Sandbox: HCL therapy: Difference between revisions
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==Overview== | ==Overview== | ||
==Medical Therapy== | ==Medical Therapy== | ||
* The mainstay of therapy for hairy cell leukemia patients is chemotherapy. | |||
* Asymptomatic hairy cell leukemia patients, with no indications for therapy, may be managed by observation and close follow-up. | |||
* Indications to initiate medical therapy among patients with hairy cell leukemia include: | * Indications to initiate medical therapy among patients with hairy cell leukemia include: | ||
:* The presence of systemic symptoms such as fever, night sweats, and significant weight loss | :* The presence of systemic symptoms such as fever, night sweats, and significant weight loss | ||
Line 8: | Line 10: | ||
:* Platelets count lower than 100,000/mcl | :* Platelets count lower than 100,000/mcl | ||
:* Absolute neutrophil count lower than 1000/mcl | :* Absolute neutrophil count lower than 1000/mcl | ||
* Pharmacological agents used for the treatment of hairy cell leukemia patients include: | * Pharmacological agents used for the treatment of hairy cell leukemia patients include: | ||
:* [[Cladribine]] | :* [[Cladribine]] |
Revision as of 23:15, 29 October 2015
Overview
Medical Therapy
- The mainstay of therapy for hairy cell leukemia patients is chemotherapy.
- Asymptomatic hairy cell leukemia patients, with no indications for therapy, may be managed by observation and close follow-up.
- Indications to initiate medical therapy among patients with hairy cell leukemia include:
- The presence of systemic symptoms such as fever, night sweats, and significant weight loss
- The presence of subcostal abdominal discomfort due splenic distension
- Positive history of recurrent infections.
- Hemoglobin concentration lower than 12 g/dl
- Platelets count lower than 100,000/mcl
- Absolute neutrophil count lower than 1000/mcl
- Pharmacological agents used for the treatment of hairy cell leukemia patients include: