{CMG}}{{AE}}{{SR}}


==Overview==
==Overview==
If left untreated, patients with oligodendroglioma may progress to develop [[seizures]], focal neurological deficits, [[hydrocephalus]], [[brain herniation]], [[intracranial hemorrhage]], and ultimately death.<ref name="pmid20375839">{{cite journal| author=Manousaki M, Papadaki H, Papavdi A, Kranioti EF, Mylonakis P, Varakis J et al.| title=Sudden unexpected death from oligodendroglioma: a case report and review of the literature. | journal=Am J Forensic Med Pathol | year= 2011 | volume= 32 | issue= 4 | pages= 336-40 | pmid=20375839 | doi=10.1097/PAF.0b013e3181d3dc86 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20375839  }} </ref> Common complications associated with oligodendroglioma include [[hydrocephalus]], [[intracranial hemorrhage]], [[coma]], [[metastasis|bone marrow metastasis]], recurrence, [[venous thromboembolism]], [[parkinsonism]], and side effects of [[chemotherapy]] and [[radiotherapy]].<ref name="pmid26251628">{{cite journal| author=Simonetti G, Gaviani P, Botturi A, Innocenti A, Lamperti E, Silvani A| title=Clinical management of grade III oligodendroglioma. | journal=Cancer Manag Res | year= 2015 | volume= 7 | issue=  | pages= 213-23 | pmid=26251628 | doi=10.2147/CMAR.S56975 | pmc=PMC4524382 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26251628  }} </ref><ref name="pmid19558288">{{cite journal| author=Guppy KH, Akins PT, Moes GS, Prados MD| title=Spinal cord oligodendroglioma with 1p and 19q deletions presenting with cerebral oligodendrogliomatosis. | journal=J Neurosurg Spine | year= 2009 | volume= 10 | issue= 6 | pages= 557-63 | pmid=19558288 | doi=10.3171/2009.2.SPINE08853 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19558288  }} </ref><ref name="pmid12800473">{{cite journal| author=Sharma A, Agarwal A, Sharma MC, Anand M, Agarwal S, Raina V| title=Bone marrow metastasis in anaplastic oligodendroglioma. | journal=Int J Clin Pract | year= 2003 | volume= 57 | issue= 4 | pages= 351-2 | pmid=12800473 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12800473  }} </ref><ref name="pmid6051252">{{cite journal| author=Solitare GB, Robinson F, Lamarche JB| title=Oligodendroglioma: recurrence following an exceptionally long postoperative symptom-free interval. | journal=Can Med Assoc J | year= 1967 | volume= 97 | issue= 14 | pages= 862-5 | pmid=6051252 | doi= | pmc=PMC1923454 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6051252  }} </ref><ref name="pmid6176898">{{cite journal| author=Harada K, Kiya K, Matsumura S, Mori S, Uozumi T| title=Spontaneous intracranial hemorrhage caused by oligodendroglioma--a case report and review of the literature. | journal=Neurol Med Chir (Tokyo) | year= 1982 | volume= 22 | issue= 1 | pages= 81-4 | pmid=6176898 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6176898  }} </ref><ref name="pmid12619787">{{cite journal| author=Hentschel S, Toyota B| title=Intracranial malignant glioma presenting as subarachnoid hemorrhage. | journal=Can J Neurol Sci | year= 2003 | volume= 30 | issue= 1 | pages= 63-6 | pmid=12619787 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12619787  }} </ref><ref name="pmid8561031">{{cite journal| author=Krauss JK, Paduch T, Mundinger F, Seeger W| title=Parkinsonism and rest tremor secondary to supratentorial tumours sparing the basal ganglia. | journal=Acta Neurochir (Wien) | year= 1995 | volume= 133 | issue= 1-2 | pages= 22-9 | pmid=8561031 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8561031  }} </ref> Depending on the extent and grade of the tumor at the time of diagnosis, the prognosis of oligodendroglioma may vary.  However, the prognosis is generally regarded as good. The [[median]] survival time for oligodendroglioma is 11.6 years for grade II and 3.5 years for grade III.<ref name="pmid15977639">{{cite journal| author=Ohgaki H, Kleihues P| title=Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas. | journal=J Neuropathol Exp Neurol | year= 2005 | volume= 64 | issue= 6 | pages= 479-89 | pmid=15977639 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15977639  }} </ref>


==Natural history==
==Natural history==
*Oligoastrocytomas are slow growing tumors.<ref name=pathoOA1>{{cite book | last = Adesina | first = Adekunle | title = Atlas of pediatric brain tumors | publisher = Springer | location = New York | year = 2010 | isbn = 9781441910622 }}</ref> The tumors may be present for many years before they are diagnosed.<ref name=surv>Survival by prognostic factors. Canadian Cancer Society 2015. http://www.cancer.ca/en/cancer-information/cancer-type/brain-spinal/prognosis-and-survival/survival-statistics/?region=on</ref>
*Oligoastrocytomas are slow growing tumors.<ref name=pathoOA1>{{cite book | last = Adesina | first = Adekunle | title = Atlas of pediatric brain tumors | publisher = Springer | location = New York | year = 2010 | isbn = 9781441910622 }}</ref> The tumors may be present for many years before they are diagnosed.<ref name=surv>Survival by prognostic factors. Canadian Cancer Society 2015. http://www.cancer.ca/en/cancer-information/cancer-type/brain-spinal/prognosis-and-survival/survival-statistics/?region=on</ref>
*If left untreated, patients with oligoastrocytoma may progress to develop [[seizures]], focal neurological deficits, [[hydrocephalus]], [[brain herniation]], [[intracranial hemorrhage]], and ultimately death.<ref name="pmid18533376">{{cite journal| author=Chandana SR, Movva S, Arora M, Singh T| title=Primary brain tumors in adults. | journal=Am Fam Physician | year= 2008 | volume= 77 | issue= 10 | pages= 1423-30 | pmid=18533376 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18533376  }} </ref>
*If left untreated, patients with oligoastrocytoma may progress to develop [[seizures]], focal neurological deficits, [[hydrocephalus]], [[brain herniation]], [[intracranial hemorrhage]], and ultimately death.<ref name="pmid18533376">{{cite journal| author=Chandana SR, Movva S, Arora M, Singh T| title=Primary brain tumors in adults. | journal=Am Fam Physician | year= 2008 | volume= 77 | issue= 10 | pages= 1423-30 | pmid=18533376 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18533376 }} </ref><ref name="Grier2006">{{cite journal|last1=Grier|first1=J. T.|title=Low-Grade Gliomas in Adults|journal=The Oncologist|volume=11|issue=6|year=2006|pages=681–693|issn=1083-7159|doi=10.1634/theoncologist.11-6-681}}</ref><ref name="pmid3748360">{{cite journal| author=Specht CS, Pinto-Lord C, Smith TW, DeGirolami U, Suran E, Marshall PC et al.| title=Spontaneous hemorrhage in a mixed glioma of the cerebellum: case report. | journal=Neurosurgery | year= 1986 | volume= 19 | issue= 2 | pages= 278-81 | pmid=3748360 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3748360 }} </ref>
*The mixed gliomas with a 1p/19q loss would behave in an indolent or chemo-responsive fashion as expected of an oligodendroglioma, whereas those without this profile act biologically like astrocytic tumors, i.e. more aggressively and more prone to high grade transformation .<ref name=OAnatho1>{{Citation |last=Tihan |first=T. |last= Ersen |first=A. |year=2008 |title=Pathology of malignant gliomas: Challenges of everyday practice and the WHO 2007 |publisher=Turkish Journal of Pathology |publication-place= |page= 194-212 |url=http://www.turkjpath.org/text.php3?id=645#r75 |accessdate=October 20, 2015 }}</ref>
*The mixed gliomas with a 1p/19q loss would behave in an indolent or chemo-responsive fashion as expected of an oligodendroglioma, whereas those without this profile act biologically like astrocytic tumors, i.e. more aggressively and more prone to high grade transformation .<ref name=OAnatho1>{{Citation |last=Tihan |first=T. |last= Ersen |first=A. |year=2008 |title=Pathology of malignant gliomas: Challenges of everyday practice and the WHO 2007 |publisher=Turkish Journal of Pathology |publication-place= |page= 194-212 |url=http://www.turkjpath.org/text.php3?id=645#r75 |accessdate=October 20, 2015 }}</ref>


Revision as of 16:18, 21 October 2015

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Overview

Natural history

  • Oligoastrocytomas are slow growing tumors.[1] The tumors may be present for many years before they are diagnosed.[2]
  • If left untreated, patients with oligoastrocytoma may progress to develop seizures, focal neurological deficits, hydrocephalus, brain herniation, intracranial hemorrhage, and ultimately death.[3][4][5]
  • The mixed gliomas with a 1p/19q loss would behave in an indolent or chemo-responsive fashion as expected of an oligodendroglioma, whereas those without this profile act biologically like astrocytic tumors, i.e. more aggressively and more prone to high grade transformation .[6]

Complications

Common complications associated with oligoastrocytoma include:[4][7][8][3][9][5]

Prognosis

  • Depending on the extent and grade of the tumor at the time of diagnosis, the prognosis of oligoastrocytoma may vary. However, the prognosis is generally regarded as good.[10]
  • The prognosis for patients with oligoastrocytoma is more favorable than that for anaplastic oligoastrocytoma because of the more indolent course and younger age at which most patients are diagnosed.[4]
  • The 1, 5, and 10-year survival rates of patients with oligoastrocytoma are approximately 87%, 56.97%, and 45.80%.[11]
  • Favorable prognostic factors for oligoastrocytoma include:[12][13][7][14][15][3]
  • Presence of microvascular proliferation and necrosis are poor prognostic factors for oligoastrocytoma.[16]

References

  1. ↑ Adesina, Adekunle (2010). Atlas of pediatric brain tumors. New York: Springer. ISBN 9781441910622.
  2. ↑ Survival by prognostic factors. Canadian Cancer Society 2015. http://www.cancer.ca/en/cancer-information/cancer-type/brain-spinal/prognosis-and-survival/survival-statistics/?region=on
  3. ↑ 3.0 3.1 3.2 Chandana SR, Movva S, Arora M, Singh T (2008). "Primary brain tumors in adults". Am Fam Physician. 77 (10): 1423–30. PMID 18533376.
  4. ↑ 4.0 4.1 4.2 Grier, J. T. (2006). "Low-Grade Gliomas in Adults". The Oncologist. 11 (6): 681–693. doi:10.1634/theoncologist.11-6-681. ISSN 1083-7159.
  5. ↑ 5.0 5.1 Specht CS, Pinto-Lord C, Smith TW, DeGirolami U, Suran E, Marshall PC; et al. (1986). "Spontaneous hemorrhage in a mixed glioma of the cerebellum: case report". Neurosurgery. 19 (2): 278–81. PMID 3748360.
  6. ↑ Ersen, A. (2008), Pathology of malignant gliomas: Challenges of everyday practice and the WHO 2007, Turkish Journal of Pathology, p. 194-212, retrieved October 20, 2015
  7. ↑ 7.0 7.1 Stupp R, Tonn JC, Brada M, Pentheroudakis G, ESMO Guidelines Working Group (2010). "High-grade malignant glioma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up". Ann Oncol. 21 Suppl 5: v190–3. doi:10.1093/annonc/mdq187. PMID 20555079.
  8. ↑ Signs and symptoms of glioma. Wikipedia 2015. https://en.wikipedia.org/wiki/Glioma. Accessed on October 20, 2015
  9. ↑ Finsterer J, Breiteneder S, Mueller MR, Wogritsch C, Vesely M, Kleinert R; et al. (1998). "Pleural and bone marrow metastasis from supratentorial oligoastrocytoma grade III". Oncology. 55 (4): 345–8. PMID 9663425.
  10. ↑ Liang Y, Bollen AW, Nicholas MK, Gupta N (2005). "Id4 and FABP7 are preferentially expressed in cells with astrocytic features in oligodendrogliomas and oligoastrocytomas". BMC Clin Pathol. 5: 6. doi:10.1186/1472-6890-5-6. PMC 1182359. PMID 16018821.
  11. ↑ One–, Two–, Three–, Four–, Five–, and 10–year relative survival rates for selected malignant brain and central nervous system tumors, Seer 17 Registries, 1995-2006. CBTRUS 2015. http://www.cbtrus.org/2010-NPCR-SEER/CBTRUS-WEBREPORT-Final-3-2-10.pdf. Accessed on October 16, 2015
  12. ↑ Pathology of oligoastrocytoma. Dr Bruno Di Muzio and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/oligoastrocytoma. Accessed on October 16, 2015
  13. ↑ Naugle DK, Duncan TD, Grice GP (2004). "Oligoastrocytoma". Radiographics. 24 (2): 598–600. doi:10.1148/rg.242035069. PMID 15026604.
  14. ↑ Prognosis of oligoastrocytoma. American Brain Tumor Association 2015. http://www.abta.org/secure/oligodendrioma-oligo.pdf. Accessed on October 21, 2015
  15. ↑ Pouratian N, Schiff D (2010). "Management of low-grade glioma". Curr Neurol Neurosci Rep. 10 (3): 224–31. doi:10.1007/s11910-010-0105-7. PMC 2857752. PMID 20425038.
  16. ↑ Miller, C. R.; Dunham, C. P.; Scheithauer, B. W.; Perry, A. (2006). "Significance of Necrosis in Grading of Oligodendroglial Neoplasms: A Clinicopathologic and Genetic Study of Newly Diagnosed High-Grade Gliomas". Journal of Clinical Oncology. 24 (34): 5419–5426. doi:10.1200/JCO.2006.08.1497. ISSN 0732-183X.


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