Renal oncocytoma pathophysiology: Difference between revisions
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==Pathogenesis== | ==Pathogenesis== | ||
* Renal oncocytoma is thought to arise from the [[intercalated cells]] of [[collecting ducts]] of the [[kidney]]. | * Renal oncocytoma is thought to arise from the [[intercalated cells]] of [[collecting ducts]] of the [[kidney]].<ref name="pmid6606945">{{cite journal |vauthors=Velasquez G, Glass TA, D'Souza VJ, Formanek AG |title=Multiple oncocytomas and renal carcinoma |journal=AJR Am J Roentgenol |volume=142 |issue=1 |pages=123–4 |year=1984 |pmid=6606945 |doi=10.2214/ajr.142.1.123 |url=http://www.ajronline.org/doi/abs/10.2214/ajr.142.1.123}}</ref> | ||
==Gross Pathology== | ==Gross Pathology== | ||
* The [[tumors]] are tan or mahogany brown, well circumscribed and contain a central scar. They may achieve a large size (up to 12 cm in diameter). | * The [[tumors]] are tan or mahogany brown, well circumscribed and contain a central scar. They may achieve a large size (up to 12 cm in diameter).<ref name="pmid6606945">{{cite journal |vauthors=Velasquez G, Glass TA, D'Souza VJ, Formanek AG |title=Multiple oncocytomas and renal carcinoma |journal=AJR Am J Roentgenol |volume=142 |issue=1 |pages=123–4 |year=1984 |pmid=6606945 |doi=10.2214/ajr.142.1.123 |url=http://www.ajronline.org/doi/abs/10.2214/ajr.142.1.123}}</ref> | ||
==Microscopic Pathology== | ==Microscopic Pathology== | ||
* An epithelial tumor composed of | * An epithelial tumor composed of oncocytes, large [[eosinophilic]] cells having small, round, benign-appearing [[nuclei]] with large [[nucleoli]] with excessive amounts of [[mitochondria]].<ref name="pmid2028856">{{cite journal |vauthors=Palmer WE, Chew FS |title=Renal oncocytoma |journal=AJR Am J Roentgenol |volume=156 |issue=6 |pages=1144 |year=1991 |pmid=2028856 |doi=10.2214/ajr.156.6.2028856 |url=http://www.ajronline.org/doi/abs/10.2214/ajr.156.6.2028856}}</ref> | ||
==References== | ==References== |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
On gross pathology, tan or mahogany brown, well circumscribed, and central scar are characteristic findings of the tumor of renal oncocytoma.
Pathogenesis
- Renal oncocytoma is thought to arise from the intercalated cells of collecting ducts of the kidney.[1]
Gross Pathology
- The tumors are tan or mahogany brown, well circumscribed and contain a central scar. They may achieve a large size (up to 12 cm in diameter).[1]
Microscopic Pathology
- An epithelial tumor composed of oncocytes, large eosinophilic cells having small, round, benign-appearing nuclei with large nucleoli with excessive amounts of mitochondria.[2]
References
- ↑ 1.0 1.1 Velasquez G, Glass TA, D'Souza VJ, Formanek AG (1984). "Multiple oncocytomas and renal carcinoma". AJR Am J Roentgenol. 142 (1): 123–4. doi:10.2214/ajr.142.1.123. PMID 6606945.
- ↑ Palmer WE, Chew FS (1991). "Renal oncocytoma". AJR Am J Roentgenol. 156 (6): 1144. doi:10.2214/ajr.156.6.2028856. PMID 2028856.