Waldenström's macroglobulinemia history and symptoms: Difference between revisions
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==Overview== | ==Overview== | ||
==History and Symptoms== | |||
===Asymptomatic or Smoldering:=== | |||
Presents in 30% of patients with Waldenström's macroglobulinemia.<ref name="HS">Waldenström's macroglobulinemia symptoms and signs. Cancer.Net (2015)http://www.cancer.net/cancer-types/waldenstrom’s-macroglobulinemia/symptoms-and-signs Accessed on November 10, 2015</ref> | |||
===Symptomatic:=== | |||
====Constitutional symptoms==== | |||
:*Weight loss<ref name="HS">Waldenström's macroglobulinemia symptoms and signs. Cancer.Net (2015)http://www.cancer.net/cancer-types/waldenstrom’s-macroglobulinemia/symptoms-and-signs Accessed on November 10, 2015</ref> | |||
:*Fever | |||
:*Night sweat | |||
:*Lymphedema | |||
====Hyperviscosity syndrome==== | |||
Accumulation of IgM proteins in blood can increase the viscosity of blood, slowing down the flow of blood to different organs. Symptoms of hyperviscosity include:<ref name="HS">Waldenström's macroglobulinemia symptoms and signs. Cancer.Net (2015)http://www.cancer.net/cancer-types/waldenstrom’s-macroglobulinemia/symptoms-and-signs Accessed on November 10, 2015</ref> | |||
:*Retinal hemorrhage with blurring of vision problem | |||
:*Vertigo | |||
:*Dizziness | |||
:*Headache | |||
:*Oronasal bleeding | |||
====Bone marrow infiltration==== | |||
::*Anemia<ref name="pmid23901022">{{cite journal| author=Monge J, Braggio E, Ansell SM| title=Genetic factors and pathogenesis of Waldenström's macroglobulinemia. | journal=Curr Oncol Rep | year= 2013 | volume= 15 | issue= 5 | pages= 450-6 | pmid=23901022 | doi=10.1007/s11912-013-0331-7 | pmc=PMC3807757 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23901022 }} </ref> | |||
::*Pancytopenia | |||
References: | |||
{{Reflist|2}} | |||
==History and Symptoms== | ==History and Symptoms== | ||
Patients with WM may present with various symptoms.<ref name="pmid23901022">{{cite journal| author=Monge J, Braggio E, Ansell SM| title=Genetic factors and pathogenesis of Waldenström's macroglobulinemia. | journal=Curr Oncol Rep | year= 2013 | volume= 15 | issue= 5 | pages= 450-6 | pmid=23901022 | doi=10.1007/s11912-013-0331-7 | pmc=PMC3807757 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23901022 }} </ref> | Patients with WM may present with various symptoms.<ref name="pmid23901022">{{cite journal| author=Monge J, Braggio E, Ansell SM| title=Genetic factors and pathogenesis of Waldenström's macroglobulinemia. | journal=Curr Oncol Rep | year= 2013 | volume= 15 | issue= 5 | pages= 450-6 | pmid=23901022 | doi=10.1007/s11912-013-0331-7 | pmc=PMC3807757 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23901022 }} </ref> | ||
Revision as of 14:26, 10 November 2015
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Waldenström's macroglobulinemia Microchapters |
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Differentiating Waldenström's macroglobulinemia from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Waldenström's macroglobulinemia history and symptoms On the Web |
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American Roentgen Ray Society Images of Waldenström's macroglobulinemia history and symptoms |
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Waldenström's macroglobulinemia history and symptoms in the news |
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Blogs on Waldenström's macroglobulinemia history and symptoms |
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Directions to Hospitals Treating Waldenström's macroglobulinemia |
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Risk calculators and risk factors for Waldenström's macroglobulinemia history and symptoms |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
|
Waldenström's macroglobulinemia Microchapters |
|
Differentiating Waldenström's macroglobulinemia from other Diseases |
|---|
|
Diagnosis |
|
Treatment |
|
Case Studies |
|
Waldenström's macroglobulinemia history and symptoms On the Web |
|
American Roentgen Ray Society Images of Waldenström's macroglobulinemia history and symptoms |
|
Waldenström's macroglobulinemia history and symptoms in the news |
|
Blogs on Waldenström's macroglobulinemia history and symptoms |
|
Directions to Hospitals Treating Waldenström's macroglobulinemia |
|
Risk calculators and risk factors for Waldenström's macroglobulinemia history and symptoms |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2]
Overview
History and Symptoms
Asymptomatic or Smoldering:
Presents in 30% of patients with Waldenström's macroglobulinemia.[1]
Symptomatic:
Constitutional symptoms
- Weight loss[1]
- Fever
- Night sweat
- Lymphedema
Hyperviscosity syndrome
Accumulation of IgM proteins in blood can increase the viscosity of blood, slowing down the flow of blood to different organs. Symptoms of hyperviscosity include:[1]
- Retinal hemorrhage with blurring of vision problem
- Vertigo
- Dizziness
- Headache
- Oronasal bleeding
Bone marrow infiltration
- Anemia[2]
- Pancytopenia
References:
- ↑ 1.0 1.1 1.2 Waldenström's macroglobulinemia symptoms and signs. Cancer.Net (2015)http://www.cancer.net/cancer-types/waldenstrom’s-macroglobulinemia/symptoms-and-signs Accessed on November 10, 2015
- ↑ Monge J, Braggio E, Ansell SM (2013). "Genetic factors and pathogenesis of Waldenström's macroglobulinemia". Curr Oncol Rep. 15 (5): 450–6. doi:10.1007/s11912-013-0331-7. PMC 3807757. PMID 23901022.
History and Symptoms
Patients with WM may present with various symptoms.[1]
- Approximately 30% of the patients are asymptomatic (smoldering WM).
- Anemia with mean hemoglobin less than 10 g/dL - fatigue
- Bone marrow infiltration: cause anemia & pancytopenia
- Extramedullary infiltration - hepatomegaly, splenomegaly, lymphadenopathy
- Hyperviscosity - oronasal bleeding, retinal hemorrhage with blurring or loss of vision, headache, vertigo, ataxia
- IgM monoclonal proteins - peripheral neuropathy
References
- ↑ Monge J, Braggio E, Ansell SM (2013). "Genetic factors and pathogenesis of Waldenström's macroglobulinemia". Curr Oncol Rep. 15 (5): 450–6. doi:10.1007/s11912-013-0331-7. PMC 3807757. PMID 23901022.