Essential thrombocytosis natural history, complications and prognosis: Difference between revisions
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==Overview== | ==Overview== | ||
If left untreated, patients with Essential thrombocytosis may progress to develop symptoms like headache, dizziness, vision disturbances, chest pain, intense burning pain in hands or feet([[erythromelalgia]]), numbness and tingling of hands and feet, priapism (persistent and painful erection of the penis) and so on depending on the vessel occluded with the thrombi. Complications that can develop as a result of Essential thrombocytosis are thrombotic events (DVT, cerebrovascular accidents,etc), bleeding (bruises, gum bleeds, epistaxis, etc), acute leukemia and myelofibrosis. Essential thrombocytosis is associated with a good prognosis if patients are medically supervised on a regular basis. Lifespan is usually normal as any other unaffected person, though some patients may have symptoms from vascular occlusion and/or bleeding. Rarely the disease may undergo a leukemic conversion or [[myelofibrosis]]. | If left untreated, patients with Essential thrombocytosis may progress to develop symptoms like headache, dizziness, vision disturbances, chest pain, intense burning pain in hands or feet([[erythromelalgia]]), numbness and tingling of hands and feet, [[priapism]] (persistent and painful erection of the penis) and so on depending on the vessel occluded with the thrombi. Complications that can develop as a result of Essential thrombocytosis are thrombotic events ([[DVT]], cerebrovascular accidents,etc), bleeding (bruises, gum bleeds, [[epistaxis]], etc), [[acute leukemia]] and [[myelofibrosis]]. Essential thrombocytosis is associated with a good prognosis if patients are medically supervised on a regular basis. Lifespan is usually normal as any other unaffected person, though some patients may have symptoms from vascular occlusion and/or bleeding. Rarely the disease may undergo a leukemic conversion or [[myelofibrosis]]. | ||
==Natural history== | ==Natural history== | ||
The symptoms of Essential thrombocytosis usually develop in two peaks, one in the third decade of life, and the other in the sixth decade of life. It starts with symptoms including but not limited to headache, dizziness, vision disturbances, chest pain, intense burning pain in hands or feet([[erythromelalgia]]), numbness and tingling of hands and feet and priapism (persistent and painful erection of the penis). Without treatment, patients with very high counts will develop serious complications from vascular occlusions and/or bleeding. Rarely some cases progress to fatal leukemia or [[myelofibrosis]]. | The symptoms of Essential thrombocytosis usually develop in two peaks, one in the third decade of life, and the other in the sixth decade of life. It starts with symptoms including but not limited to headache, dizziness, vision disturbances, chest pain, intense burning pain in hands or feet([[erythromelalgia]]), numbness and tingling of hands and feet and [[priapism]] (persistent and painful erection of the penis). Without treatment, patients with very high counts will develop serious complications from vascular occlusions and/or bleeding. Rarely some cases progress to fatal leukemia or [[myelofibrosis]]. | ||
==Complications== | ==Complications== | ||
*Complications that can develop as a result of Essential thrombocytosis are: | *Complications that can develop as a result of Essential thrombocytosis are: | ||
**Thrombotic events (DVT, cerebrovascular accidents,etc) | **Thrombotic events ([[DVT]], cerebrovascular accidents,etc) | ||
**Bleeding (bruises, gum bleeds, epistaxis, etc) | **Bleeding (bruises, gum bleeds, [[epistaxis]], etc) | ||
**Acute leukemia | **[[Acute leukemia]] | ||
**Myelofibrosis | **[[Myelofibrosis]] | ||
*Bleeding can sometimes worsen with aspirin that is used to relieve symptoms in mild cases of ET. | *Bleeding can sometimes worsen with aspirin that is used to relieve symptoms in mild cases of ET. | ||
Revision as of 18:56, 5 November 2015
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Essential thrombocytosis Microchapters |
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Differentiating Essential thrombocytosis from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
If left untreated, patients with Essential thrombocytosis may progress to develop symptoms like headache, dizziness, vision disturbances, chest pain, intense burning pain in hands or feet(erythromelalgia), numbness and tingling of hands and feet, priapism (persistent and painful erection of the penis) and so on depending on the vessel occluded with the thrombi. Complications that can develop as a result of Essential thrombocytosis are thrombotic events (DVT, cerebrovascular accidents,etc), bleeding (bruises, gum bleeds, epistaxis, etc), acute leukemia and myelofibrosis. Essential thrombocytosis is associated with a good prognosis if patients are medically supervised on a regular basis. Lifespan is usually normal as any other unaffected person, though some patients may have symptoms from vascular occlusion and/or bleeding. Rarely the disease may undergo a leukemic conversion or myelofibrosis.
Natural history
The symptoms of Essential thrombocytosis usually develop in two peaks, one in the third decade of life, and the other in the sixth decade of life. It starts with symptoms including but not limited to headache, dizziness, vision disturbances, chest pain, intense burning pain in hands or feet(erythromelalgia), numbness and tingling of hands and feet and priapism (persistent and painful erection of the penis). Without treatment, patients with very high counts will develop serious complications from vascular occlusions and/or bleeding. Rarely some cases progress to fatal leukemia or myelofibrosis.
Complications
- Complications that can develop as a result of Essential thrombocytosis are:
- Thrombotic events (DVT, cerebrovascular accidents,etc)
- Bleeding (bruises, gum bleeds, epistaxis, etc)
- Acute leukemia
- Myelofibrosis
- Bleeding can sometimes worsen with aspirin that is used to relieve symptoms in mild cases of ET.
Prognosis
- Essential thrombocytosis is associated with a good prognosis if medically supervised on a regular basis.
- Most of the patients remain asymptomatic for most of their life and are diagnosed on routine blood tests. Although some patients with very high counts may present with severe hemorrhagic or thombotic events needing treatment.
- Rarely the disease may progress to acute leukemia or myelofibrosis.