Chronic myelogenous leukemia differential diagnosis: Difference between revisions
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:*Leukemoid reaction associated with: | :*Leukemoid reaction associated with: | ||
::* High [[leukocyte alkaline phosphatase]] | ::* High [[leukocyte alkaline phosphatase]] | ||
::*[[White blood cell]] counts lower than 50 × | ::*[[White blood cell]] counts lower than 50 × 10^9/L | ||
::*Döhle's bodies in the [[granulocyte]]s | ::*Döhle's bodies in the [[granulocyte]]s | ||
::*Absence of [[basophilia]] | ::*Absence of [[basophilia]] | ||
Revision as of 18:33, 10 November 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2]
Overview
Chronic myelogenous leukemia must be differentiated from leukemoid reaction, chronic neutrophilic leukemia, and acute myeloid leukemia.[1]
Differential Diagnosis
Chronic myelogenous leukemia must be differentiated from:[1][2][3]
- Leukemoid reaction associated with:
- High leukocyte alkaline phosphatase
- White blood cell counts lower than 50 × 10^9/L
- Döhle's bodies in the granulocytes
- Absence of basophilia
- Basophils and eosinophils are almost always increased in chronic myelogenous leukemia
References
- ↑ 1.0 1.1 Gajendra S, Gupta R, Chandgothia M, Kumar L, Gupta R, Chavan SM (2014). "Chronic Neutrophilic Leukemia with V617F JAK2 Mutation". Indian J Hematol Blood Transfus. 30 (2): 139–42. doi:10.1007/s12288-012-0203-6. PMC 4022913. PMID 24839370.
- ↑ Kanegae MP, Ximenes VF, Falcão RP, Colturato VA, de Mattos ER, Brunetti IL; et al. (2007). "Chemiluminescent determination of leukocyte alkaline phosphatase: an advantageous alternative to the cytochemical assay". J Clin Lab Anal. 21 (2): 91–6. doi:10.1002/jcla.20140. PMID 17385676.
- ↑ Jabbour E, Kantarjian H (2014). "Chronic myeloid leukemia: 2014 update on diagnosis, monitoring, and management". Am J Hematol. 89 (5): 547–56. doi:10.1002/ajh.23691. PMID 24729196.