Sandbox: T cell: Difference between revisions
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Adult T‐cell leukaemia/lymphoma (ATLL) is a mature T‐cell neoplasm of post‐thymic lymphocytes | Adult T‐cell leukaemia/lymphoma (ATLL) is a mature T‐cell neoplasm of post‐thymic lymphocytes | ||
Etiologically linked to the human T‐cell lymphotropic virus, HTLV‐I, HTLV‐I serology is a mandatory investigation | Etiologically linked to the human T‐cell lymphotropic virus, HTLV‐I, HTLV‐I serology is a mandatory investigation | ||
Long latency, virus exposure usually occurs very early in life | |||
Transmission of HTLV-1 is believed to occur from mother to child; by sexual contact; and through exposure to contaminated blood, either through blood transfusion or sharing of contaminated needles | Transmission of HTLV-1 is believed to occur from mother to child; by sexual contact; and through exposure to contaminated blood, either through blood transfusion or sharing of contaminated needles | ||
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Diffuse infiltration of the lymph node leading expansion of the paracortical area | Diffuse infiltration of the lymph node leading expansion of the paracortical area | ||
Infiltration of the dermis skin infiltration, epidermotropism present and Pautrier's microabcesses | Infiltration of the dermis skin infiltration, epidermotropism present and Pautrier's microabcesses | ||
antibodies to HTLV‐I are demonstrable | antibodies to HTLV‐I are demonstrable | ||
defects of cell-mediated immunity recurrent infections | |||
+3, +7, +21, monosomy X,deletion of chromosome Y | +3, +7, +21, monosomy X,deletion of chromosome Y and chromosomes 6 and 14q; | ||
14q11 and break points e TCR‐alpha and ‐delta chain genes TCRA and TCRD | 14q11 and break points e TCR‐alpha and ‐delta chain genes TCRA and TCRD | ||
14q32 of TCL1 | 14q32 of TCL1 |
Revision as of 12:56, 3 November 2015
Adult T‐cell leukaemia/lymphoma (ATLL) is a mature T‐cell neoplasm of post‐thymic lymphocytes Etiologically linked to the human T‐cell lymphotropic virus, HTLV‐I, HTLV‐I serology is a mandatory investigation Long latency, virus exposure usually occurs very early in life Transmission of HTLV-1 is believed to occur from mother to child; by sexual contact; and through exposure to contaminated blood, either through blood transfusion or sharing of contaminated needles
The disease manifests in 75% of cases with leukaemia and in the remaining as a pure lymphomatous form
widely disseminated disease which may involve liver, skin, blood stream, bone
anaemia and thrombocytopenia is variable
Neutrophilia and eosinophilia Present
lytic bone lesions
tumor-induced osteolysis hypercalcaemia
elevated serum levels of IL-1, TGFβ, PTHrP, macrophage inflammatory protein (MIP-1α), and receptor activator of nuclear factor-κB ligand (RANKL) have been associated with hypercalcemia
Diffuse infiltration of the lymph node leading expansion of the paracortical area Infiltration of the dermis skin infiltration, epidermotropism present and Pautrier's microabcesses antibodies to HTLV‐I are demonstrable defects of cell-mediated immunity recurrent infections +3, +7, +21, monosomy X,deletion of chromosome Y and chromosomes 6 and 14q; 14q11 and break points e TCR‐alpha and ‐delta chain genes TCRA and TCRD 14q32 of TCL1 mutations of tumour‐suppressor genes CDKN2A (p16), CDKN2B (p15) and TP53 (p53)
pleomorphic, a medium size lymphocyte conndensed chromatin convoluted or polylobated nucleus nucleoli are not visibl cytoplasm agranular “flower cell”
CD4 positive CD8 positive CD2 and CD5 positive CD7 negativ CD3 and T‐cell receptor (TCR)‐β may be down‐regulated