Renal oncocytoma biopsy: Difference between revisions
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{{CMG}} | {{CMG}} | ||
==Overview== | ==Overview== | ||
On [[biopsy]], renal oncocytoma is characterized by oncocytes and large [[eosinophilic]] cells. | |||
==Biopsy== | ==Biopsy== | ||
* On biopsy, renal oncocytoma is characterized by oncocytes and large [[eosinophilic]] cells. | * On biopsy, renal oncocytoma is characterized by oncocytes and large [[eosinophilic]] cells. | ||
* Biopsy is insufficient to distinguish renal oncocytoma from [[renal cell carcinoma]], therefore immunostaining may be required. | * Biopsy is insufficient to distinguish renal oncocytoma from [[renal cell carcinoma]], therefore immunostaining may be required.<ref name="pmid11748579">{{cite journal |vauthors=Liu J, Fanning CV |title=Can renal oncocytomas be distinguished from renal cell carcinoma on fine-needle aspiration specimens? A study of conventional smears in conjunction with ancillary studies |journal=[[Cancer]] |volume=93 |issue=6 |pages=390–7 |year=2001 |pmid=11748579 |doi= |url= |issn=}}</ref> | ||
* Immunohistochemical profile<ref>[Renal Neoplasms: An Update on Immunohistochemical and Histochemical Features http://www.dako.com/08066_12may10_webchapter26.pdf]</ref> | * Immunohistochemical profile<ref>[Renal Neoplasms: An Update on Immunohistochemical and Histochemical Features http://www.dako.com/08066_12may10_webchapter26.pdf]</ref> | ||
*[[Cytokeratin]] AE1/AE3 + | :* [[Cytokeratin]] AE1/AE3 + | ||
*[[Vimentin]] - | :* [[Vimentin]] - | ||
*Epithelial membrane antigen + | :* Epithelial membrane antigen + | ||
*[[CD10]]+/- | :* [[CD10]]+/- | ||
*CK7 +/- parcellaire | :* CK7 +/- parcellaire | ||
*CK20 - | :* CK20 - | ||
*CK19 - | :* CK19 - | ||
*[[AMACR]] ([[Racemase]]) - | :* [[AMACR]] ([[Racemase]]) - | ||
*S100 + | :* S100 + | ||
*c-kit ([[CD117]]) + | :* c-kit ([[CD117]]) + | ||
*Cadherin-E + | :* Cadherin-E + | ||
*[[TFE3]] - | :* [[TFE3]] - | ||
*CAM5.2 + | :* CAM5.2 + | ||
==References== | ==References== |
Revision as of 19:14, 28 October 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
On biopsy, renal oncocytoma is characterized by oncocytes and large eosinophilic cells.
Biopsy
- On biopsy, renal oncocytoma is characterized by oncocytes and large eosinophilic cells.
- Biopsy is insufficient to distinguish renal oncocytoma from renal cell carcinoma, therefore immunostaining may be required.[1]
- Immunohistochemical profile[2]
References
- ↑ Liu J, Fanning CV (2001). "Can renal oncocytomas be distinguished from renal cell carcinoma on fine-needle aspiration specimens? A study of conventional smears in conjunction with ancillary studies". Cancer. 93 (6): 390–7. PMID 11748579.
- ↑ [Renal Neoplasms: An Update on Immunohistochemical and Histochemical Features http://www.dako.com/08066_12may10_webchapter26.pdf]