Sandbox: DDx 2: Difference between revisions

Revision as of 00:09, 22 October 2015


Differential Diagnosis	Key Symptoms	Characteristic Lab Findings	CT Scan	Characteristic Histopathological Features

Insulinoma	Diaphoresis Tremor Palpitations Seizures Coma	Hypoglycemia Hyperinsulinemia Elevated C-peptide level Elevated Pro-insulin level	Calcification and hyperattenuation of the mass	Solid or gyriform cellular patterns Amyloid deposition Nesidioblastosis may be present Absence of glands
VIPoma	Watery diarrhea Dehydration Lethargy Muscle weakness Flushing	Elevated (VIP) levels Elevated neurotensin levels Hypokalemia Hypomagnesaemia Hypercalcaemia Metabolic acidosis	Hypervascularity with diffuse multiple metastatic nodulation	Solid sheets Uniform cuboidal cells Centrally located nuclei Stippled chromatin Granular eosinophilic cytoplasm
Tumor stage	M0 stage confirmed by MRI and CSF sampling	M1-M3 stage or presence of leptomeningeal seeding	M0 stage confirmed by MRI and CSF sampling	M1-M3 stage or presence of leptomeningeal seeding

Solid or gyriform cellular patterns
Amyloid deposition
Nesidioblastosis may be present
Absence of glands

@@ Line 5: / Line 5: @@
 ! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|'''Key Symptoms'''}}
 ! style="background: #4479BA; width: 450px;" | {{fontcolor|#FFF|'''Characteristic Lab Findings'''}}
-! style="background: #4479BA; width: 450px;" | {{fontcolor|#FFF|'''Imaging'''}}
+! style="background: #4479BA; width: 450px;" | {{fontcolor|#FFF|'''CT Scan'''}}
-! style="background: #4479BA; width: 450px;" | {{fontcolor|#FFF|'''Histopathology'''}}
+! style="background: #4479BA; width: 450px;" | {{fontcolor|#FFF|'''Characteristic Histopathological Features'''}}
 |-
@@ Line 13: / Line 13: @@
 '''Insulinoma'''
 | style="padding: 5px 5px; background: #F5F5F5;"|
-* Weight loss
+* Diaphoresis
-* Vague abdominal pain
+* Tremor
-* Loss of appetite
+* Palpitations
-* Nausea and vomiting
+* Seizures
-* Jaundice
+* Coma
-* Anxiety
-* '''Diaphoresis'''
-* '''Tremor'''
-* '''Palpitations'''
-* '''Seizures'''
-* '''Coma'''
 | style="padding: 5px 5px; background: #F5F5F5;" |
-* '''Hypoglycemia'''
+* Hypoglycemia
-* '''Hyperinsulinemia'''
+* Hyperinsulinemia
-* '''Elevated C-peptide level'''
+* Elevated C-peptide level
-* '''Elevated Pro-insulin level'''
+* Elevated Pro-insulin level
 | style="padding: 5px 5px; background: #F5F5F5;" |
-* Solid or gyriform patterns, usually without glands
+* Calcification and hyperattenuation of the mass
+| style="padding: 5px 5px; background: #F5F5F5;" |
+* Solid or gyriform cellular patterns
+* Amyloid deposition
+* Nesidioblastosis may be present
+* Absence of glands
 |-
@@ Line 36: / Line 36: @@
 '''VIPoma'''
 | style="padding: 5px 5px; background: #F5F5F5;" |
-::::<1.5 cm² residual tumor after resection
+* Watery diarrhea
+* Dehydration
+* Lethargy
+* Muscle weakness
+* Flushing
 | style="padding: 5px 5px; background: #F5F5F5;" |
-::Subtotal resection '''or''' >1.5 cm² residual tumor after resection
+* Elevated (VIP) levels
+* Elevated neurotensin levels
+* Hypokalemia
+* Hypomagnesaemia
+* Hypercalcaemia
+* Metabolic acidosis
 | style="padding: 5px 5px; background: #F5F5F5;" |
-::::<1.5 cm² residual tumor after resection
+* Hypervascularity with diffuse multiple metastatic nodulation
 | style="padding: 5px 5px; background: #F5F5F5;" |
-::Subtotal resection '''or''' >1.5 cm² residual tumor after resection
+* Solid sheets
+* Uniform cuboidal cells
+* Centrally located nuclei
+* Stippled chromatin
+* Granular eosinophilic cytoplasm
 |-
@@ Line 58: / Line 71: @@
 :::M1-M3 stage '''or''' presence of [[leptomeningeal]] seeding
 |}
+* Solid or gyriform cellular patterns
+* Amyloid deposition
+* Nesidioblastosis may be present
+* Absence of glands

Sandbox: DDx 2: Difference between revisions

Revision as of 00:09, 22 October 2015

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