Polycythemia vera laboratory tests: Difference between revisions

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{{Polycythemia vera}}
{{Polycythemia vera}}
==Overview==
==Overview==
Laboratory findings associated with the diagnosis of polycythemia vera include [[erythrocytosis]], [[leukocytosis]], and[[thrombocytosis]].
Laboratory findings associated with the diagnosis of polycythemia vera include [[erythrocytosis]], [[leukocytosis]], and[[thrombocytosis]].<ref name="cancer.ca">Canadian Cancer Society.2015.http://www.cancer.ca/en/cancer-information/cancer-type/leukemia/leukemia/polycythemia-vera/?region=ab</ref>
==Laboratory Findings==
==Laboratory Findings==
Patients with polycythemia vera may often be [[asymptomatic]]. The diagnosis is often suspected on the basis of laboratory tests. Common findings include an elevated hemoglobin level or [[hematocrit]], reflecting the increased number of red blood cells; the [[platelet count]] or [[white blood cell count]] may also be increased. Because polycythemia vera results from an essential increase in erythrocyte production, patients have a low  erythropoietin (EPO) level.
Laboratory findings associated with polycythemia vera include:<ref name="pmid26534968">{{cite journal| author=Hawley JM, Owen LJ, MacKenzie F, Mussell C, Cowen S, Keevil BG| title=Candidate Reference Measurement Procedure for the Quantification of Total Serum Cortisol with LC-MS/MS. | journal=Clin Chem | year= 2015 | volume=  | issue=  | pages=  | pmid=26534968 | doi=10.1373/clinchem.2015.243576 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26534968  }} </ref><ref name="pmid7889510">{{cite journal| author=Amiel A, Gaber E, Manor Y, Fejgin M, Joseph-Lerner N, Ravid M et al.| title=Fluorescence in situ hybridization for the detection of trisomies 8 and 9 in polycythemia vera. | journal=Cancer Genet Cytogenet | year= 1995 | volume= 79 | issue= 2 | pages= 153-6 | pmid=7889510 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7889510  }} </ref><ref name="pmid17178662">{{cite journal| author=Mazzotta S, Guerranti R, Gozzetti A, Bucalossi A, Bocchia M, Sammassimo S et al.| title=Increased serum lactate dehydrogenase isoenzymes in Ph-negative chronic myeloproliferative diseases: a metabolic adaptation? | journal=Hematology | year= 2006 | volume= 11 | issue= 4 | pages= 239-44 | pmid=17178662 | doi=10.1080/10245330600774835 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17178662  }} </ref><ref name="pmid5947579">{{cite journal| author=Denman M, Szur L, Ansell BM| title=Hyperuricaemia in polycythaemia vera. | journal=Ann Rheum Dis | year= 1966 | volume= 25 | issue= 4 | pages= 340-4 | pmid=5947579 | doi= | pmc=PMC2453349 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=5947579  }} </ref><ref name="pmid23606974">{{cite journal| author=Murakami J, Shimizu Y| title=Hepatic manifestations in hematological disorders. | journal=Int J Hepatol | year= 2013 | volume= 2013 | issue=  | pages= 484903 | pmid=23606974 | doi=10.1155/2013/484903 | pmc=PMC3626309 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23606974  }} </ref><ref name="cancer.ca">Canadian Cancer Society.2015.http://www.cancer.ca/en/cancer-information/cancer-type/leukemia/leukemia/polycythemia-vera/?region=ab</ref><ref name="pmid9299851">{{cite journal| author=Remacha AF, Montserrat I, Santamaria A, Oliver A, Barceló MJ, Parellada M| title=Serum erythropoietin in the diagnosis of polycythemia vera. A follow-up study. | journal=Haematologica | year= 1997 | volume= 82 | issue= 4 | pages= 406-10 | pmid=9299851 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9299851  }} </ref>
 
*[[Complete blood count]]
:*Increased [[granulocyte]]s of all types
:*Increased [[basophil]]s and [[eosinophil]]s
:*[[Thrombocytosis]]
:*[[Erythrocytosis]]
:*[[Leukocytosis]]
*Blood chemistry
:*The following blood levels may be elevated:
::*Blood urea nitrogen ([[BUN]])
::*[[Creatinine]]
::*[[Phosphate]]
::*[[Lactate dehydrogenase]] (LDH)
::*[[Alanine aminotransferase]] (ALT)
::*[[Aspartate transaminase]] (AST)
::*[[Uric acid]]
*Bleeding and clotting factor
:*The following blood levels may be elevated:
::*[[Prothrombin time]] (PT) or [[international normalized ratio]] (INR)
::*[[Partial thromboplastin time]] (PTT)
*[[Cytochemistry]]
:*Cytochemistry helps determine the type of cells that are present
*[[Flow cytometry]]
:* Flow cytometry helps determine the type of cells that are present
*[[Cytogenetics]]
*[[Fluorescent in situ hybridization]] (FISH)
*[[Polymerase chain reaction]]
:*Helpful to detect specific abnormalities in blood or bone marrow cells
*[[Erythropoietin]] (EPO)
:* Low in polycythemia vera  
:* High in secondary polycythemia
:* High in relative polycythemia
==References==
==References==
{{Reflist|2}}
{{Reflist|2}}

Revision as of 18:44, 5 November 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2]

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Overview

Laboratory findings associated with the diagnosis of polycythemia vera include erythrocytosis, leukocytosis, andthrombocytosis.[1]

Laboratory Findings

Laboratory findings associated with polycythemia vera include:[2][3][4][5][6][1][7]

  • Blood chemistry
  • The following blood levels may be elevated:
  • Bleeding and clotting factor
  • The following blood levels may be elevated:
  • Cytochemistry helps determine the type of cells that are present
  • Flow cytometry helps determine the type of cells that are present
  • Helpful to detect specific abnormalities in blood or bone marrow cells
  • Low in polycythemia vera
  • High in secondary polycythemia
  • High in relative polycythemia

References

  1. ↑ 1.0 1.1 Canadian Cancer Society.2015.http://www.cancer.ca/en/cancer-information/cancer-type/leukemia/leukemia/polycythemia-vera/?region=ab
  2. ↑ Hawley JM, Owen LJ, MacKenzie F, Mussell C, Cowen S, Keevil BG (2015). "Candidate Reference Measurement Procedure for the Quantification of Total Serum Cortisol with LC-MS/MS". Clin Chem. doi:10.1373/clinchem.2015.243576. PMID 26534968.
  3. ↑ Amiel A, Gaber E, Manor Y, Fejgin M, Joseph-Lerner N, Ravid M; et al. (1995). "Fluorescence in situ hybridization for the detection of trisomies 8 and 9 in polycythemia vera". Cancer Genet Cytogenet. 79 (2): 153–6. PMID 7889510.
  4. ↑ Mazzotta S, Guerranti R, Gozzetti A, Bucalossi A, Bocchia M, Sammassimo S; et al. (2006). "Increased serum lactate dehydrogenase isoenzymes in Ph-negative chronic myeloproliferative diseases: a metabolic adaptation?". Hematology. 11 (4): 239–44. doi:10.1080/10245330600774835. PMID 17178662.
  5. ↑ Denman M, Szur L, Ansell BM (1966). "Hyperuricaemia in polycythaemia vera". Ann Rheum Dis. 25 (4): 340–4. PMC 2453349. PMID 5947579.
  6. ↑ Murakami J, Shimizu Y (2013). "Hepatic manifestations in hematological disorders". Int J Hepatol. 2013: 484903. doi:10.1155/2013/484903. PMC 3626309. PMID 23606974.
  7. ↑ Remacha AF, Montserrat I, Santamaria A, Oliver A, Barceló MJ, Parellada M (1997). "Serum erythropoietin in the diagnosis of polycythemia vera. A follow-up study". Haematologica. 82 (4): 406–10. PMID 9299851.

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