Waldenström's macroglobulinemia history and symptoms: Difference between revisions
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==Overview== | ==Overview== | ||
==History and Symptoms== | ==History and Symptoms== | ||
Patients with WM may present with various symptoms. | Patients with WM may present with various symptoms.<ref name="pmid23901022">{{cite journal| author=Monge J, Braggio E, Ansell SM| title=Genetic factors and pathogenesis of Waldenström's macroglobulinemia. | journal=Curr Oncol Rep | year= 2013 | volume= 15 | issue= 5 | pages= 450-6 | pmid=23901022 | doi=10.1007/s11912-013-0331-7 | pmc=PMC3807757 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23901022 }} </ref> | ||
*Approximately 30% of the patients are asymptomatic (smoldering WM). | *Approximately 30% of the patients are asymptomatic (smoldering WM). | ||
*Anemia with mean hemoglobin less than 10 g/dL - fatigue | *Anemia with mean hemoglobin less than 10 g/dL - fatigue | ||
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*Extramedullary infiltration - hepatomegaly, splenomegaly, lymphadenopathy | *Extramedullary infiltration - hepatomegaly, splenomegaly, lymphadenopathy | ||
*Hyperviscosity - oronasal bleeding, retinal hemorrhage with blurring or loss of vision, headache, vertigo, ataxia | *Hyperviscosity - oronasal bleeding, retinal hemorrhage with blurring or loss of vision, headache, vertigo, ataxia | ||
*IgM monoclonal proteins - peripheral neuropathy | *IgM monoclonal proteins - peripheral neuropathy | ||
==References== | ==References== | ||
Revision as of 20:50, 6 November 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
History and Symptoms
Patients with WM may present with various symptoms.[1]
- Approximately 30% of the patients are asymptomatic (smoldering WM).
- Anemia with mean hemoglobin less than 10 g/dL - fatigue
- Bone marrow infiltration: cause anemia & pancytopenia
- Extramedullary infiltration - hepatomegaly, splenomegaly, lymphadenopathy
- Hyperviscosity - oronasal bleeding, retinal hemorrhage with blurring or loss of vision, headache, vertigo, ataxia
- IgM monoclonal proteins - peripheral neuropathy
References
- ↑ Monge J, Braggio E, Ansell SM (2013). "Genetic factors and pathogenesis of Waldenström's macroglobulinemia". Curr Oncol Rep. 15 (5): 450–6. doi:10.1007/s11912-013-0331-7. PMC 3807757. PMID 23901022.