Myeloproliferative neoplasm laboratory findings: Difference between revisions
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Laboratory findings consistent with the diagnosis of myeloproliferative neoplasm include [[leukocytosis]], [[thrombocytopenia]], and [[anemia]]. | Laboratory findings consistent with the diagnosis of myeloproliferative neoplasm include [[leukocytosis]], [[thrombocytopenia]], and [[anemia]]. | ||
==Laboratory Findings== | ==Laboratory Findings== | ||
Laboratory findings associated with chronic myelogenous leukemia include:<ref name="cancer.ca">Canadian Cancer Society.2015.http://www.cancer.ca/en/cancer-information/cancer-type/leukemia-chronic-myelogenous-cml/diagnosis/?region=ab</ref> | Laboratory findings associated with chronic myelogenous leukemia include:<ref name="cancer.ca">Canadian Cancer Society.2015.http://www.cancer.ca/en/cancer-information/cancer-type/leukemia-chronic-myelogenous-cml/diagnosis/?region=ab</ref><ref>{{Cite journal | ||
<ref>{{Cite journal | |||
| author = [[James W. Vardiman]] | | author = [[James W. Vardiman]] | ||
| title = Chronic myelogenous leukemia, BCR-ABL1+ | | title = Chronic myelogenous leukemia, BCR-ABL1+ | ||
| Line 45: | Line 44: | ||
::*Inversions | ::*Inversions | ||
::*loss or gain of a chromosome number | ::*loss or gain of a chromosome number | ||
*Fluorescent in situ hybridization (FISH) | *[[Fluorescent in situ hybridization]] (FISH) | ||
:*Similar to cytogenetics, but more specific | :*Similar to cytogenetics, but more specific | ||
*Polymerase chain reaction | *Polymerase chain reaction | ||
Revision as of 14:12, 26 October 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2]
Overview
Laboratory findings consistent with the diagnosis of myeloproliferative neoplasm include leukocytosis, thrombocytopenia, and anemia.
Laboratory Findings
Laboratory findings associated with chronic myelogenous leukemia include:[1][2][3]
- Increased granulocytes of all types
- Increased basophils and eosinophils
- Thrombocytopenia
- Anemia
- Blood chemistry
- The following blood levels may be elevated:
- Blood urea nitrogen (BUN)
- Creatinine
- Phosphate
- Lactate dehydrogenase (LDH)
- Alanine aminotransferase (ALT)
- Aspartate transaminase (AST)
- Uric acid
- Bleeding and clotting factor
- The following blood levels may be elevated:
- Prothrombin time (PT) or international normalized ratio (INR)
- Partial thromboplastin time (PTT)
- Cytochemistry helps determine the type of cells that are present
- Flow cytometry helps determine the type of cells that are present
- Chromosome changes that may occur in some people with leukemia include:
- Translocations
- Inversions
- loss or gain of a chromosome number
- Similar to cytogenetics, but more specific
- Polymerase chain reaction
- Helpful to detect specific abnormalities in blood or bone marrow cells. Abnormalities can be found even if very few leukemia cells are present in a tissue sample.
- Red cell mass determination (for polycythaemia)
- Neutrophil alkaline phosphatase level
- Vitamin B12 (or B12 binding capacity)
- Serum urate.[4]
References
- ↑ Canadian Cancer Society.2015.http://www.cancer.ca/en/cancer-information/cancer-type/leukemia-chronic-myelogenous-cml/diagnosis/?region=ab
- ↑ James W. Vardiman (2009). "Chronic myelogenous leukemia, BCR-ABL1+". American journal of clinical pathology. 132 (2): 250–260. doi:10.1309/AJCPUN89CXERVOVH. PMID 19605820. Unknown parameter
|month=ignored (help) - ↑ Sánchez-Muñoz, Laura; Alvarez-Twose, Ivan; García-Montero, Andrés C; Teodosio, Cristina; Jara-Acevedo, María; Pedreira, Carlos E; Matito, Almudena; Morgado, Jose Mario T; Sánchez, Maria Luz; Mollejo, Manuela; Gonzalez-de-Olano, David; Orfao, Alberto; Escribano, Luis (2011). "Evaluation of the WHO criteria for the classification of patients with mastocytosis". Modern Pathology. 24 (9): 1157–1168. doi:10.1038/modpathol.2011.84. ISSN 0893-3952.
- ↑ Levene, Malcolm I.; Lewis, S. M.; Bain, Barbara J.; Imelda Bates. Dacie & Lewis Practical Haematology. London: W B Saunders. p. 586. ISBN 0-443-06377-X.