Sandbox:DDx HEENT: Difference between revisions
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* Invasion of capsule and surrounding parenchyma/blood vessels on true cut biopsy | * Invasion of capsule and surrounding parenchyma/blood vessels on true cut biopsy | ||
* Thick calcified capsule present | * Thick calcified capsule present | ||
* Follicular/solid growth pattern with Hürthle cells | * Follicular/solid growth pattern with Hürthle cells, nuclear atypia, and increased mitotic activity on FNA | ||
Revision as of 16:37, 1 November 2015
- 40-60 yo women
- May have bone pain or respiratory symptoms
- Painless thyroid nodule
- Invasion of capsule and surrounding parenchyma/blood vessels on true cut biopsy
- Thick calcified capsule present
- Follicular/solid growth pattern with Hürthle cells, nuclear atypia, and increased mitotic activity on FNA
- Hypoechoic solid solitary mass on U/S
- RAS oncogene activation
- PAX8-PPAR gamma 1 genes rearrangement