Sandbox: DDx Kidney mass: Difference between revisions

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* 1-2 yo patients
<1 yo patients
* Constitutional symptoms
Large cells with eccentrically located nuclei
* May have abdominal pain, constipation, proptosis, periorbital ecchymoses, back pain, weakness, hypertension, and subcutaneous nodules
Abundant, eosinophilic cytoplasm
* Opsoclonus myoclonus ataxia syndrome
INI1 gene in chromosome 22
 
* Heterogeneous mass on U/S
* Internal vascularity
* Necrosis
* Calcification
 
* Elevated levels of catecholamines, dopamine, homovanillic acid, and vanillylmandelic acid (VMA)
 
* Small round blue cells
* Thin pink fibrous septa
* Homer-Wright rosettes
* Neuropil-like stroma
 
* MYCN oncogene amplification
* PHOX2A gene mutation
* KIF1B gene mutation
* LMO1 gene mutation
 




Revision as of 20:17, 6 November 2015

<1 yo patients Large cells with eccentrically located nuclei Abundant, eosinophilic cytoplasm INI1 gene in chromosome 22



Nonmalignant causes

anaplastic sarcoma clear cell sarcoma mesoblastic nephroma metanephric stromal tumor nephroblastomatosis / nephrogenic rests neuroblastoma oncocytoid carcinoma after neuroblastoma ossifying tumor renal cell carcinoma rhabdoid tumor translocation carcinoma (children) 

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